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PMID: 15133664 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Organization of Iroquois genes in fish.

Development genes and evolution ·Vol. 214 ·No. 6 ·2004-06-00 ·Pages 267-76

Dildrop R, Rüther U

Abstract

In mammals, a total of six iroquois ( Irx) genes exist, which are organized into two clusters. Here we report on the organization of all iroquois genes present in fish, using zebrafish ( Danio rerio) and pufferfish ( Fugu rubripes and Tetraodon nigroviridis) as examples. A total of 10 Irx genes were found in pufferfish, and 11 in zebrafish; all but one of these genes are organized into clusters (four clusters plus one isolated gene locus). The "extra" fish clusters result from chromosome duplication in the fish lineage, after its divergence from tetrapod vertebrates. Two of the four fish clusters are highly conserved to the ones in mammals, with regard to similarity of genes and cluster architecture. Irx genes within the other two clusters have diverged in sequence and cluster organization, suggesting functional divergence. These results will allow us to use the zebrafish system for functional and comparative studies of iroquois genes in vertebrate development.

MeSH Terms
Animals Evolution, Molecular Gene Duplication Gene Expression Genetic Linkage Genome Homeodomain Proteins/genetics Multigene Family Phylogeny Takifugu/genetics Transcription Factors/genetics Zebrafish/genetics Zebrafish Proteins
Chemicals
Homeodomain Proteins Transcription Factors Zebrafish Proteins irx1a protein, zebrafish
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dildrop Renate
Institute for Animal Developmental and Molecular Biology, University of Düsseldorf, Universitätsstrasse 1, 40225, Düsseldorf, Germany.
Rüther Ulrich
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Article Info
Journal
Development genes and evolution
Abbr.
Dev Genes Evol
ISSN
0949-944X
DOI
10.1007/s00427-004-0402-8
Published
2004-06-00
Epub
2004-00-06
Pages
267-76
Language
English
Region
Germany
NLM ID
9613264
Subset
IM
External Links
PubMed source DOI: 10.1007/s00427-004-0402-8 View journal details
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