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PMID: 9427752 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate.

The EMBO journal ·Vol. 17 ·No. 1 ·1998-01-02 ·Pages 181-90

Gómez-Skarmeta JL, Glavic A, de la Calle-Mustienes E, Modolell J, Mayor R

Abstract

The Drosophila homeoproteins Ara and Caup are members of a combination of factors (prepattern) that control the highly localized expression of the proneural genes achaete and scute. We have identified two Xenopus homologs of ara and caup, Xiro1 and Xiro2. Similarly to their Drosophila counterparts, they control the expression of proneural genes and, probably as a consequence, the size of the neural plate. Moreover, Xiro1 and Xiro2 are themselves controlled by noggin and retinoic acid and, similarly to ara and caup, they are overexpressed by expression in Xenopus embryos of the Drosophila cubitus interruptus gene. These and other findings suggest the conservation of at least part of the genetic cascade that regulates proneural genes, and the existence in vertebrates of a prepattern of factors important to control the differentiation of the neural plate.

MeSH Terms
Amino Acid Sequence Animals Cloning, Molecular Drosophila/genetics Drosophila Proteins Ectoderm/metabolism Gene Expression Regulation, Developmental Homeodomain Proteins/genetics Molecular Sequence Data Nerve Tissue Proteins Nervous System/embryology Sequence Homology, Amino Acid Transcription Factors/genetics Xenopus/embryology,genetics Xenopus Proteins
Chemicals
ARA protein, Drosophila Drosophila Proteins Homeodomain Proteins IRX2 protein, Xenopus Nerve Tissue Proteins Transcription Factors Xenopus Proteins Xiro1 protein, Xenopus caup protein, Drosophila
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Gómez-Skarmeta J L
Laboratorio de Biología del Desarrollo, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile.
Glavic A
de la Calle-Mustienes E
Modolell J
Mayor R
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
DOI
10.1093/emboj/17.1.181
Published
1998-01-02
Pages
181-90
Language
English
Region
England
NLM ID
8208664
PMCID
PMC1170369
Subset
IM
Databases
GENBANK
AJ001834, AJ001835
External Links
PubMed source DOI: 10.1093/emboj/17.1.181 PMC Full Text View journal details
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