The Wnt-activated Xiro1 gene encodes a repressor that is essential for neural development and downregulates Bmp4.

Animals Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins/antagonists & inhibitors,genetics,metabolism Cell Differentiation Cell Lineage DNA/genetics,metabolism DNA-Binding Proteins/antagonists & inhibitors,genetics,metabolism Down-Regulation Ectoderm/metabolism Embryo, Nonmammalian/embryology,metabolism Gastrula/metabolism Gene Expression Regulation, Developmental HMGB Proteins Histocytochemistry Homeodomain Proteins/genetics,metabolism In Situ Hybridization Mesoderm/metabolism Nerve Tissue Proteins/genetics Nervous System/embryology,metabolism Neuropilin-1 Nuclear Proteins/genetics Promoter Regions, Genetic/genetics Proto-Oncogene Proteins/metabolism RNA, Messenger/genetics,metabolism Repressor Proteins/genetics,metabolism SOXB1 Transcription Factors Signal Transduction Transcription Factors/antagonists & inhibitors,genetics,metabolism Wnt Proteins Xenopus/embryology,genetics Xenopus Proteins Zebrafish Proteins

Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins DNA-Binding Proteins HMGB Proteins Homeodomain Proteins IRX2 protein, Xenopus Nerve Tissue Proteins Nuclear Proteins Proto-Oncogene Proteins RNA, Messenger Repressor Proteins SOXB1 Transcription Factors Transcription Factors Wnt Proteins Xenopus Proteins Xiro1 protein, Xenopus Zebrafish Proteins bmp4 protein, Xenopus bmp4 protein, zebrafish sox2 protein, Xenopus Neuropilin-1 DNA