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PMID: 14977182 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Interplay between mitochondria and cellular calcium signalling.

Molecular and cellular biochemistry ·Vol. 256-257 ·No. 1-2 ·2004-00-00 ·Pages 209-18

Jacobson J, Duchen MR

Abstract

Mitochondria are increasingly ascribed central roles in vital cell signalling cascades. These organelles are now recognised as initiators and transducers of a range of cell signals, including those central to activation and amplification of apoptotic cell death. Moreover, as the main source of cellular ATP, mitochondria must be responsive to fluctuating energy demands of the cell. As local and global fluctuations in calcium concentration are ubiquitous in eukaryotic cells and are the common factor in a dizzying array of intra- and inter-cellular signalling cascades, the relationships between mitochondrial function and calcium transients is currently a subject of intense scrutiny. It is clear that mitochondria not only act as local calcium buffers, thus shaping spatiotemporal aspects of cytosolic calcium signals, but that they also respond to calcium uptake by upregulating the tricarboxylic acid cycle, thus reacting metabolically to local signalling. In this chapter we review current knowledge of mechanisms of mitochondrial calcium uptake and release and discuss the consequences of mitochondrial calcium handling for cell function, particularly in conjunction with mitochondrial oxidative stress.

MeSH Terms
Calcium Signaling Mitochondria/metabolism Oxidative Stress
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jacobson Jake
Department of Physiology, University College London, London, UK. j.jacobson@ucl.ac.uk
Duchen Michael R
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Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
DOI
10.1023/b:mcbi.0000009869.29827.df
Email
j.jacobson@ucl.ac.uk
Published
2004-00-00
Pages
209-18
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
External Links
PubMed source DOI: 10.1023/b:mcbi.0000009869.29827.df View journal details
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