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PMID: 14740316 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Evidence of a novel quantitative-trait locus for obesity on chromosome 4p in Mexican Americans.

American journal of human genetics ·Vol. 74 ·No. 2 ·2004-02-00 ·Pages 272-82

Arya R, Duggirala R, Jenkinson CP, Almasy L, Blangero J, O'Connell P, Stern MP

Abstract

Although several genomewide scans have identified quantitative-trait loci influencing several obesity-related traits in humans, genes influencing normal variation in obesity phenotypes have not yet been identified. We therefore performed a genome scan of body mass index (BMI) on Mexican Americans, a population prone to obesity and diabetes, using a variance-components linkage analysis to identify loci that influence BMI. We used phenotypic data from 430 individuals (26% diabetics, 59% females, mean age +/- SD = 43 +/- 17 years, mean BMI +/- SD = 30.0 +/- 6.7, mean leptin (ng/ml) +/- SD = 22.1 +/- 17.1) distributed across 27 low-income Mexican American pedigrees who participated in the San Antonio Family Diabetes Study (SAFDS) for whom a 10-15-cM map is available. In this genomewide search, after accounting for the covariate effects of age, sex, diabetes, and leptin, we identified a genetic region exhibiting the most highly significant evidence for linkage (LOD 4.5) with BMI on chromosome 4p (4p15.1) at 42 cM, near marker D4S2912. This linkage result has been confirmed in an independent linkage study of severe obesity in Utah pedigrees. Two strong positional candidates, the human peroxisome proliferator-activated receptor gamma coactivator 1 (PPARGC1) and cholecystokinin A receptor (CCKAR) with major roles in the development of obesity, are located in this region. In conclusion, we identified a major genetic locus influencing BMI on chromosome 4p in Mexican Americans.

MeSH Terms
Body Mass Index Chromosomes, Human, Pair 4 Humans Lod Score Mexican Americans/genetics Obesity/genetics Phenotype Quantitative Trait Loci
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Arya Rector
Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA. arya@uthscsa.edu
Duggirala Ravindranath
Jenkinson Christopher P
Almasy Laura
Blangero John
O'Connell Peter
Stern Michael P
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
DOI
10.1086/381717
Email
arya@uthscsa.edu
Published
2004-02-00
Epub
2004-00-20
Pages
272-82
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1181925
Subset
IM
Grants
NIDDK NIH HHS · R01 DK047482 · United States
NIDDK NIH HHS · R01 DK079195 · United States
NIMH NIH HHS · MH59490 · United States
NIDDK NIH HHS · DK53889 · United States
NIMH NIH HHS · R01 MH059490 · United States
NIMH NIH HHS · R37 MH059490 · United States
NIDDK NIH HHS · DK42273 · United States
NIDDK NIH HHS · DK47482 · United States
NIDDK NIH HHS · R01 DK053889 · United States
Corrections
ErratumIn
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External Links
PubMed source DOI: 10.1086/381717 PMC Full Text View journal details
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