Chromosomal localization of the gastric and brain receptors for cholecystokinin (CCKAR and CCKBR) in human and mouse.

Genomics ·Vol. 25 ·No. 3 ·1995-02-10 ·Pages 727-9

Huppi K, Siwarski D, Pisegna JR, Wank S

Abstract

Receptors for cholcystokinin (CCK) can be pharmacologically classified into at least two distinct subtypes, CCKAR and CCKBR. In an effort to determine whether the CCKA and CCKB receptors may be associated with certain CNS or gastrointestinal diseases, we have localized and compared the human and mouse chromosomal loci encoded by the CCKAR and CCKBR genes. The gene encoding the CCKA receptor maps to a syntenic region of human chromosome 4 and mouse chromosome 5. The CCKB receptor gene, on the other hand, resides on a syntenic region of human chromosome 11 and distal mouse chromosome 7. Localization of the CCK receptors with two dopamine receptors, DRD5 (4p15.1-p15.3) and DRD4 (11p15), provides the interesting possibility of coinvolvement in neuropsychiatric or CNS illnesses.

MeSH Terms

Animals Base Sequence Brain Chemistry Chromosome Mapping Chromosomes, Human, Pair 4 Cricetinae DNA Primers Humans Hybrid Cells Mice Mice, Inbred BALB C Molecular Sequence Data Polymerase Chain Reaction Receptor, Cholecystokinin A Receptor, Cholecystokinin B Receptors, Cholecystokinin/genetics Receptors, Dopamine/genetics Stomach/chemistry

Chemicals

DNA Primers Receptor, Cholecystokinin A Receptor, Cholecystokinin B Receptors, Cholecystokinin Receptors, Dopamine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Huppi K

Molecular Genetics Section, Laboratory of Genetics, NCI/NIH, Bethesda, Maryland 20892, USA.

Siwarski D

Pisegna J R

Wank S

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Article Info

Journal

Genomics

Abbr.

Genomics

ISSN

0888-7543

DOI

10.1016/0888-7543(95)80018-h

Published

1995-02-10

Pages

727-9

Language

English

Region

United States

NLM ID

8800135

PMCID

PMC6736545

Subset

Grants

RRD VA · I01 RX000194 · United States

NIDDK NIH HHS · P30 DK041301 · United States

External Links

PubMed source DOI: 10.1016/0888-7543(95)80018-h PMC Full Text View journal details

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Chromosomal localization of the gastric and brain receptors for cholecystokinin (CCKAR and CCKBR) in human and mouse.

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