Adaptive thermogenesis: turning on the heat.

Current biology : CB ·Vol. 8 ·No. 15 ·1998-07-16 ·Pages R517-20

Lowell BB

Abstract

Brown adipocytes play important roles in the regulation of fat storage and body temperature, by virtue of their ability to uncouple mitochondrial fuel oxidation and ATP synthesis. The discovery of a tissue-specific transcriptional coactivator provides new insights into the regulation of thermogenesis by brown adipocytes.

MeSH Terms

Adaptation, Physiological/physiology Adipocytes Adipose Tissue, Brown/cytology,physiology Animals Body Temperature Regulation/physiology Carrier Proteins/genetics Cyclic AMP/metabolism Ion Channels Membrane Proteins/genetics Mitochondrial Proteins Receptors, Cytoplasmic and Nuclear/metabolism Transcription Factors/genetics,metabolism,physiology Uncoupling Agents Uncoupling Protein 1

Chemicals

Carrier Proteins Ion Channels Membrane Proteins Mitochondrial Proteins Receptors, Cytoplasmic and Nuclear Transcription Factors Uncoupling Agents Uncoupling Protein 1 peroxisome-proliferator-activated receptor-gamma coactivator-1 Cyclic AMP

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Lowell B B

Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. blowell@bidmc.harvard.edu

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(07)00336-3

blowell@bidmc.harvard.edu

Published

1998-07-16

Pages

R517-20

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(07)00336-3 View journal details

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