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PMID: 7584987 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects.

Nature medicine ·Vol. 1 ·No. 11 ·1995-11-00 ·Pages 1155-61

Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S

Abstract

Leptin, the gene product of the obese gene, may play an important role in regulating body weight by signalling the size of the adipose tissue mass. Plasma leptin was found to be highly correlated with body mass index (BMI) in rodents and in 87 lean and obese humans. In humans, there was variability in plasma leptin at each BMI suggesting that there are differences in its secretion rate from fat. Weight loss due to food restriction was associated with a decrease in plasma leptin in samples from mice and obese humans.

MeSH Terms
Adult Animals Body Mass Index Energy Intake Fasting Female Humans Immunoblotting Indians, North American Leptin Male Mice Mice, Inbred Strains Mice, Obese Middle Aged Obesity/blood,ethnology Proteins/analysis,genetics RNA/genetics,metabolism Rats Rats, Mutant Strains Weight Loss Whites
Chemicals
Leptin Proteins RNA
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Maffei M
Laboratory of Molecular Genetics, Rockefeller University, New York, New York 10021, USA.
Halaas J
Ravussin E
Pratley R E
Lee G H
Zhang Y
Fei H
Kim S
Lallone R
Ranganathan S
Article Info
Journal
Nature medicine
Abbr.
Nat Med
ISSN
1078-8956
DOI
10.1038/nm1195-1155
Published
1995-11-00
Pages
1155-61
Language
English
Region
United States
NLM ID
9502015
Subset
IM
Grants
NIDDK NIH HHS · DK39176 · United States
NIDDK NIH HHS · DK41096 · United States
NCRR NIH HHS · RR00862 · United States
External Links
PubMed source DOI: 10.1038/nm1195-1155 View journal details
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