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PMID: 14662358 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

RNA asymmetric distribution and daughter/mother differentiation in yeast.

Current opinion in microbiology ·Vol. 6 ·No. 6 ·2003-12-00 ·Pages 614-20

Darzacq X, Powrie E, Gu W, Singer RH, Zenklusen D

Abstract

Active transport and localized translation of the ASH1 mRNA at the bud tip of the budding yeast Saccharomyces cerevisiae is an essential process that is required for the regulation of the mating type switching. ASH1 mRNA localization has been extensively studied over the past few years and the core components of the translocation machinery have been identified. It is composed of four localization elements (zipcodes), within the ASH1 mRNA, and at least three proteins, She1p/Myo4p, She2p and She3p. Whereas the movement of the RNA can be attributed to direct interaction with myosin, the regulation of the RNA expression is less well understood. Recent insights have revealed a role for translation that might have a key function in the regulation of Ash1 protein sorting.

MeSH Terms
Biological Transport RNA, Fungal/metabolism Saccharomyces cerevisiae/genetics,growth & development
Chemicals
RNA, Fungal
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Darzacq Xavier
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Powrie Erin
Gu Wei
Singer Robert H
Zenklusen Daniel
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Article Info
Journal
Current opinion in microbiology
Abbr.
Curr Opin Microbiol
ISSN
1369-5274
DOI
10.1016/j.mib.2003.10.005
Published
2003-12-00
Pages
614-20
Language
English
Region
England
NLM ID
9815056
PMCID
PMC4956921
Subset
IM
Grants
NIGMS NIH HHS · R01 GM057071 · United States
NIGMS NIH HHS · GM 57071 · United States
External Links
PubMed source DOI: 10.1016/j.mib.2003.10.005 PMC Full Text View journal details
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