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PMID: 13295488 Published · ppublish English Journal Article

The purification of hypertensin II.

The Journal of experimental medicine ·Vol. 103 ·No. 3 ·1956-03-01 ·Pages 301-7

SKEGGS LT, KAHN JR, SHUMWAY NP

Abstract

The enzymatic conversion of hypertensin I to hypertensin II is described together with the subsequent purification of the product by means of counter-current distribution. Improved methods are also presented for the preparation of renin and its substrate, as well as in methods for the reaction of these materials and the purification of the resulting hypertensin I.

Keywords
ANGIOTONIN/preparation of
MeSH Terms
Angiotensin Amide Angiotensins
Chemicals
Angiotensins Angiotensin Amide
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
SKEGGS L T
KAHN J R
SHUMWAY N P
References (10)
10 references, click to expand
  1. Countercurrent distribution.
    Methods Med Res. 1952;5:3-24 PMID: 13002089
  2. A method of assaying small amounts of hypertensin.
    Lab Invest. 1953 Mar-Apr;2(2):109-14 PMID: 13045413
  3. The existence of two forms of hypertensin.
    J Exp Med. 1954 Mar;99(3):275-82 PMID: 13130799
  4. The purification of hypertensin I.
    J Exp Med. 1954 Oct 1;100(4):363-70 PMID: 13201713
  5. Amino acid composition and electrophoretic properties of hypertensin I.
    J Exp Med. 1955 Oct 1;102(4):435-40 PMID: 13263485
  6. The preparation and function of the hypertensin-converting enzyme.
    J Exp Med. 1956 Mar 1;103(3):295-9 PMID: 13295487
  7. The isolation and assay of hypertensin from blood.
    J Exp Med. 1952 Mar;95(3):241-6 PMID: 14927788
  8. The assay of hypertensin from the arterial blood of normotensive and hypertensive human beings.
    J Exp Med. 1952 Jun;95(6):523-9 PMID: 14946317
  9. THE RENAL HUMORAL PRESSOR MECHANISM IN MAN. I. PREPARATION AND ASSAY OF HUMAN RENIN, HUMAN HYPERTENSINOGEN, AND HYPERTENSIN.
    J Clin Invest. 1945 Jan;24(1):62-8 PMID: 16695189
  10. STUDIES ON EXPERIMENTAL HYPERTENSION : XXI. THE PURIFICATION OF RENIN.
    J Exp Med. 1943 Jul 1;78(1):67-74 PMID: 19871310
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.103.3.301
Published
1956-03-01
Pages
301-7
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2136592
Subset
OM
External Links
PubMed source DOI: 10.1084/jem.103.3.301 PMC Full Text View journal details
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