The existence of two forms of hypertensin.
Two types of hypertensin have been demonstrated by means of counter-current distribution. The first type is the product of the action of the enzyme, renin, upon its substrate and has been designated hypertensin I. It can be rapidly converted to a second approximately equally pressor compound, hypertensin II, apparently through the action of an enzyme in the plasma which requires halide or nitrate for activation. A highly purified preparation containing horse hypertensins I and II caused an elevation of blood pressure when injected into human beings.
8 references, click to expand
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STUDIES ON EXPERIMENTAL HYPERTENSION : XXI. THE PURIFICATION OF RENIN.J Exp Med. 1943 Jul 1;78(1):67-74 PMID: 19871310
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The isolation and assay of hypertensin from blood.J Exp Med. 1952 Mar;95(3):241-6 PMID: 14927788
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The isolation of hypertensin from the circulating blood of dogs by dialysis in an artificial kidney.Circulation. 1950 Sep;2(3):363-8 PMID: 15434937
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Artificial kidney; construction and operation of an improved continuous dialyzer.Proc Soc Exp Biol Med. 1949 Dec;72(3):539-43 PMID: 15400789
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The assay of hypertensin from the arterial blood of normotensive and hypertensive human beings.J Exp Med. 1952 Jun;95(6):523-9 PMID: 14946317
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A method of assaying small amounts of hypertensin.Lab Invest. 1953 Mar-Apr;2(2):109-14 PMID: 13045413
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The isolation of hypertensin from the circulating blood of normal dogs with experimental renal hypertension by dialysis in an artificial kidney.Circulation. 1951 Mar;3(3):384-9 PMID: 14812667
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THE RENAL HUMORAL PRESSOR MECHANISM IN MAN. I. PREPARATION AND ASSAY OF HUMAN RENIN, HUMAN HYPERTENSINOGEN, AND HYPERTENSIN.J Clin Invest. 1945 Jan;24(1):62-8 PMID: 16695189
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