The purification of hypertensin I.
The purification of hypertensin I has been described. The final product which is four times as powerful a pressor agent as l-arterenol, is obtained with an over-all recovery of 40 per cent. The product consists of a single component in countercurrent distribution, having a nitrogen content of 15.97 per cent and a specific activity of 7050 Goldblatt units per mg. of N or 1125 units per mg. of solid. Acid hydrolysis and paper chromatography indicate in a preliminary fashion that there are about nine amino acids present in the intact polypeptide.
9 references, click to expand
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Countercurrent distribution.Methods Med Res. 1952;5:3-24 PMID: 13002089
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A method of assaying small amounts of hypertensin.Lab Invest. 1953 Mar-Apr;2(2):109-14 PMID: 13045413
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The existence of two forms of hypertensin.J Exp Med. 1954 Mar;99(3):275-82 PMID: 13130799
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The extraction and purification of hypertension (angiotonin).J Biol Chem. 1954 Feb;206(2):717-24 PMID: 13143033
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The isolation of hypertensin from the circulating blood of normal dogs with experimental renal hypertension by dialysis in an artificial kidney.Circulation. 1951 Mar;3(3):384-9 PMID: 14812667
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The isolation and assay of hypertensin from blood.J Exp Med. 1952 Mar;95(3):241-6 PMID: 14927788
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The assay of hypertensin from the arterial blood of normotensive and hypertensive human beings.J Exp Med. 1952 Jun;95(6):523-9 PMID: 14946317
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Artificial kidney; construction and operation of an improved continuous dialyzer.Proc Soc Exp Biol Med. 1949 Dec;72(3):539-43 PMID: 15400789
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THE RENAL HUMORAL PRESSOR MECHANISM IN MAN. I. PREPARATION AND ASSAY OF HUMAN RENIN, HUMAN HYPERTENSINOGEN, AND HYPERTENSIN.J Clin Invest. 1945 Jan;24(1):62-8 PMID: 16695189
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