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PMID: 12794191 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Virus entry, assembly, budding, and membrane rafts.

Microbiology and molecular biology reviews : MMBR ·Vol. 67 ·No. 2 ·2003-06-00 ·Pages 226-37, table of contents

Chazal N, Gerlier D

Abstract

As intracellular parasites, viruses rely heavily on the use of numerous cellular machineries for completion of their replication cycle. The recent discovery of the heterogeneous distribution of the various lipids within cell membranes has led to the proposal that sphingolipids and cholesterol tend to segregate in microdomains called membrane rafts. The involvement of membrane rafts in biosynthetic traffic, signal transduction, and endocytosis has suggested that viruses may also take advantage of rafts for completion of some steps of their replication cycle, such as entry into their cell host, assembly, and budding. In this review, we have attempted to delineate all the reliable data sustaining this hypothesis and to build some models of how rafts are used as platforms for assembly of some viruses. Indeed, if in many cases a formal proof of raft involvement in a virus replication cycle is still lacking, one can reasonably suggest that, owing to their ability to specifically attract some proteins, lipid microdomains provide a particular milieu suitable for increasing the efficiency of many protein-protein interactions which are crucial for virus infection and growth.

MeSH Terms
Animals Cell Membrane/metabolism,virology Humans Membrane Lipids/metabolism Membrane Microdomains/metabolism,virology Virus Assembly/physiology Virus Physiological Phenomena Virus Replication/physiology
Chemicals
Membrane Lipids
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chazal Nathalie
Immunologie-Virologie, EA 3038, Université Paul Sabatier, 31062 Toulouse, France. chazal@cict.fr
Gerlier Denis
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Article Info
Journal
Microbiology and molecular biology reviews : MMBR
Abbr.
Microbiol Mol Biol Rev
ISSN
1092-2172
DOI
10.1128/MMBR.67.2.226-237.2003
Email
chazal@cict.fr
Published
2003-06-00
Pages
226-37, table of contents
Language
English
Region
United States
NLM ID
9706653
PMCID
PMC156468
Subset
IM
External Links
PubMed source DOI: 10.1128/MMBR.67.2.226-237.2003 PMC Full Text View journal details
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