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PMID: 12642608 Published · ppublish English Journal Article Review

Polarized growth and organelle segregation in yeast: the tracks, motors, and receptors.

The Journal of cell biology ·Vol. 160 ·No. 6 ·2003-03-17 ·Pages 811-6

Bretscher A

Abstract

In yeast, growth and organelle segregation requires formin-dependent assembly of polarized actin cables. These tracks are used by myosin Vs to deliver secretory vesicles for cell growth, organelles for their segregation, and mRNA for fate determination. Several specific receptors have been identified that interact with the cargo-binding tails of the myosin Vs. A recent study implicates specific degradation in the bud of the vacuolar receptor, Vac17, as a mechanism for cell cycle-regulated segregation of this organelle.

MeSH Terms
Actin Cytoskeleton/metabolism,ultrastructure Cell Cycle/physiology Molecular Motor Proteins/metabolism Myosin Type V/metabolism Organelles/metabolism,ultrastructure Protein Transport/physiology Receptors, Cell Surface/metabolism Saccharomyces cerevisiae Proteins/metabolism Vacuoles/metabolism,ultrastructure Vesicular Transport Proteins Yeasts/metabolism,ultrastructure
Chemicals
Molecular Motor Proteins Receptors, Cell Surface Saccharomyces cerevisiae Proteins VAC17 protein, S cerevisiae Vesicular Transport Proteins Myosin Type V
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Bretscher Anthony
Dept. of Molecular Biology and Genetics, Biotechnology Bldg., Cornell University, Ithaca, NY 14853, USA. apb5@cornell.edu
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.200301035
Email
apb5@cornell.edu
Published
2003-03-17
Pages
811-6
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2173777
Subset
IM
External Links
PubMed source DOI: 10.1083/jcb.200301035 PMC Full Text View journal details
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