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PMID: 11517381 Published · ppublish English Comparative Study Journal Article Review

HIV in the CNS: pathogenic relationships to systemic HIV disease and other CNS diseases.

Journal of neurovirology ·Vol. 7 ·No. 2 ·2001-04-00 ·Pages 85-96

Rausch DM, Davis MR

Abstract

Research on the pathogenesis of the human immunodeficiency virus (HIV) infection of the central nervous system (CNS) has reached a pivotal stage. While the incidence of HIV dementia appears to be declining, the prevalence of milder, yet debilitating, neuropsychological impairments may rise as individuals infected with HIV live longer. There are also concerns about CNS reservoirs of latently infected cells. Building upon progress in understanding HIV neuropathogenesis, the time is ideal to expand research on the interrelationships between the CNS and systemic HIV disease, and extend the boundaries of this research to the neuropathogenic similarities between HIV and other CNS inflammatory diseases. Neuropathogenic insights gained from these pursuits can spawn new treatment strategies for HIV/CNS disease as well as potentially other diseases of the nervous system.

MeSH Terms
AIDS Dementia Complex/immunology,pathology,physiopathology Alzheimer Disease/immunology,pathology,physiopathology Humans Multiple Sclerosis/immunology,pathology,physiopathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rausch D M
National Institute of Mental Health, Center for Mental Health Research on AIDS, Bethesda, Maryland 20892-9623, USA. dr89b@nih.gov
Davis M R
References (146)
146 references, click to expand
  1. Monokine products as predictors of AIDS dementia.
    AIDS. 1996 Nov;10(13):1495-500 PMID: 8931783
  2. Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis.
    Am J Pathol. 1996 Nov;149(5):1459-67 PMID: 8909235
  3. The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex.
    Science. 1988 Feb 5;239(4840):586-92 PMID: 3277272
  4. Early viral brain invasion in iatrogenic human immunodeficiency virus infection.
    Neurology. 1992 Sep;42(9):1736-9 PMID: 1513462
  5. Distribution of brain HIV load in AIDS.
    Brain Pathol. 1998 Apr;8(2):277-84 PMID: 9546286
  6. Bone marrow derived elements and resident microglia in brain inflammation.
    Glia. 1993 Jan;7(1):19-24 PMID: 7678581
  7. Insights into the neurodegenerative process of Alzheimer's disease: a role for mononuclear phagocyte-associated inflammation and neurotoxicity.
    J Leukoc Biol. 1999 Apr;65(4):416-27 PMID: 10204569
  8. Early SIV encephalopathy.
    J Med Primatol. 1991 Jun;20(4):159-66 PMID: 1942006
  9. Current approaches to treatment for HIV-1 infection.
    J Neurovirol. 2000 May;6 Suppl 1:S8-S13 PMID: 10871760
  10. Cortical synaptic density is reduced in mild to moderate human immunodeficiency virus neurocognitive disorder. HNRC Group. HIV Neurobehavioral Research Center.
    Brain Pathol. 1999 Apr;9(2):209-17 PMID: 10219738
  11. Possible different mechanism between amyloid-beta (25-35)-and substance P-induced chemotaxis of murine microglia.
    Gerontology. 1997;43 Suppl 1:11-5 PMID: 9187934
  12. Neuronal injury associated with HIV-1: approaches to treatment.
    Annu Rev Pharmacol Toxicol. 1998;38:159-77 PMID: 9597152
  13. Beta-chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia.
    Ann Neurol. 1998 Nov;44(5):831-5 PMID: 9818943
  14. HIV mediates a productive infection of the brain.
    AIDS. 1999 Oct 22;13(15):2055-9 PMID: 10546857
  15. Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia.
    Ann Neurol. 1993 Jun;33(6):576-82 PMID: 8498837
  16. Blood-brain barrier abnormalities in the acquired immunodeficiency syndrome: immunohistochemical localization of serum proteins in postmortem brain.
    Ann Neurol. 1992 Nov;32(5):658-66 PMID: 1449246
  17. Unique monocyte subset in patients with AIDS dementia.
    Lancet. 1997 Mar 8;349(9053):692-5 PMID: 9078201
  18. Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HIV-1 encephalitis and local viral replication.
    AIDS. 1998 Jul 30;12(11):1327-32 PMID: 9708412
  19. The pathology of multiple sclerosis and its evolution.
    Philos Trans R Soc Lond B Biol Sci. 1999 Oct 29;354(1390):1635-40 PMID: 10603616
  20. T-lymphocyte entry into the central nervous system.
    J Neurosci Res. 1991 Feb;28(2):254-60 PMID: 2033653
  21. Dementia in AIDS patients: incidence and risk factors. Multicenter AIDS Cohort Study.
    Neurology. 1993 Nov;43(11):2245-52 PMID: 8232937
  22. Inflammation of the brain in Alzheimer's disease: implications for therapy.
    J Leukoc Biol. 1999 Apr;65(4):409-15 PMID: 10204568
  23. Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1.
    Science. 1990 Dec 14;250(4987):1593-6 PMID: 2148832
  24. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy.
    Nat Med. 1999 May;5(5):512-7 PMID: 10229227
  25. Immunohistochemical changes and PCR detection of HIV provirus DNA in brains of asymptomatic HIV-positive patients.
    J Neuropathol Exp Neurol. 1994 Jan;53(1):43-50 PMID: 8301319
  26. Differential cytokine expression in human blood monocyte subpopulations: a polymerase chain reaction analysis.
    Blood. 1996 Jan 1;87(1):373-7 PMID: 8547664
  27. Cerebrospinal fluid HIV RNA originates from both local CNS and systemic sources.
    Neurology. 2000 Feb 22;54(4):927-36 PMID: 10690988
  28. Elevation of CD69+ monocyte/macrophages in patients with Alzheimer's disease.
    Immunobiology. 2000 May;202(1):26-33 PMID: 10879686
  29. The effects of human immunodeficiency virus in the central nervous system.
    Adv Virus Res. 1998;50:1-47 PMID: 9520995
  30. Translating cell biology into therapeutic advances in Alzheimer's disease.
    Nature. 1999 Jun 24;399(6738 Suppl):A23-31 PMID: 10392577
  31. HIV-1 env sequence variation in brain tissue of patients with AIDS-related neurologic disease.
    J Acquir Immune Defic Syndr. 1991;4(11):1082-92 PMID: 1684385
  32. Increased human immunodeficiency virus (HIV) type 1 DNA content and quinolinic acid concentration in brain tissues from patients with HIV encephalopathy.
    J Infect Dis. 1995 Sep;172(3):638-47 PMID: 7658054
  33. Interaction of various intracellular signaling mechanisms involved in mononuclear phagocyte toxicity toward neuronal cells.
    J Leukoc Biol. 2000 Jan;67(1):127-33 PMID: 10648007
  34. Excitotoxicity and the NMDA receptor--still lethal after eight years.
    Trends Neurosci. 1995 Feb;18(2):57-8 PMID: 7537407
  35. Neuropsychological impairment in human immunodeficiency virus-infection: implications for employment. HNRC Group. HIV Neurobehavioral Research Center.
    Psychosom Med. 1994 Jan-Feb;56(1):8-17 PMID: 8197319
  36. Cytopathologic and neurochemical correlates of progression to motor/cognitive impairment in SIV-infected rhesus monkeys.
    J Neuropathol Exp Neurol. 1994 Mar;53(2):165-75 PMID: 8120538
  37. Analysis of human immunodeficiency virus type 1 gp160 sequences from a patient with HIV dementia: evidence for monocyte trafficking into brain.
    J Neurovirol. 2000 May;6 Suppl 1:S70-81 PMID: 10871768
  38. Analysis of the temporal relationship between human immunodeficiency virus type 1 quasispecies in sequential blood samples and various organs obtained at autopsy.
    J Virol. 1998 Jan;72(1):488-96 PMID: 9420250
  39. Antiretroviral drugs and the central nervous system.
    AIDS. 1998 Oct 22;12(15):1941-55 PMID: 9814862
  40. Human immunodeficiency virus and the brain: investigation of virus load and neuropathologic changes in pre-AIDS subjects.
    J Infect Dis. 1993 Oct;168(4):818-24 PMID: 8376829
  41. Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells.
    J Biol Chem. 1997 Nov 14;272(46):29390-7 PMID: 9361021
  42. Neurocognitive impairment is an independent risk factor for death in HIV infection. San Diego HIV Neurobehavioral Research Center Group.
    Arch Neurol. 1997 Apr;54(4):416-24 PMID: 9109743
  43. Drug concentration heterogeneity facilitates the evolution of drug resistance.
    Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11514-9 PMID: 9751697
  44. Bone marrow-derived elements in the central nervous system: an immunohistochemical and ultrastructural survey of rat chimeras.
    J Neuropathol Exp Neurol. 1992 May;51(3):246-56 PMID: 1583531
  45. Progressive cerebral volume loss in human immunodeficiency virus infection: a longitudinal volumetric magnetic resonance imaging study. HIV Neurobehavioral Research Center Group.
    Arch Neurol. 1998 Feb;55(2):161-8 PMID: 9482357
  46. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease.
    Glia. 1993 Jan;7(1):75-83 PMID: 8423065
  47. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection.
    Nature. 1997 May 8;387(6629):183-8 PMID: 9144289
  48. Neuropsychologic impairment in early HIV infection. A risk factor for work disability.
    Arch Neurol. 1995 May;52(5):525-30 PMID: 7733849
  49. Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy.
    Nat Med. 2000 Jul;6(7):757-61 PMID: 10888923
  50. Changes to AIDS dementia complex in the era of highly active antiretroviral therapy.
    AIDS. 1999 Jul 9;13(10):1249-53 PMID: 10416530
  51. Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l -cysteine.
    J Immunol. 2000 Apr 15;164(8):4265-70 PMID: 10754324
  52. Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia.
    J Neuroimmunol. 1999 Aug 3;98(2):185-200 PMID: 10430052
  53. Association of interleukin-1 gene polymorphisms with Alzheimer's disease.
    Ann Neurol. 2000 Mar;47(3):365-8 PMID: 10716257
  54. Independent evolution of HIV type 1 in different brain regions.
    AIDS Res Hum Retroviruses. 1999 Jun 10;15(9):811-20 PMID: 10381169
  55. Positive and sustained effects of highly active antiretroviral therapy on HIV-1-associated neurocognitive impairment.
    AIDS. 1999 Oct 1;13(14):1889-97 PMID: 10513647
  56. Immunology of multiple sclerosis.
    Clin Neurosci. 1994;2(3-4):229-45 PMID: 7749893
  57. Assessment of type 1 and type 2 cytokines in HIV type 1-infected individuals: impact of highly active antiretroviral therapy.
    AIDS Res Hum Retroviruses. 1999 Nov 20;15(17):1499-508 PMID: 10580400
  58. Serial pathogenesis study of SIV brain infection.
    J Med Primatol. 1991 Jun;20(4):211-7 PMID: 1942010
  59. Therapeutic strategies in multiple sclerosis. II. Long-term repair.
    Philos Trans R Soc Lond B Biol Sci. 1999 Oct 29;354(1390):1711-20 PMID: 10603622
  60. Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides.
    Science. 1990 Oct 12;250(4978):279-82 PMID: 2218531
  61. Neurotransmitters in cerebrospinal fluid reflect pathological activity.
    Eur J Clin Invest. 1997 Dec;27(12):1038-43 PMID: 9466133
  62. The pathology of multiple sclerosis: a historical perspective.
    J Neuroimmunol. 1999 Jul 1;98(1):37-44 PMID: 10426360
  63. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia.
    Science. 1997 Nov 14;278(5341):1291-5 PMID: 9360926
  64. The AIDS dementia complex: I. Clinical features.
    Ann Neurol. 1986 Jun;19(6):517-24 PMID: 3729308
  65. HIV-1 infected mononuclear phagocyte secretory products affect neuronal physiology leading to cellular demise: relevance for HIV-1-associated dementia.
    J Neurovirol. 2000 May;6 Suppl 1:S14-23 PMID: 10871761
  66. Chemokines--chemotactic cytokines that mediate inflammation.
    N Engl J Med. 1998 Feb 12;338(7):436-45 PMID: 9459648
  67. Chemokine and chemokine receptor expression in the central nervous system.
    J Neurovirol. 1999 Feb;5(1):13-26 PMID: 10190686
  68. Cytokine actions in the central nervous system.
    Cytokine Growth Factor Rev. 1998 Sep-Dec;9(3-4):259-75 PMID: 9918124
  69. HIV infection of choroid plexus in AIDS and asymptomatic HIV-infected patients suggests that the choroid plexus may be a reservoir of productive infection.
    J Neurovirol. 1999 Dec;5(6):670-7 PMID: 10602407
  70. Indinavir-based treatment of HIV-1 infected patients: efficacy in the central nervous system.
    AIDS. 1999 Jul 9;13(10):1227-32 PMID: 10416527
  71. Longitudinal study of inflammatory factors in serum, cerebrospinal fluid, and brain tissue in Alzheimer disease: interleukin-1beta, interleukin-6, interleukin-1 receptor antagonist, tumor necrosis factor-alpha, the soluble tumor necrosis factor receptors I and II, and alpha1-antichymotrypsin.
    Alzheimer Dis Assoc Disord. 1998 Sep;12(3):215-27 PMID: 9772027
  72. Investigation of the dynamics of the spread of human immunodeficiency virus to brain and other tissues by evolutionary analysis of sequences from the p17gag and env genes.
    J Virol. 1997 Feb;71(2):1272-80 PMID: 8995651
  73. Latent reservoirs of HIV: obstacles to the eradication of virus.
    Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):10958-61 PMID: 10500107
  74. SIV infection of macaques--modeling the progression to AIDS dementia.
    J Neurovirol. 1998 Jun;4(3):249-59 PMID: 9639068
  75. Chronologic localization of myelin-reactive cells in the lesions of relapsing EAE: implications for the study of multiple sclerosis.
    Neurology. 1993 May;43(5):1028-33 PMID: 7684116
  76. Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains.
    Ann Neurol. 1994 Nov;36(5):778-86 PMID: 7526776
  77. The pathophysiology of multiple sclerosis: the mechanisms underlying the production of symptoms and the natural history of the disease.
    Philos Trans R Soc Lond B Biol Sci. 1999 Oct 29;354(1390):1649-73 PMID: 10603618
  78. Changes in pathological findings at autopsy in AIDS cases for the last 15 years.
    AIDS. 2000 Jan 7;14(1):69-74 PMID: 10714569
  79. Alzheimer's beta-amyloid peptide 1-42 induces a phagocytic response in murine microglia.
    J Neurochem. 1998 Nov;71(5):2123-31 PMID: 9798938
  80. Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis.
    Brain Res Bull. 1998 Jul 1;46(4):281-309 PMID: 9671259
  81. The AIDS dementia complex: II. Neuropathology.
    Ann Neurol. 1986 Jun;19(6):525-35 PMID: 3014994
  82. Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis.
    Lab Invest. 1990 Aug;63(2):162-70 PMID: 1696331
  83. Excitatory amino acids as a final common pathway for neurologic disorders.
    N Engl J Med. 1994 Mar 3;330(9):613-22 PMID: 7905600
  84. Redistribution of HIV outside the lymphoid system with onset of AIDS.
    Lancet. 1994 Feb 12;343(8894):383-5 PMID: 7905551
  85. Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes.
    Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):700-4 PMID: 8570619
  86. HIV-protease inhibitors.
    N Engl J Med. 1998 Apr 30;338(18):1281-92 PMID: 9562584
  87. Neurocognitive disorders in HIV-1 infection. HNRC Group. HIV Neurobehavioral Research Center.
    Curr Top Microbiol Immunol. 1995;202:11-32 PMID: 7587358
  88. Glutamate neurotoxicity and diseases of the nervous system.
    Neuron. 1988 Oct;1(8):623-34 PMID: 2908446
  89. Mechanisms of immune injury in multiple sclerosis.
    Brain Pathol. 1996 Jul;6(3):243-57 PMID: 8864282
  90. Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy.
    Nat Med. 1999 Jun;5(6):651-5 PMID: 10371503
  91. Physiology and pathology of the blood-brain barrier: implications for microbial pathogenesis, drug delivery and neurodegenerative disorders.
    J Neurovirol. 1999 Dec;5(6):538-55 PMID: 10602396
  92. HIV infection and dementia.
    Science. 2000 Jan 28;287(5453):602-4 PMID: 10691542
  93. Genetic differences between blood- and brain-derived viral sequences from human immunodeficiency virus type 1-infected patients: evidence of conserved elements in the V3 region of the envelope protein of brain-derived sequences.
    J Virol. 1994 Nov;68(11):7467-81 PMID: 7933130
  94. In vivo compartmentalization of human immunodeficiency virus: evidence from the examination of pol sequences from autopsy tissues.
    J Virol. 1997 Mar;71(3):2059-71 PMID: 9032338
  95. Pathogenesis of SIV encephalitis. Selection and replication of neurovirulent SIV.
    Am J Pathol. 1997 Sep;151(3):793-803 PMID: 9284828
  96. The role of chronic self-propagating glial responses in neurodegeneration: implications for long-lived survivors of human immunodeficiency virus.
    J Neurovirol. 1997 Aug;3(4):241-6 PMID: 9291232
  97. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients.
    J Clin Invest. 1999 Mar;103(6):807-15 PMID: 10079101
  98. Murine brain macrophages induced NMDA receptor mediated neurotoxicity in vitro by secreting glutamate.
    Neurosci Lett. 1991 Dec 9;133(2):159-62 PMID: 1687755
  99. A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis.
    J Immunol. 1997 Apr 1;158(7):3499-510 PMID: 9120312
  100. An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis.
    J Immunol. 1995 Nov 15;155(10):5003-10 PMID: 7594507
  101. Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines size and structure of demyelinated lesions.
    Acta Neuropathol. 1988;75(6):566-76 PMID: 3259787
  102. Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia.
    Ann Neurol. 1995 Nov;38(5):755-62 PMID: 7486867
  103. Association between tumor necrosis factor-alpha and disease progression in patients with multiple sclerosis.
    N Engl J Med. 1991 Aug 15;325(7):467-72 PMID: 1852181
  104. The immunobiology of multiple sclerosis: an autoimmune disease of the central nervous system.
    Neurobiol Dis. 1999 Jun;6(3):149-66 PMID: 10408805
  105. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro.
    Ann Neurol. 1988 Apr;23(4):339-46 PMID: 3132891
  106. A randomized, double-blind trial comparing combinations of nevirapine, didanosine, and zidovudine for HIV-infected patients: the INCAS Trial. Italy, The Netherlands, Canada and Australia Study.
    JAMA. 1998 Mar 25;279(12):930-7 PMID: 9544767
  107. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy.
    Science. 1997 Nov 14;278(5341):1295-300 PMID: 9360927
  108. Simian immunodeficiency virus encephalitis in rhesus macaques is associated with rapid disease progression.
    J Neurovirol. 1998 Jun;4(3):260-8 PMID: 9639069
  109. Identification of a T cell chemotactic factor in the cerebrospinal fluid of HIV-1-infected individuals as interferon-gamma inducible protein 10.
    J Neuroimmunol. 1999 Jan 1;93(1-2):172-81 PMID: 10378881
  110. Differential modulation of cell death proteins in human brain cells by tumor necrosis factor alpha and platelet activating factor.
    J Neurosci Res. 1998 Nov 15;54(4):530-8 PMID: 9822163
  111. Localization of simian immunodeficiency virus in the central nervous system of rhesus monkeys.
    Am J Pathol. 1991 Sep;139(3):609-21 PMID: 1716047
  112. Expression of chemokine receptors by subsets of neurons in the central nervous system.
    J Immunol. 1997 Mar 15;158(6):2882-90 PMID: 9058825
  113. Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease.
    Am J Pathol. 1997 Apr;150(4):1267-74 PMID: 9094983
  114. Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia.
    Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3117-21 PMID: 9501225
  115. Highly active antiretroviral treatment in HIV infection: benefits for neuropsychological function.
    AIDS. 1998 May 28;12(8):F65-70 PMID: 9631133
  116. Leukocyte traffic in the central nervous system: the participants and their roles.
    Semin Immunol. 1999 Apr;11(2):125-37 PMID: 10329499
  117. Immunobiology of the blood-brain barrier.
    J Neurovirol. 1999 Dec;5(6):570-8 PMID: 10602398
  118. Patterns of oligodendroglia pathology in multiple sclerosis.
    Brain. 1994 Dec;117 ( Pt 6):1311-22 PMID: 7820568
  119. Microglia as mediators of inflammatory and degenerative diseases.
    Annu Rev Neurosci. 1999;22:219-40 PMID: 10202538
  120. AIDS dementia is associated with massive, activated HIV-1 infection and concomitant expression of several cytokines.
    Mol Med. 1996 May;2(3):358-66 PMID: 8784788
  121. Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors.
    J Neurovirol. 2000 Feb;6(1):84-8 PMID: 10787000
  122. Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity.
    Nat Med. 1998 Mar;4(3):291-7 PMID: 9500601
  123. Axonal transection in the lesions of multiple sclerosis.
    N Engl J Med. 1998 Jan 29;338(5):278-85 PMID: 9445407
  124. Multiple sclerosis: the disease and its manifestations.
    Philos Trans R Soc Lond B Biol Sci. 1999 Oct 29;354(1390):1615-22 PMID: 10603614
  125. Chemokines and receptors in HIV encephalitis.
    AIDS. 1998 Jun 18;12(9):1021-6 PMID: 9662198
  126. Unchanged levels of interleukins, neopterin, interferon-gamma and tumor necrosis factor-alpha in cerebrospinal fluid of patients with dementia of the Alzheimer type.
    Neurochem Int. 1999 Jun;34(6):523-30 PMID: 10402228
  127. Combination antiretroviral therapy improves psychomotor speed performance in HIV-seropositive homosexual men. Multicenter AIDS Cohort Study (MACS).
    Neurology. 1999 May 12;52(8):1640-7 PMID: 10331692
  128. Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity.
    Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14500-5 PMID: 9826729
  129. Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells.
    Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10738-41 PMID: 7479875
  130. Mechanisms of inflammation in MS tissue: adhesion molecules and chemokines.
    J Neuroimmunol. 1999 Jul 1;98(1):57-68 PMID: 10426363
  131. Human immunodeficiency virus-1-tat protein induces the cell surface expression of endothelial leukocyte adhesion molecule-1, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in human endothelial cells.
    Blood. 1997 Aug 15;90(4):1535-44 PMID: 9269771
  132. The HIV-1 associated dementia complex: a metabolic encephalopathy fueled by viral replication in mononuclear phagocytes.
    Curr Opin Neurol. 1997 Aug;10(4):319-25 PMID: 9266156
  133. Mosaic structure of the human immunodeficiency virus type 1 genome infecting lymphoid cells and the brain: evidence for frequent in vivo recombination events in the evolution of regional populations.
    J Virol. 1999 Oct;73(10):8720-31 PMID: 10482626
  134. Measuring the "viral load" in cerebrospinal fluid in human immunodeficiency virus infection: window into brain infection?
    Ann Neurol. 1997 Nov;42(5):675-8 PMID: 9392565
  135. In vitro evidence for a dual role of tumor necrosis factor-alpha in human immunodeficiency virus type 1 encephalopathy.
    Ann Neurol. 1995 Mar;37(3):381-94 PMID: 7695238
  136. Sentries at the gate: chemokines and the blood-brain barrier.
    J Neurovirol. 1999 Dec;5(6):623-34 PMID: 10602403
  137. Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. HNRC Group. The HIV Neurobehavioral Research Center.
    Ann Neurol. 1997 Dec;42(6):963-72 PMID: 9403489
  138. Failure to detect nelfinavir in the cerebrospinal fluid of HIV-1--infected patients with and without AIDS dementia complex.
    J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Jan 1;20(1):39-43 PMID: 9928728
  139. Cellular and anatomical reservoirs of HIV-1 in patients receiving potent antiretroviral combination therapy.
    JAMA. 1998 Jul 1;280(1):67-71 PMID: 9660366
  140. Neuropathology of human immunodeficiency virus infection.
    Brain Pathol. 1991 Apr;1(3):163-75 PMID: 1669705
  141. Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis.
    Am J Pathol. 1999 Dec;155(6):1915-27 PMID: 10595922
  142. Human immunodeficiency virus-infected macrophages produce soluble factors that cause histological and neurochemical alterations in cultured human brains.
    J Clin Invest. 1991 Feb;87(2):503-12 PMID: 1671392
  143. Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease.
    J Neurovirol. 1999 Feb;5(1):32-41 PMID: 10190688
  144. Relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acid.
    Brain Res. 1992 Jan 20;570(1-2):237-50 PMID: 1535532
  145. HIV therapeutics.
    Science. 1996 Jun 28;272(5270):1886-8 PMID: 8658159
  146. Chemokines in the CNS: plurifunctional mediators in diverse states.
    Trends Neurosci. 1999 Nov;22(11):504-12 PMID: 10529818
Article Info
Journal
Journal of neurovirology
Abbr.
J Neurovirol
ISSN
1355-0284
DOI
10.1080/13550280152058744
Email
dr89b@nih.gov
Published
2001-04-00
Pages
85-96
Language
English
Region
United States
NLM ID
9508123
Subset
IM
External Links
PubMed source DOI: 10.1080/13550280152058744 View journal details
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