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PMID: 10716257 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Association of interleukin-1 gene polymorphisms with Alzheimer's disease.

Annals of neurology ·Vol. 47 ·No. 3 ·2000-03-00 ·Pages 365-8

Nicoll JA, Mrak RE, Graham DI, Stewart J, Wilcock G, MacGowan S, Esiri MM, Murray LS, Dewar D, Love S, Moss T, Griffin WS

Abstract

Interleukin-1 (IL-1) is markedly overexpressed in Alzheimer's disease. We found the IL-1A 2,2 genotype in 12.9% of 232 neuropathologically confirmed Alzheimer's disease patients and 6.6% of 167 controls from four centers in the United Kingdom and United States (odds ratio, 3.0; controlled for age and for ApoE [apolipoprotein E] genotype). Homozygosity for both allele 2 of IL-1A and allele 2 of IL-1B conferred even greater risk (odds ratio, 10.8). IL-1 genotypes may confer risk for Alzheimer's disease through IL-1 overexpression and IL-1-driven neurodegenerative cascades.

MeSH Terms
Aged Aged, 80 and over Alleles Alzheimer Disease/genetics Genotype Humans Interleukin-1/genetics Polymorphism, Genetic/genetics
Chemicals
Interleukin-1
Authors & Affiliations
12 authors, click to expand affiliations / ORCID
Nicoll J A
Department of Neuropathology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland.
Mrak R E
Graham D I
Stewart J
Wilcock G
MacGowan S
Esiri M M
Murray L S
Dewar D
Love S
Moss T
Griffin W S
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Article Info
Journal
Annals of neurology
Abbr.
Ann Neurol
ISSN
0364-5134
Published
2000-03-00
Pages
365-8
Language
English
Region
United States
NLM ID
7707449
PMCID
PMC3833599
Subset
IM
Grants
Wellcome Trust · United Kingdom
NIA NIH HHS · P01 AG012411 · United States
NIA NIH HHS · AG10208 · United States
NIA NIH HHS · AG12411 · United States
Corrections
CommentIn
PMID: 10716246
CommentIn
PMID: 11079552
External Links
PubMed source PMC Full Text View journal details
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