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PMID: 10603616 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The pathology of multiple sclerosis and its evolution.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences ·Vol. 354 ·No. 1390 ·1999-10-29 ·Pages 1635-40

Lassmann H

Abstract

The pathology of multiple sclerosis (MS) was defined more than a century ago as a chronic inflammatory process which is associated with widespread primary demyelination and glial scarring. In this short review we discuss controversial issues on (i) the relationship between inflammation and demyelination, (ii) the various possible mechanisms of myelin destruction, and (iii) axonal involvement in this disease. We suggest that the disease process of MS is more complex that previously believed.

MeSH Terms
Axons/pathology Demyelinating Diseases/physiopathology Humans Immune System/physiopathology Inflammation/physiopathology Multiple Sclerosis/etiology,immunology,pathology,physiopathology,therapy Oligodendroglia/pathology T-Lymphocytes/physiology
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Lassmann H
Department of Neuroimmunology, University of Vienna, Austria. hans.lassmann@univie.ac.at
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36 references, click to expand
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Article Info
Journal
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Abbr.
Philos Trans R Soc Lond B Biol Sci
ISSN
0962-8436
DOI
10.1098/rstb.1999.0508
Email
hans.lassmann@univie.ac.at
Published
1999-10-29
Pages
1635-40
Language
English
Region
England
NLM ID
7503623
PMCID
PMC1692680
Subset
IM
External Links
PubMed source DOI: 10.1098/rstb.1999.0508 PMC Full Text View journal details
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