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PMID: 10381169 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Independent evolution of HIV type 1 in different brain regions.

AIDS research and human retroviruses ·Vol. 15 ·No. 9 ·1999-06-10 ·Pages 811-20

Shapshak P, Segal DM, Crandall KA, Fujimura RK, Zhang BT, Xin KQ, Okuda K, Petito CK, Eisdorfer C, Goodkin K

Abstract

HIV-1-associated brain pathology exhibits regional variability and we therefore studied the genetic differences in the V1-V5 domains of the HIV env gene in up to four regions of brain (frontal lobe, basal ganglia, medial temporal lobe, and nonmedial temporal lobe) from three patients. We found that in each separate brain region HIV-1 forms different quasispecies and that there is little gene flow among these regions. In further support of brain region-specific evolution of HIV-1, we analyzed amino acid signatures in these clones. In addition to known amino acid signatures associated with macrophage tropism and the lack of syncytium formation, we found 15 majority amino acid signature patterns from the V1-V5 env sequences associated with the neuroanatomical regions analyzed from the three individuals. Furthermore, on average, intrabrain genetic distances for the HIV-1 env were estimated to be much smaller than genetic distances between brain regions. Specific strains of HIV-1 may be neurotropic or neuroinvasive (replication preference in brain tissue) and may contribute to pathology, cognitive loss, and neuropsychiatric disease.

MeSH Terms
Adult Brain/pathology,virology Evolution, Molecular Female Genes, Viral HIV Envelope Protein gp120/genetics HIV Infections/pathology,virology HIV-1/classification,genetics Humans Male Peptide Fragments/genetics Phylogeny Sequence Analysis, DNA
Chemicals
HIV Envelope Protein gp120 HIV envelope protein gp120 (135-148) HIV envelope protein gp120 (305-321) Peptide Fragments
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Shapshak P
Department of Psychiatry and Behavioral Sciences, and Comprehensive Drug Research Center, University of Miami School of Medicine, Florida 33136, USA. pshapsha@med.miami.edu
Segal D M
Crandall K A
Fujimura R K
Zhang B T
Xin K Q
Okuda K
Petito C K
Eisdorfer C
Goodkin K
Article Info
Journal
AIDS research and human retroviruses
Abbr.
AIDS Res Hum Retroviruses
ISSN
0889-2229
DOI
10.1089/088922299310719
Email
pshapsha@med.miami.edu
Published
1999-06-10
Pages
811-20
Language
English
Region
United States
NLM ID
8709376
Subset
IM
Grants
NIDA NIH HHS · DA 04787 · United States
NIDA NIH HHS · DA 07909 · United States
NINDS NIH HHS · NS 31488 · United States
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GENBANK
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External Links
PubMed source DOI: 10.1089/088922299310719 View journal details
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