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PMID: 1097734 Published · ppublish English Comparative Study Journal Article

Discriminative effect of rifampin of RNA replication of various RNA bacteriophages.

Journal of virology ·Vol. 16 ·No. 2 ·1975-08-00 ·Pages 340-7

Engelberg H, Brudo I, Israeli-Reches M

Abstract

Rifampin interferes exclusively with RNA replication in vivo of the group I phages MS2, f2, and R17, whereas QbetaRNA replication is unaffected by the drug. In addition, rifampin has a discriminative effect of group I phage RNA replication. In the experimental system employed by us the antibiotic differentially interferes with the synthesis of minus RNA strands in f2, whereas it has almost no effect on the synthesis of progeny plus strands. In MS2, the drug differentially arrests the synthesis of progeny plus strands and almost fails to affect the synthesis of minus RNA strands. In R17 both steps of its RNA replication are affected by rifampin, although each step is only partially (approximately 50%) inhibited. The relation of the present results to the possible role of bacterial proteins and tertiary structure of phage RNA in the process of template recognition is discussed.

MeSH Terms
Bacterial Proteins/metabolism Cellulose Chromatography Coliphages/classification,growth & development,metabolism Escherichia coli/metabolism RNA Viruses RNA, Viral/biosynthesis Rifampin/pharmacology Virus Replication/drug effects
Chemicals
Bacterial Proteins RNA, Viral Cellulose Rifampin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Engelberg H
Brudo I
Israeli-Reches M
References (44)
44 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.16.2.340-347.1975
Published
1975-08-00
Pages
340-7
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC354673
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.16.2.340-347.1975 PMC Full Text View journal details
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