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PMID: 1091153 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Effects of intravascular clotting on the activation of the complement system: The role of the platelet.

The American journal of pathology ·Vol. 78 ·No. 3 ·1975-03-00 ·Pages 525-36

Kalowski S, Howes EL, Margaretten W, McKay DG

Abstract

Total hemolytic complement activity and the third component of complement were found to be significantly depressed in vivo in rabbits following the induction of disseminated intravascular coagulation by both thrombin and thromboplastin. Production of severe thrombocytopenia by the administration of platelet antiserum prior to the infusion of thrombin or thromboplastin partially prevented complement activation. The data show that, when clotting is triggered, complement activation takes place and that platelets are required to some extent for this reaction.

MeSH Terms

Animals Antigen-Antibody Complex Blood Platelets/drug effects,physiology Cattle Complement System Proteins Disseminated Intravascular Coagulation/blood,etiology,immunology Endotoxins Escherichia coli/immunology Female Goats/immunology Hemolysis Immune Sera Infusions, Parenteral Male Rabbits Sodium Chloride/pharmacology Thrombin/pharmacology Thromboplastin/pharmacology

Chemicals

Antigen-Antibody Complex Endotoxins Immune Sera Sodium Chloride Complement System Proteins Thromboplastin Thrombin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Kalowski S

Howes E L

Margaretten W

McKay D G

References (14)

14 references, click to expand

Rabbit C3 isolation and characterization of reactions in vitro and during in vivo antigen-antibody interaction.
Immunology. 1969 Nov;17(5):695-707 PMID: 5352752
PATHOGENIC FACTORS IN VASULAR LESIONS OF EXPERIMENTAL SERUM SICKNESS.
J Exp Med. 1965 Jul 1;122:83-98 PMID: 14325476
MOUSE BETA-1C-GLOBULIN: PRODUCTION OF ANTISERUM AND CHARACTERIZATION IN THE COMPLEMENT REACTION.
J Immunol. 1965 Jun;94:877-82 PMID: 14321431
Morphology and enumeration of human blood platelets.
J Appl Physiol. 1950 Dec;3(6):365-77 PMID: 14794596
Platelet requirement in the interaction of the complement and clotting systems.
Nat New Biol. 1972 Oct 18;239(94):208-10 PMID: 4117161
Immunological induction of increased vascular permeability. II. Two mechanisms of histamine release from rabbit platelets involving complement.
J Exp Med. 1969 Jan 1;129(1):167-84 PMID: 4178112
Interactions of the complement system with endotoxic lipopolysaccharide: consumption of each of the six terminal complement components.
J Exp Med. 1968 Nov 1;128(5):1049-57 PMID: 4176223
Complement and coagulation. Serum beta-lc-beta-la in disseminated intravascular coagulation.
Thromb Diath Haemorrh. 1972 Jul 31;27(3):389-95 PMID: 4268052
The requirement for platelets in the active Arthus reaction.
Am J Pathol. 1971 Aug;64(2):257-70 PMID: 4258952
Generation of chemotactic activity in rabbit serum by plasminogen-streptokinase mixtures.
J Exp Med. 1967 Jul 1;126(1):149-58 PMID: 4226164
Thin agarose gel immunologic methods.
Am J Clin Pathol. 1969 Jun;51(6):769-76 PMID: 4976989
The role of the platelet in the generalized Shwartzman reaction.
J Exp Med. 1969 Mar 1;129(3):585-90 PMID: 4886043
Blood coagulation initiation by a complement-mediated pathway.
J Exp Med. 1971 Dec 1;134(6):1601-7 PMID: 5166613
A blood coagulation abnormality in rabbits deficient in the sixth component of complement (C6) and its correction by purified C6.
J Exp Med. 1971 Dec 1;134(6):1591-600 PMID: 5126641

Article Info

Journal

The American journal of pathology

Abbr.

Am J Pathol

ISSN

0002-9440

Published

1975-03-00

Pages

525-36

Language

English

Region

United States

NLM ID

0370502

PMCID

PMC1913040

Subset

External Links

PubMed source PMC Full Text View journal details

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Effects of intravascular clotting on the activation of the complement system: The role of the platelet.

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