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PMID: 4176223 Published · ppublish English Journal Article

Interactions of the complement system with endotoxic lipopolysaccharide: consumption of each of the six terminal complement components.

The Journal of experimental medicine ·Vol. 128 ·No. 5 ·1968-11-01 ·Pages 1049-57

Gewurz H, Shin HS, Mergenhagen SE

Abstract

Large amounts of each C'3, C'5, C'6, C'7, C'8, and C'9 were consumed when guinea pig serum was incubated with endotoxic lipopolysaccharide, zymosan, or preformed immune complexes. Since these C' components subserve several of the biological activities which follow the injection of endotoxins into experimental animals, these experiments support the hypothesis that certain biological effects induced by endotoxins may be mediated via the C' system, and may account for some of the known similarity in the reactivities evoked by endotoxins and immune complexes in vivo.

MeSH Terms
Animals Cattle Complement Fixation Tests Complement System Proteins/analysis Endotoxins Guinea Pigs Humans Immune Sera Lipopolysaccharides Polysaccharides, Bacterial Rabbits Serum Albumin, Bovine Veillonella/analysis Zymosan gamma-Globulins
Chemicals
Endotoxins Immune Sera Lipopolysaccharides Polysaccharides, Bacterial gamma-Globulins Serum Albumin, Bovine Complement System Proteins Zymosan
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Gewurz H
Shin H S
Mergenhagen S E
References (28)
28 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.128.5.1049
Published
1968-11-01
Pages
1049-57
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2138564
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.128.5.1049 PMC Full Text View journal details
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