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PMID: 10613886 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Inorganic polyphosphate is required for motility of bacterial pathogens.

Journal of bacteriology ·Vol. 182 ·No. 1 ·2000-01-00 ·Pages 225-7

Rashid MH, Rao NN, Kornberg A

Abstract

The ppk gene encodes polyphosphate kinase (PPK), the principal enzyme in many bacteria responsible for the synthesis of inorganic polyphosphate (polyP) from ATP. A null mutation in the ppk gene of six bacterial pathogens renders them greatly impaired in motility on semisolid agar plates; this defect can be corrected by the introduction of ppk gene in trans. In view of the fact that the motility of pathogens is essential to invade and establish systemic infections in host cells, this impairment in motility suggests a crucial and essential role of PPK or polyP in bacterial pathogenesis.

MeSH Terms
Bacteria/genetics,metabolism,pathogenicity Bacterial Adhesion/genetics Escherichia coli/genetics,metabolism,pathogenicity Flagella/genetics Klebsiella pneumoniae/genetics,metabolism,pathogenicity Mutation Phosphotransferases (Phosphate Group Acceptor)/genetics,metabolism Polyphosphates/metabolism Pseudomonas aeruginosa/genetics,metabolism,pathogenicity Salmonella typhimurium/genetics,metabolism,pathogenicity Vibrio cholerae/genetics,metabolism,pathogenicity
Chemicals
Polyphosphates Phosphotransferases (Phosphate Group Acceptor) polyphosphate kinase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rashid M H
Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305, USA.
Rao N N
Kornberg A
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/JB.182.1.225-227.2000
Published
2000-01-00
Pages
225-7
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC94263
Subset
IM
External Links
PubMed source DOI: 10.1128/JB.182.1.225-227.2000 PMC Full Text View journal details
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