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Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
[中文简述(自动翻译):]  细胞凋亡是由几个核形态学变化,包括染色质浓缩和核碎裂定义。该基因编码能诱导通过胱天蛋白酶-3活化后凋亡染色质缩合,而不诱导DNA片段化的核蛋白。这种蛋白也被证明是一种拼接依赖性多蛋白外显子连接复合物(EJC)是,在上的mRNA剪接点沉积的一个组成部分,作为前mRNA剪接的结果。它因此可以涉及与剪接相关的mRNA代谢。编码不同同种型的可变剪接转录物变体已被用于这个基因说明。 [由RefSeq的,2011年10月提供]
ACIN1基因(以及对应的蛋白质)的细胞分布位置:
ACIN1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Adenocarcinoma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
| Central neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
| Bronchioloalveolar Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
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