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This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
[中文简述(自动翻译):]  这个基因编码属于丝氨酸 - 苏氨酸蛋白激酶的“无赖氨酸‘家族的蛋白质。这些家族成员缺乏在子域II中的催化赖氨酸,而是在子域的保守赖氨酸一本家族的成员函数作为跨细胞钙转运途径的正调节,并且它在胱天蛋白酶在细胞存活的增加作用-3依赖性途径。选择性剪接结果在多个抄本变形。 [由RefSeq的,2010年5月提供]
WNK3基因(以及对应的蛋白质)的细胞分布位置:
WNK3基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Autistic Disorder | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
| Mental Retardation, X-Linked | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
| Siderius X-linked mental retardation syndrome | 0.000271442 | 1 | 0 | BeFree |
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