UCP3(uncoupling protein 3 (mitochondrial, proton carrier)) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

11q13.4
基因染色体位置图

基因简述

基因简述

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]

[中文简述(自动翻译):]  线粒体解偶联蛋白（UCP）是大家庭的线粒体阴离子载体蛋白（MACP）的成员。从ATP合成与作为热量耗散能量解偶联蛋白分离氧化磷酸化，也被称为线粒体质子泄漏。解偶联蛋白促进阴离子从内转移至线粒体外膜以及从外质子的返回转移到线粒体内膜。它们还降低在哺乳动物细胞中的线粒体膜电位。不同的解偶联蛋白具有组织特异性表达;该基因是在骨骼肌主要表达。此基因的蛋白产物是假设以防止脂质诱导的氧化应激线粒体。这种基因提高表达水平时，脂肪酸用品线粒体超过其氧化能力和蛋白质能使脂肪酸从线粒体的出口。解偶联蛋白含有典型的MACPs发现三个solcar蛋白结构域。两个剪接变异体已发现了这种基因。[由RefSeq的，2008年11月提供]

OMIM数据库中对UCP3基因的介绍     Wikipedia数据库中对UCP3基因的介绍

基因序列

基因序列

UCP3基因的碱基序列：[NCBI]

基因突变

基因突变

UCP3基因的碱基突变：           显示全部snp
rs15763       rs632437       rs647126       rs826078       rs826079       rs826080       rs1565125       rs1618727       rs1626521       rs1685325       rs1685326       rs1685354       rs1685355       rs1685356       rs1726743       rs1726745       rs1726747       rs1800006       rs1800849       rs2075576       rs2075577       rs2229706       rs2229707       rs2632721       rs2632722       rs2632723       rs2734827       rs2734828       rs2734829       rs2736093       rs2736095       rs2736096       rs3741134       rs3741135       rs3781907       rs6413538       rs6413539      
rs7125374       rs7930460       rs8179179       rs8179180       rs9804602       rs10219224       rs11235970       rs11235971       rs11235972       rs11235973       rs11372420       rs11823911       rs12576170       rs12790150       rs17132555       rs17132562       rs17132567       rs17848365       rs17848366       rs17848367       rs17848368       rs17848372       rs35517703       rs36207413       rs36207715       rs36207717       rs45476292       rs45480799       rs45554534       rs58614015       rs70965454       rs70965455       rs70965456       rs71469490       rs72984809       rs73552716       rs73552726       rs74907838       rs75383237       rs75865407       rs75971391       rs76141067       rs76340907       rs76629964       rs76833611       rs76901368       rs77012485       rs78232574       rs78604943       rs79212763       rs79214371       rs79530724       rs104894319       rs111611286       rs111696112       rs111764612       rs111989233       rs112418145       rs113415753       rs114669689       rs114702317       rs114945084       rs115422125       rs115593841       rs115601227       rs115869804       rs115916638       rs115943555       rs116154731       rs116283965       rs116676114       rs117163429       rs117552079       rs117811004       rs138003678       rs138025219       rs138090151       rs138349065       rs138565412       rs138638665       rs138705669       rs139001347       rs139067754       rs139328626       rs139398702       rs139405752       rs140204669       rs140453737       rs140567904       rs140595048       rs140869187       rs141151790       rs141482270       rs142098686       rs142107918       rs142148844       rs142188533       rs142927779       rs142952570       rs143098507       rs143470338       rs143519626       rs143552025       rs143643530       rs143673013       rs143786748       rs144251172       rs144588006       rs144851584       rs144930392       rs145163696       rs145171105       rs145517614       rs145630133       rs145631358       rs145884716       rs146131910       rs146351427       rs146797700       rs146814014       rs146858543       rs147631608       rs147641466       rs147975989       rs148094938       rs148573606       rs148720897       rs148847746       rs149193327       rs149235168       rs149588425       rs149639341       rs149976883       rs150016118       rs150067246       rs150286432       rs150319658       rs150518474       rs150693088       rs151034480       rs180764258       rs181052900       rs181450947       rs181883754       rs181909478       rs182421337       rs182913075       rs183361796       rs183375937       rs183568044       rs183714776       rs184136454       rs184184927       rs184645665       rs185373464       rs185939721       rs186455352       rs186530793       rs187060822       rs187407290       rs187812019       rs188057078       rs188133168       rs188167539       rs188692341       rs189449740       rs190236617       rs190871280       rs190998557       rs191025701       rs191117708       rs191297129       rs191756395       rs192095265       rs192533625       rs192655642       rs192942848       rs199679366       rs199727434       rs199928418       rs199939445       rs199959534       rs200067883       rs200938041       rs201032231       rs201084007       rs201405748       rs201532497       rs201580635       rs201679589       rs201948640       rs201993988       rs202151585       rs367566750       rs368039089       rs368049853       rs368371995       rs368564754       rs368703422       rs369366489       rs369672783       rs369886256       rs369965819       rs370212766       rs370339534       rs370829405       rs371082684       rs371086941       rs371361898       rs371369161       rs371947420       rs371955058       rs372170217       rs372722476       rs372897619       rs373165822       rs373468564       rs374236390       rs374496829       rs374602264       rs375349129       rs375351281       rs375772981       rs375891548       rs376121252       rs376385271       rs376706073       rs376848921       rs376861140       rs377127401       rs377261313       rs377284289       rs377428955       rs397815485       rs527415388       rs527551014       rs527551187       rs527891486       rs528438966       rs529162540       rs529226328       rs529342950       rs529696644       rs529845110       rs530251368       rs530999429       rs531885262       rs531931105       rs531949202       rs532065902       rs532141506       rs532217600       rs532637907       rs533427241       rs533863302       rs533984618       rs534372599       rs534652633       rs535012707       rs535601404       rs535838211       rs535934382       rs536246620       rs536438768       rs536504852       rs536572526       rs537710706       rs538026766       rs538034037       rs538169571       rs538513759       rs538844271       rs538959655       rs539154531       rs539247156       rs540216698       rs540316325       rs540327173       rs540349562       rs540748077       rs540938609       rs541959514       rs542112396       rs542389983       rs543001530       rs544065090       rs544331067       rs544545178       rs545345588       rs545776773       rs545866603       rs545918090       rs545925427       rs546498077       rs546725792       rs546729912       rs546896509       rs547038288       rs547300928       rs547822671       rs547849248       rs547953085       rs548098976       rs548148205       rs548400850       rs548475830       rs548541496       rs549924322       rs550013535       rs550507571       rs550813773       rs551651246       rs551924095       rs552279288       rs552472433       rs552967403       rs553040397       rs553186689       rs554072125       rs554857036       rs555510878       rs555830581       rs556237795       rs556313362       rs557293646       rs557376645       rs558223370       rs558430525       rs558703140       rs559461087       rs560208096       rs560211425       rs560278122       rs561168334       rs561687552       rs562401311       rs562462961       rs562598827       rs562833340       rs562999909       rs563168194       rs563188018       rs563431779       rs564032921       rs564695156       rs564697218       rs565167227       rs565763273       rs566426104       rs566488211       rs566555219       rs566561051       rs566674900       rs567234076       rs567355298       rs567608903       rs567929397       rs568061207       rs568114002       rs569117370       rs569128619       rs569451034       rs569770900       rs570176621       rs570331522       rs570572619       rs570706058       rs570905334       rs571622779       rs571759636       rs571784300       rs572331438       rs572404732       rs572488103       rs572893477       rs573078341       rs573153002       rs573155963       rs573218240       rs573567746       rs573592783       rs574161323       rs574259862       rs574631794       rs575401984       rs575619046       rs576395656       rs576649266       rs576830912       rs576905145       rs576965964       rs577021400       rs577364090       rs578223492       rs745356543       rs745398031       rs745517663       rs745629298       rs745655557       rs745773835       rs745890211       rs745968021       rs746348453       rs746533067       rs746657933       rs746942942       rs746995996       rs747007884       rs747092904       rs747113663       rs747238354       rs747328082       rs747722881       rs747969322       rs748364818       rs748417606       rs748496766       rs748751232       rs748785039       rs748816217       rs748844402       rs748878337       rs749122889       rs749496001       rs749678730       rs749686100       rs750127134       rs750225036       rs750345643       rs750367534       rs750818958       rs751148074       rs751201111       rs751781640       rs751874952       rs751929969       rs752051251       rs752284285       rs752335651       rs752412908       rs752441750       rs752571562       rs752808421       rs753004564       rs753185649       rs753283122       rs753470382       rs753515876       rs753543579       rs753566053       rs753714776       rs754054591       rs754174612       rs754224798       rs754295074       rs754417229       rs754444951       rs754562888       rs754600637       rs754699467       rs754777521       rs754821951       rs755409260       rs755461584       rs755640693       rs755692022       rs755701516       rs755745742       rs755844309       rs755928179       rs755968037       rs756056155       rs756205603       rs756205653       rs756329951       rs756720503       rs756721587       rs756938226       rs757046125       rs757325030       rs757526268       rs757685199       rs757686405       rs757911503       rs757926172       rs758429452       rs758665700       rs758805473       rs759010575       rs759237683       rs759451645       rs759641502       rs759937307       rs760061491       rs760062443       rs760134386       rs760546477       rs760583982       rs760694580       rs760955370       rs761032316       rs761138117       rs761212337       rs761288449       rs761327275       rs761660712       rs761843138       rs761894617       rs761967055       rs762285444       rs762676242       rs762770256       rs762865817       rs763005583       rs763025389       rs763087706       rs763567764       rs763793623       rs763794353       rs763845388       rs764423149       rs764603117       rs764798439       rs764912790       rs764930928       rs764983743       rs765008878       rs765404524       rs765633988       rs765673001       rs765735895       rs765857744       rs765958932       rs766251292       rs766306172       rs766573609       rs766648507       rs766890961       rs766985024       rs767571905       rs767795822       rs767838103       rs767985044       rs768018002       rs768277048       rs768773047       rs768899768       rs769029996       rs769174792       rs769183491       rs769574829       rs769726795       rs769915621       rs770281351       rs770412541       rs770459075       rs770465692       rs770605050       rs770841304       rs770856245       rs771739253       rs771785449       rs771978130       rs772031012       rs772178806       rs772216802       rs772301535       rs772570438       rs772672705       rs772798840       rs773117289       rs773117397       rs773252105       rs773606533       rs773658350       rs773942980       rs774215070       rs774318484       rs774495218       rs774566400       rs774754409       rs775236986       rs775326188       rs775466630       rs775725762       rs776020758       rs776144363       rs776270448       rs776490565       rs776933539       rs777056705       rs777058329       rs777079174       rs777203090       rs777336013       rs777390546       rs777632209       rs777659543       rs777883919       rs777919456       rs777928800       rs777965664       rs777981481       rs778531573       rs778576037       rs778756494       rs779123450       rs779340479       rs779409940       rs779487396       rs779631979       rs779715171       rs779791876       rs779916199       rs780212008       rs780758930       rs780765847       rs781005518       rs781146737       rs781234478       rs781629592       rs116154731       rs570572619      

基因表达

基因表达

UCP3基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GCCTAACACAGTAACCCGT
60
GAACATCACCACGTTCCAG
59
CATGGCTGTGAAGTTCCTG
59
AAAGGTAACGAGGTCAGCA
59
CATGGCTGTGAAGTTCCTG
59
GAAAGGTAACGAGGTCAGC
58
CTAACACAGTAACCCGTCTC
58
GAACATCACCACGTTCCAG
59
CATGGCTGTGAAGTTCCTG
59
GGAAAGGTAACGAGGTCAG
58
CCTAACACAGTAACCCGTC
58
GAACATCACCACGTTCCAG
59
ATACAGCGGGACTATGGAC
59
TTGGGCAAAGTTCCTTTCC
59
AATACAGCGGGACTATGGAC
59
TGGGCAAAGTTCCTTTCCA
60
AAATACAGCGGGACTATGGA
59
GGGCAAAGTTCCTTTCCAC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

UCP3基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

UCP3基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0006839
F5H3N5(UniProtKB)
IEA
GO:0016021
F5H3N5(UniProtKB)
IEA
GO:0031966
F5H3N5(UniProtKB)
IEA
GO:0000303
P55916(UniProtKB)
IEA
GO:0000303
P55916(UniProtKB)
IEA
GO:0001666
P55916(UniProtKB)
IEA
GO:0003735
P55916(UniProtKB)
IBA
GO:0005215
P55916(UniProtKB)
TAS
GO:0005515
P55916(UniProtKB)
IPI
GO:0005739
P55916(UniProtKB)
TAS
GO:0005743
P55916(UniProtKB)
TAS
GO:0005743
P55916(UniProtKB)
TAS
GO:0005743
P55916(UniProtKB)
TAS
GO:0005743
P55916(UniProtKB)
TAS
GO:0006412
P55916(UniProtKB)
IBA
GO:0006629
P55916(UniProtKB)
TAS
GO:0006631
P55916(UniProtKB)
IEA
GO:0006839
P55916(UniProtKB)
IEA
GO:0007568
P55916(UniProtKB)
IEA
GO:0007584
P55916(UniProtKB)
IEA
GO:0007585
P55916(UniProtKB)
TAS
GO:0009409
P55916(UniProtKB)
IEA
GO:0014823
P55916(UniProtKB)
IEA
GO:0015992
P55916(UniProtKB)
TAS
GO:0015992
P55916(UniProtKB)
TAS
GO:0016021
P55916(UniProtKB)
IEA
GO:0017077
P55916(UniProtKB)
IEA
GO:0032868
P55916(UniProtKB)
IEA
GO:0032870
P55916(UniProtKB)
IEA
GO:0051384
P55916(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控UCP3基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Obesity 0.308828155 61 12 BeFree_CTD_human_GAD_UNIPROT
Obesity, Morbid 0.122367032 1 0 CLINVAR_GAD
Prostatic Neoplasms 0.12 1 0 CTD_human
Diabetes Mellitus, Non-Insulin-Dependent 0.109185034 25 6 BeFree_GAD_LHGDN_RGD
Hyperthyroidism 0.080271442 2 0 BeFree_RGD
Diabetes Mellitus, Experimental 0.08 1 0 RGD
Heart failure 0.08 1 0 RGD
Hypertensive disease 0.08 1 0 RGD
Hypothyroidism 0.08 1 0 RGD
Myocardial Reperfusion Injury 0.08 1 0 RGD
Right Ventricular Hypertrophy 0.08 1 0 RGD
Prediabetes syndrome 0.08 1 0 RGD
hearing impairment 0.08 1 0 RGD
Overweight 0.011096779 8 0 BeFree_GAD
body mass 0.007101096 3 0 GAD
Metabolic Syndrome X 0.00554839 4 0 BeFree_GAD
Diabetic Neuropathies 0.005362824 1 0 BeFree_GAD_LHGDN
Anorexia Nervosa 0.003267234 3 0 BeFree_LHGDN
Diabetes Mellitus 0.003257302 12 1 BeFree
Diabetic Nephropathy 0.002995792 1 0 BeFree_LHGDN
Diabetes 0.002985861 11 0 BeFree
Anorexia 0.00272435 1 0 LHGDN
Hyperglycemia 0.00272435 1 0 LHGDN
Chronic Obstructive Airway Disease 0.002638474 2 0 BeFree_GAD
Alzheimer's Disease 0.002367032 1 0 GAD
Atherosclerosis 0.002367032 1 0 GAD
Malignant neoplasm of urinary bladder 0.002367032 1 0 GAD
Cardiovascular Diseases 0.002367032 1 0 GAD
Coronary Arteriosclerosis 0.002367032 1 0 GAD
Coronary heart disease 0.002367032 1 0 GAD
Kidney Failure, Chronic 0.002367032 1 0 GAD
Myocardial Infarction 0.002367032 1 0 GAD
Malignant neoplasm of lung 0.002367032 1 0 GAD
Sleep Apnea, Obstructive 0.002367032 1 0 GAD
Coronary Restenosis 0.002367032 1 0 GAD
Weight Loss Adverse Event 0.002367032 1 0 GAD
Obesity, Abdominal 0.000814326 3 1 BeFree
Hyperinsulinism 0.000542884 2 0 BeFree
Impaired glucose tolerance 0.000542884 2 0 BeFree
Non-alcoholic Fatty Liver Disease 0.000542884 2 0 BeFree
Coronary Artery Disease 0.000542884 2 0 BeFree
Pediatric Obesity 0.000542884 2 2 BeFree
Adenocarcinoma 0.000271442 1 0 BeFree
Amyotrophic Lateral Sclerosis 0.000271442 1 0 BeFree
Diabetes Mellitus, Insulin-Dependent 0.000271442 1 0 BeFree
Metabolic Diseases 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lymph node 0.000271442 1 0 BeFree
Thyroid Gland Spindle Cell Tumor with Thymus-Like Differentiation 0.000271442 1 0 BeFree
Chronic Kidney Diseases 0.000271442 1 5 BeFree

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