TLR8(toll-like receptor 8) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

Xp22
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  由该基因编码的蛋白是Toll样受体（TLR）家族中起着病原体识别和先天免疫激活的基础性作用的成员。 Toll样受体是高度果蝇保守到人类和共享结构和功能的相似性。他们认识到是在感染剂表达的病原体相关分子模式（PAMP），并介导的生产所必需的有效免疫的发展细胞因子。各种Toll样受体表现出不同的表达模式。此基因在肺癌和外周血白细胞中表达，并且位于靠近另一个家族成员，TLR7，在X染色体[通过的RefSeq，2008年7月提供]

OMIM数据库中对TLR8基因的介绍     Wikipedia数据库中对TLR8基因的介绍

基因序列

基因序列

TLR8基因的碱基序列：[NCBI]

基因突变

基因突变

TLR8基因的碱基突变：           显示全部snp
rs1013150       rs1013151       rs1548731       rs2109134       rs2109135       rs2159377       rs2286626       rs2407992       rs2625416       rs3747414       rs3761624       rs3764879       rs3764880       rs3827469       rs4830805       rs4830806       rs4830807       rs4830808       rs5741883       rs5741884       rs5741885       rs5741886       rs5741887       rs5741888       rs5741889       rs5741890       rs5744040       rs5744041       rs5744042       rs5744043       rs5744044       rs5744045       rs5744046       rs5744047       rs5744048       rs5744049       rs5744050      
rs5744052       rs5744053       rs5744054       rs5744055       rs5744056       rs5744057       rs5744058       rs5744059       rs5744060       rs5744061       rs5744062       rs5744063       rs5744064       rs5744065       rs5744066       rs5744067       rs5744068       rs5744069       rs5744070       rs5744071       rs5744072       rs5744073       rs5744074       rs5744075       rs5744076       rs5744077       rs5744078       rs5744079       rs5744080       rs5744081       rs5744082       rs5744083       rs5744084       rs5744085       rs5744086       rs5744087       rs5744088       rs5744089       rs5935440       rs5935442       rs5935443       rs5935444       rs5979763       rs5979764       rs6639237       rs6639238       rs7051293       rs7064111       rs10126504       rs10568250       rs11360962       rs12015397       rs12016191       rs12854750       rs16987203       rs17256081       rs56194919       rs57166818       rs62590554       rs72561730       rs72561731       rs72561732       rs72561733       rs73449605       rs73449625       rs111810872       rs112867497       rs113350476       rs113404862       rs113486282       rs113584875       rs113733877       rs113794666       rs113857470       rs113893494       rs138011053       rs138362730       rs139006461       rs139980479       rs140072246       rs140193180       rs140860810       rs141319839       rs141586578       rs142015690       rs142199983       rs142934414       rs143006523       rs143150953       rs143398711       rs143598634       rs143833698       rs143939946       rs144647258       rs144975896       rs145228654       rs145549422       rs145872564       rs146081722       rs146087227       rs146105516       rs146163865       rs146700498       rs146965588       rs147025630       rs147035006       rs147214882       rs147465988       rs147591712       rs148046494       rs148097000       rs148539975       rs148695608       rs148772263       rs148819899       rs149091458       rs149406875       rs149600337       rs149718249       rs149719319       rs149915624       rs150093959       rs150294376       rs150828176       rs150882339       rs151096932       rs151151012       rs180715176       rs180715770       rs181276326       rs181365543       rs181415824       rs181897597       rs182035048       rs182098755       rs182230128       rs182385032       rs182484458       rs182727588       rs182758052       rs183081837       rs183274858       rs183353890       rs183801068       rs184017094       rs184026632       rs184107272       rs184806389       rs185347180       rs185352944       rs185447532       rs185589355       rs185718869       rs185990061       rs186350616       rs186443761       rs186566524       rs186781715       rs186927998       rs186953247       rs187007341       rs187114984       rs187362697       rs187415632       rs187865112       rs188081128       rs188117660       rs188230755       rs188371045       rs188476979       rs188621125       rs188646994       rs189039355       rs189185536       rs189513707       rs189916649       rs190078518       rs190195425       rs190290144       rs190403348       rs190553102       rs191211705       rs191299747       rs191343831       rs191344038       rs191610937       rs191776824       rs191915027       rs192050195       rs192163599       rs192674625       rs192738668       rs193049306       rs193131573       rs199740644       rs199990267       rs200343061       rs200421327       rs200512783       rs200981848       rs201316478       rs201420509       rs201537073       rs201714832       rs201737997       rs367993513       rs368208085       rs368213008       rs368368554       rs368684132       rs369141336       rs370464823       rs371155732       rs371285063       rs371431389       rs371612841       rs372094896       rs372127380       rs373184358       rs373310390       rs373630076       rs373795061       rs374675805       rs374687057       rs375260093       rs375512332       rs375853424       rs376034872       rs376586757       rs376689229       rs377043983       rs377162567       rs377353569       rs377637956       rs377754079       rs529160939       rs529237184       rs535003296       rs539405845       rs543638648       rs545781357       rs547813491       rs549682319       rs551473463       rs561725863       rs564192651       rs565939929       rs570794757       rs572080469       rs576185229       rs745395540       rs745398681       rs745489278       rs745595672       rs745638702       rs745722261       rs745838274       rs746006131       rs746233426       rs746367315       rs746454764       rs746476830       rs746515512       rs746573283       rs746766277       rs746819165       rs747072909       rs747177467       rs747325889       rs747619703       rs747668620       rs747672778       rs747780482       rs747885410       rs747912697       rs748185441       rs748188191       rs748222941       rs748276015       rs748329233       rs748518562       rs748639229       rs748780807       rs748873950       rs748983836       rs749029168       rs749332017       rs749337390       rs749440648       rs749627393       rs749674708       rs749714140       rs749769205       rs749873996       rs749938444       rs750172469       rs750278266       rs750358899       rs750369510       rs750589747       rs750694653       rs750715531       rs750887215       rs750990801       rs751205662       rs751250239       rs751271824       rs751303110       rs751328752       rs751358728       rs751522776       rs751572253       rs751601956       rs751908196       rs751956842       rs752100391       rs752185230       rs752485646       rs752498502       rs752588455       rs752680503       rs752683730       rs752700626       rs752721263       rs753245370       rs753247296       rs753281682       rs753352631       rs753478197       rs753639022       rs753796295       rs753811496       rs754032613       rs754297567       rs754367784       rs754464014       rs754517420       rs754712471       rs754728840       rs754838022       rs754875907       rs754930032       rs755052555       rs755056936       rs755072066       rs755367827       rs755419074       rs755419261       rs755564064       rs755569200       rs755571537       rs755929264       rs756008342       rs756013561       rs756053208       rs756221140       rs756494364       rs756515654       rs756697272       rs756717092       rs756834432       rs756838168       rs756858438       rs756907617       rs757085655       rs757138965       rs757194122       rs757294209       rs757350850       rs757413718       rs757505743       rs757615848       rs757616604       rs757638983       rs758098271       rs758149498       rs758187059       rs758245369       rs758475520       rs758600163       rs758678705       rs758812660       rs758865611       rs758919240       rs759000987       rs759064119       rs759129997       rs759189396       rs759326234       rs759381194       rs759806873       rs759898435       rs759918951       rs760181376       rs760274315       rs760425880       rs760591173       rs760786710       rs760852996       rs760956470       rs761066050       rs761231910       rs761301397       rs761606382       rs761612046       rs761613635       rs761665080       rs761742368       rs761766983       rs761768519       rs761947630       rs762168480       rs762250935       rs762391594       rs762400345       rs762514004       rs762635325       rs762690986       rs762738220       rs762743970       rs762934703       rs762965940       rs762989856       rs763105912       rs763130204       rs763377055       rs763548416       rs763801920       rs763843230       rs764028497       rs764139431       rs764370198       rs764425778       rs764443515       rs764639681       rs764981009       rs765144206       rs765157064       rs765174340       rs765270552       rs765310056       rs765334709       rs765406537       rs765518000       rs765839530       rs766077025       rs766130878       rs766184252       rs766189129       rs766295451       rs766413310       rs766459937       rs766465435       rs766470317       rs766525068       rs766664187       rs766889412       rs767136181       rs767404610       rs767445184       rs767649754       rs767811815       rs767849004       rs767968184       rs768065962       rs768099609       rs768265810       rs768276219       rs768317289       rs768437851       rs768439404       rs768531771       rs768536055       rs768589293       rs768640826       rs768763743       rs768772034       rs768871999       rs768875789       rs768903389       rs768929215       rs768972500       rs769562893       rs769669207       rs769729480       rs769948077       rs769979824       rs770138768       rs770298416       rs770522284       rs770586104       rs770624249       rs770905662       rs771088322       rs771288970       rs771336512       rs771391645       rs771444889       rs771586732       rs771701848       rs771761234       rs771835782       rs771849849       rs771922060       rs771979662       rs772274007       rs772276645       rs772304152       rs772411632       rs772440962       rs772470578       rs772942912       rs772970405       rs772999502       rs773087679       rs773230832       rs773316138       rs773370542       rs773531695       rs773695749       rs773744986       rs773858000       rs773937461       rs774128314       rs774245341       rs774269874       rs774325059       rs774455202       rs774608026       rs774709279       rs774857349       rs774911402       rs774944401       rs775025279       rs775055165       rs775091824       rs775205338       rs775208023       rs775242590       rs775278409       rs775400064       rs775402059       rs775653244       rs775845314       rs775877946       rs775878822       rs776006574       rs776231606       rs776301497       rs776377358       rs776572621       rs776716364       rs776890498       rs777092674       rs777230184       rs777245589       rs777353095       rs777369333       rs777524384       rs777663347       rs777746435       rs777768009       rs777796941       rs777833370       rs777910070       rs778036369       rs778131239       rs778322896       rs778374351       rs778375164       rs778480757       rs778538275       rs778696383       rs778715906       rs779041229       rs779161724       rs779332485       rs779489237       rs779544469       rs779609476       rs779613268       rs779645774       rs779654773       rs779734140       rs779846666       rs779864671       rs780074989       rs780305680       rs780323268       rs780338776       rs780443862       rs780464965       rs780625328       rs780631934       rs780678043       rs780811405       rs780825313       rs780867753       rs781031262       rs781122400       rs781197396       rs781250746       rs781255488       rs781335361       rs781416027       rs781422955       rs781506126       rs781778459      

基因表达

基因表达

TLR8基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
ATAGAGGGTACCATTCTGCG
59
AGCATTGACGACTGAAGGA
59
AGAAACATGGTTCTCTTGACAC
59
TTAGTCTCCTTTCCCAGGC
58
TAGAGGGTACCATTCTGCG
58
CAGCATTGACGACTGAAGG
58
AGAAACATGGTTCTCTTGACAC
59
TAGTCTCCTTTCCCAGGCT
59
AGAAACATGGTTCTCTTGACAC
59
TTTAGTCTCCTTTCCCAGGC
59
TAGAGGGTACCATTCTGCG
58
AGCATTGACGACTGAAGGA
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

TLR8基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

TLR8基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000139
Q9NR97(UniProtKB)
TAS
GO:0000139
Q9NR97(UniProtKB)
TAS
GO:0001774
Q9NR97(UniProtKB)
IEA
GO:0001932
Q9NR97(UniProtKB)
IEA
GO:0002224
Q9NR97(UniProtKB)
IBA
GO:0002224
Q9NR97(UniProtKB)
TAS
GO:0002224
Q9NR97(UniProtKB)
TAS
GO:0002755
Q9NR97(UniProtKB)
IEA
GO:0003677
Q9NR97(UniProtKB)
IDA
GO:0003723
Q9NR97(UniProtKB)
TAS
GO:0003725
Q9NR97(UniProtKB)
IDA
GO:0003727
Q9NR97(UniProtKB)
IDA
GO:0004872
Q9NR97(UniProtKB)
NAS
GO:0005789
Q9NR97(UniProtKB)
TAS
GO:0005789
Q9NR97(UniProtKB)
TAS
GO:0005789
Q9NR97(UniProtKB)
TAS
GO:0006954
Q9NR97(UniProtKB)
IEA
GO:0007249
Q9NR97(UniProtKB)
IDA
GO:0008144
Q9NR97(UniProtKB)
IEA
GO:0009615
Q9NR97(UniProtKB)
IDA
GO:0010008
Q9NR97(UniProtKB)
TAS
GO:0010008
Q9NR97(UniProtKB)
TAS
GO:0010008
Q9NR97(UniProtKB)
TAS
GO:0010008
Q9NR97(UniProtKB)
TAS
GO:0010008
Q9NR97(UniProtKB)
TAS
GO:0010008
Q9NR97(UniProtKB)
TAS
GO:0010008
Q9NR97(UniProtKB)
TAS
GO:0010008
Q9NR97(UniProtKB)
TAS
GO:0010008
Q9NR97(UniProtKB)
TAS
GO:0010008
Q9NR97(UniProtKB)
TAS
GO:0010008
Q9NR97(UniProtKB)
TAS
GO:0010008
Q9NR97(UniProtKB)
TAS
GO:0010008
Q9NR97(UniProtKB)
TAS
GO:0010008
Q9NR97(UniProtKB)
TAS
GO:0010008
Q9NR97(UniProtKB)
TAS
GO:0016021
Q9NR97(UniProtKB)
IC
GO:0016064
Q9NR97(UniProtKB)
TAS
GO:0034158
Q9NR97(UniProtKB)
IEA
GO:0034162
Q9NR97(UniProtKB)
TAS
GO:0036020
Q9NR97(UniProtKB)
TAS
GO:0045078
Q9NR97(UniProtKB)
IDA
GO:0045087
Q9NR97(UniProtKB)
NAS
GO:0045089
Q9NR97(UniProtKB)
IDA
GO:0045356
Q9NR97(UniProtKB)
IDA
GO:0045359
Q9NR97(UniProtKB)
IDA
GO:0045416
Q9NR97(UniProtKB)
IMP
GO:0050707
Q9NR97(UniProtKB)
IEA
GO:0051607
Q9NR97(UniProtKB)
IMP
GO:0071260
Q9NR97(UniProtKB)
IEP

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控TLR8基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Contact Dermatitis 0.12 1 0 CTD_human
IGA Glomerulonephritis 0.12 1 0 CTD_human
Inflammation 0.007101096 3 0 GAD
Virus Diseases 0.00617715 5 0 BeFree_GAD_LHGDN
HIV Infections 0.006091273 6 0 BeFree_GAD
Asthma 0.005634266 3 0 BeFree_GAD_LHGDN
Rheumatoid Arthritis 0.005091382 2 0 GAD_LHGDN
Premature Birth 0.004734064 2 0 GAD
Tuberculosis, Pulmonary 0.003724241 5 2 BeFree_GAD
Agammaglobulinemia 0.00272435 1 0 LHGDN
RNA Virus Infections 0.00272435 1 0 LHGDN
Hemorrhagic Fever, Crimean 0.002638474 1 0 BeFree_GAD
Multiple Sclerosis 0.002638474 2 0 BeFree_GAD
Respiratory Syncytial Virus Infections 0.002638474 2 0 BeFree_GAD
Malignant neoplasm of prostate 0.002638474 2 0 BeFree_GAD
Coronary Artery Disease 0.002638474 1 0 BeFree_GAD
Bronchiolitis Obliterans 0.002367032 1 0 GAD
Bronchiolitis, Viral 0.002367032 1 0 GAD
Celiac Disease 0.002367032 1 1 GAD
Connective Tissue Diseases 0.002367032 1 0 GAD
Fetal Diseases 0.002367032 1 0 GAD
Hodgkin Disease 0.002367032 1 0 GAD
Musculoskeletal Diseases 0.002367032 1 0 GAD
Pregnancy Complications, Hematologic 0.002367032 1 0 GAD
Dermatologic disorders 0.002367032 1 0 GAD
Infection 0.002367032 1 0 GAD
Lupus Erythematosus, Systemic 0.001357209 5 2 BeFree
Autoimmune Diseases 0.000542884 2 0 BeFree
Crohn Disease 0.000542884 2 0 BeFree
Hepatitis C 0.000542884 2 0 BeFree
Herpes Simplex Infections 0.000542884 2 0 BeFree
Inflammatory Bowel Diseases 0.000542884 2 0 BeFree
X-linked agammaglobulinemia 0.000542884 2 0 BeFree
Behcet Syndrome 0.000271442 1 0 BeFree
Biliary Atresia 0.000271442 1 0 BeFree
Cardiovascular Diseases 0.000271442 1 0 BeFree
Dengue Fever 0.000271442 1 2 BeFree
Diarrhea 0.000271442 1 0 BeFree
Experimental Autoimmune Encephalomyelitis 0.000271442 1 0 BeFree
Disorder of eye 0.000271442 1 0 BeFree
Fanconi Anemia 0.000271442 1 0 BeFree
Graves Disease 0.000271442 1 0 BeFree
Hemorrhagic Fevers, Viral 0.000271442 1 0 BeFree
Hypertensive disease 0.000271442 1 0 BeFree
Lyme Disease 0.000271442 1 0 BeFree
Measles 0.000271442 1 0 BeFree
Meningoencephalitis 0.000271442 1 0 BeFree
Pericardial effusion 0.000271442 1 2 BeFree
Prostatic Neoplasms 0.000271442 1 0 BeFree
Psoriasis 0.000271442 1 0 BeFree
Rotavirus Infections 0.000271442 1 0 BeFree
Systemic Scleroderma 0.000271442 1 0 BeFree
Septicemia 0.000271442 1 0 BeFree
Post-Traumatic Stress Disorder 0.000271442 1 0 BeFree
Tuberculosis 0.000271442 1 1 BeFree
Pleural Effusion, Malignant 0.000271442 1 0 BeFree
Polyendocrinopathies, Autoimmune 0.000271442 1 0 BeFree
Active tuberculosis 0.000271442 1 1 BeFree
Sepsis 0.000271442 1 0 BeFree
Acute HIV infection 0.000271442 1 0 BeFree
Osteoarthritis, Knee 0.000271442 1 2 BeFree
Lupus Erythematosus 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Ischemic stroke 0.000271442 1 0 BeFree
Ischemic Cerebrovascular Accident 0.000271442 1 0 BeFree
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) 0.000271442 1 0 BeFree

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