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This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因属于TIMP基因家族。由该基因家族编码的蛋白质是基质金属蛋白酶,一组涉及在细胞外基质(ECM)的降解肽酶的抑制剂。这个基因的表达响应于促有丝分裂的刺激被诱导,这导蛋白结构域的蛋白质被定位到ECM。在这种基因突变与常染色体显性遗传疾病索斯比的眼底营养不良相关联。 [由RefSeq的,2008年7月提供]
TIMP3基因(以及对应的蛋白质)的细胞分布位置:
TIMP3基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| FUNDUS DYSTROPHY, PSEUDOINFLAMMATORY, OF SORSBY | 0.32 | 5 | 0 | CTD_human_MGD_UNIPROT |
| Sorsby's fundus dystrophy | 0.124614512 | 17 | 1 | BeFree_ORPHANET |
| Asthma | 0.120542884 | 2 | 0 | BeFree_CTD_human |
| Colitis | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Spontaneous abortion | 0.12 | 1 | 0 | CTD_human |
| Urinary Bladder Diseases | 0.12 | 1 | 0 | CTD_human |
| Liver diseases | 0.12 | 1 | 0 | CTD_human |
| Neoplasm Invasiveness | 0.12 | 1 | 0 | CTD_human |
| Schistosomiasis | 0.12 | 1 | 0 | CTD_human |
| Stomach Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Neurotoxicity Syndromes | 0.12 | 1 | 0 | CTD_human |
| Experimental Autoimmune Encephalomyelitis | 0.08 | 1 | 0 | RGD |
| Reperfusion Injury | 0.08 | 1 | 0 | RGD |
| Wallerian Degeneration | 0.08 | 1 | 0 | RGD |
| Endotoxemia | 0.08 | 1 | 0 | RGD |
| Squamous cell carcinoma | 0.012526052 | 9 | 0 | BeFree_LHGDN |
| Neoplasm Metastasis | 0.01114898 | 22 | 0 | BeFree_LHGDN |
| Adenocarcinoma | 0.010073144 | 8 | 0 | BeFree_LHGDN |
| Age related macular degeneration | 0.008348685 | 12 | 2 | BeFree_GAD_LHGDN |
| Malignant neoplasm of breast | 0.008262808 | 14 | 0 | BeFree_GAD |
| Premature Birth | 0.007101096 | 3 | 0 | GAD |
| melanoma | 0.007077352 | 8 | 0 | BeFree_LHGDN |
| Mammary Neoplasms | 0.005991584 | 4 | 0 | BeFree_LHGDN |
| Prostatic Neoplasms | 0.005720142 | 3 | 0 | BeFree_LHGDN |
| Aortic Aneurysm, Abdominal | 0.005362824 | 2 | 0 | BeFree_GAD_LHGDN |
| Inflammation | 0.004734064 | 2 | 0 | GAD |
| Breast Carcinoma | 0.004071628 | 15 | 0 | BeFree |
| Choriocarcinoma | 0.003538676 | 3 | 0 | BeFree_LHGDN |
| Glioma | 0.003538676 | 4 | 0 | BeFree_LHGDN |
| Rheumatoid Arthritis | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Diabetic Retinopathy | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Liver carcinoma | 0.003257302 | 12 | 0 | BeFree |
| Retinal Diseases | 0.003181358 | 4 | 0 | BeFree_GAD |
| Malignant neoplasm of ovary | 0.003181358 | 4 | 0 | BeFree_GAD |
| Amyotrophic Lateral Sclerosis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Heart failure | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Lung Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Neurodegenerative Disorders | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Idiopathic Pulmonary Fibrosis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Carcinogenesis | 0.002985861 | 11 | 0 | BeFree |
| Intracranial Aneurysm | 0.00272435 | 1 | 0 | LHGDN |
| Lymphangioleiomyomatosis | 0.00272435 | 1 | 0 | LHGDN |
| Malignant neoplasm of stomach | 0.002714419 | 10 | 0 | BeFree |
| Stomach Carcinoma | 0.002714419 | 10 | 0 | BeFree |
| Liver Cirrhosis | 0.002638474 | 2 | 0 | BeFree_GAD |
| Carotid Artery Diseases | 0.002367032 | 1 | 0 | GAD |
| Carotid Stenosis | 0.002367032 | 1 | 0 | GAD |
| Cleft Lip | 0.002367032 | 1 | 0 | GAD |
| Cleft Palate | 0.002367032 | 1 | 0 | GAD |
| Connective Tissue Diseases | 0.002367032 | 1 | 0 | GAD |
| Coronary heart disease | 0.002367032 | 1 | 0 | GAD |
| Diabetic Angiopathies | 0.002367032 | 1 | 0 | GAD |
| Fetal Diseases | 0.002367032 | 1 | 0 | GAD |
| Hypertensive disease | 0.002367032 | 1 | 0 | GAD |
| Lymphoma, Non-Hodgkin | 0.002367032 | 1 | 0 | GAD |
| Musculoskeletal Diseases | 0.002367032 | 1 | 0 | GAD |
| Myocardial Infarction | 0.002367032 | 1 | 0 | GAD |
| Pregnancy Complications, Hematologic | 0.002367032 | 1 | 0 | GAD |
| Pulmonary Fibrosis | 0.002367032 | 1 | 0 | GAD |
| Dermatologic disorders | 0.002367032 | 1 | 0 | GAD |
| Hepatitis C, Chronic | 0.002367032 | 1 | 0 | GAD |
| Choroidal Neovascularization | 0.002367032 | 1 | 0 | GAD |
| Geographic Atrophy | 0.002367032 | 1 | 0 | GAD |
| Infection | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of prostate | 0.002171535 | 8 | 0 | BeFree |
| Prostate carcinoma | 0.002171535 | 8 | 0 | BeFree |
| Colorectal Cancer | 0.001900093 | 7 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.001628651 | 6 | 0 | BeFree |
| Colorectal Carcinoma | 0.001628651 | 6 | 0 | BeFree |
| Glioblastoma | 0.001628651 | 6 | 0 | BeFree |
| Malignant neoplasm of lung | 0.001628651 | 6 | 0 | BeFree |
| Carcinoma of lung | 0.001628651 | 6 | 0 | BeFree |
| Aortic Aneurysm | 0.001357209 | 5 | 7 | BeFree |
| Secondary malignant neoplasm of liver | 0.001357209 | 5 | 0 | BeFree |
| Periodontitis | 0.001085767 | 4 | 0 | BeFree |
| Cervix carcinoma | 0.001085767 | 4 | 1 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.001085767 | 4 | 0 | BeFree |
| Degenerative disorder | 0.001085767 | 4 | 0 | BeFree |
| Arteriosclerosis | 0.000814326 | 3 | 0 | BeFree |
| Atherosclerosis | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of urinary bladder | 0.000814326 | 3 | 6 | BeFree |
| Renal Cell Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Inflammatory Bowel Diseases | 0.000814326 | 3 | 0 | BeFree |
| Keratoconus | 0.000814326 | 3 | 0 | BeFree |
| Meningioma | 0.000814326 | 3 | 0 | BeFree |
| Ovarian Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Retinitis Pigmentosa | 0.000814326 | 3 | 0 | BeFree |
| Adenocarcinoma Of Esophagus | 0.000814326 | 3 | 0 | BeFree |
| Endometrial Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000814326 | 3 | 0 | BeFree |
| Carcinoma of bladder | 0.000814326 | 3 | 6 | BeFree |
| Disorder of macula of retina | 0.000814326 | 3 | 0 | BeFree |
| Adenoma | 0.000542884 | 2 | 0 | BeFree |
| Aneurysm | 0.000542884 | 2 | 0 | BeFree |
| Malignant tumor of cervix | 0.000542884 | 2 | 0 | BeFree |
| Diabetes Mellitus | 0.000542884 | 2 | 0 | BeFree |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.000542884 | 2 | 0 | BeFree |
| Diabetic Nephropathy | 0.000542884 | 2 | 0 | BeFree |
| Gingival Diseases | 0.000542884 | 2 | 0 | BeFree |
| Liver neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Macular degeneration | 0.000542884 | 2 | 0 | BeFree |
| Psoriasis | 0.000542884 | 2 | 0 | BeFree |
| Retinal Degeneration | 0.000542884 | 2 | 0 | BeFree |
| Severe Combined Immunodeficiency | 0.000542884 | 2 | 0 | BeFree |
| Intervertebral Disc Degeneration | 0.000542884 | 2 | 0 | BeFree |
| Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
| Uveal melanoma | 0.000542884 | 2 | 0 | BeFree |
| Papillary thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Cancer of Head and Neck | 0.000542884 | 2 | 0 | BeFree |
| Squamous cell carcinoma of esophagus | 0.000542884 | 2 | 0 | BeFree |
| Solid tumour | 0.000542884 | 2 | 0 | BeFree |
| Tumor necrosis | 0.000542884 | 2 | 0 | BeFree |
| Thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Meningioma, benign, no ICD-O subtype | 0.000542884 | 2 | 0 | BeFree |
| BIETTI CRYSTALLINE CORNEORETINAL DYSTROPHY | 0.000542884 | 2 | 0 | BeFree |
| Unspecified visual loss | 0.000542884 | 2 | 0 | BeFree |
| Carcinoid Tumor | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma, Scirrhous | 0.000271442 | 1 | 0 | BeFree |
| Cardiomyopathy, Dilated | 0.000271442 | 1 | 0 | BeFree |
| Bronchitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Crohn Disease | 0.000271442 | 1 | 0 | BeFree |
| Scleroderma | 0.000271442 | 1 | 0 | BeFree |
| Diabetes | 0.000271442 | 1 | 0 | BeFree |
| Diabetes Mellitus, Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
| Eclampsia | 0.000271442 | 1 | 0 | BeFree |
| Endometriosis | 0.000271442 | 1 | 0 | BeFree |
| granulosa cell tumor | 0.000271442 | 1 | 0 | BeFree |
| Congestive heart failure | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, Plasma Cell | 0.000271442 | 1 | 0 | BeFree |
| Marfan Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Medulloblastoma | 0.000271442 | 1 | 0 | BeFree |
| Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
| Muscular Dystrophy | 0.000271442 | 1 | 0 | BeFree |
| Myopia | 0.000271442 | 1 | 0 | BeFree |
| Night Blindness | 0.000271442 | 1 | 0 | BeFree |
| Obesity | 0.000271442 | 1 | 0 | BeFree |
| Periodontal Diseases | 0.000271442 | 1 | 0 | BeFree |
| Pigeon Breeder's Lung | 0.000271442 | 1 | 0 | BeFree |
| Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
| Cerebrovascular accident | 0.000271442 | 1 | 0 | BeFree |
| Subarachnoid Hemorrhage | 0.000271442 | 1 | 0 | BeFree |
| Varicosity | 0.000271442 | 1 | 0 | BeFree |
| Synovial Cyst | 0.000271442 | 1 | 0 | BeFree |
| Pyoderma Gangrenosum | 0.000271442 | 1 | 0 | BeFree |
| Cutaneous Melanoma | 0.000271442 | 1 | 0 | BeFree |
| Corneal pannus | 0.000271442 | 1 | 0 | BeFree |
| Aortic Aneurysm, Thoracic | 0.000271442 | 1 | 0 | BeFree |
| Anaplastic carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Undifferentiated carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Diabetic Foot | 0.000271442 | 1 | 0 | BeFree |
| Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Muscular Dystrophy, Facioscapulohumeral | 0.000271442 | 1 | 0 | BeFree |
| Mucosa-Associated Lymphoid Tissue Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Cerebral Vasospasm | 0.000271442 | 1 | 0 | BeFree |
| Chronic Periodontitis | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
| Cervical Squamous Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Conventional (Clear Cell) Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of oropharynx | 0.000271442 | 1 | 0 | BeFree |
| Diffuse Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
| Anaplastic Ependymoma | 0.000271442 | 1 | 0 | BeFree |
| Grade III Meningioma | 0.000271442 | 1 | 0 | BeFree |
| Benign Meningioma | 0.000271442 | 1 | 0 | BeFree |
| Hereditary macular dystrophy | 0.000271442 | 1 | 0 | BeFree |
| High altitude pulmonary edema | 0.000271442 | 1 | 1 | BeFree |
| Dissection of aorta | 0.000271442 | 1 | 0 | BeFree |
| Multiple malignancy | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary lymphangioleiomyomatosis | 0.000271442 | 1 | 0 | BeFree |
| Recurrent tumor | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of esophagus | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of mouth | 0.000271442 | 1 | 0 | BeFree |
| Recurrent pneumonia | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Dissecting aneurysm of the thoracic aorta | 0.000271442 | 1 | 0 | BeFree |
| Macular dystrophy | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of kidney | 0.000271442 | 1 | 0 | BeFree |
| Adenomatous polyp of colon | 0.000271442 | 1 | 0 | BeFree |
| Cerebral Ischemia | 0.000271442 | 1 | 0 | BeFree |
| Vascular inflammations | 0.000271442 | 1 | 0 | BeFree |
| Ductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Myxoid cyst | 0.000271442 | 1 | 0 | BeFree |
| Drusen | 0.000271442 | 1 | 0 | BeFree |
| Papillary Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of the gastroesophageal junction | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Diabetic foot ulcer | 0.000271442 | 1 | 0 | BeFree |
| grade I meningioma | 0.000271442 | 1 | 0 | BeFree |
| Secondary Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
| Tumor Angiogenesis | 0.000271442 | 1 | 0 | BeFree |
| Tumor Expansion | 0.000271442 | 1 | 0 | BeFree |
| Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
| Ductal Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Central areolar choroidal sclerosis | 0.000271442 | 1 | 0 | BeFree |
| Tendinosis | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
| Adult-Onset Vitelliform Macular Dystrophy | 0.000271442 | 1 | 0 | BeFree |
| Malattia Leventinese | 0.000271442 | 1 | 0 | BeFree |
| LATE-ONSET RETINAL DEGENERATION (disorder) | 0.000271442 | 1 | 0 | BeFree |
| AMYOTROPHIC LATERAL SCLEROSIS 1 | 0.000271442 | 1 | 0 | BeFree |
| PNEUMOTHORAX, PRIMARY SPONTANEOUS | 0.000271442 | 1 | 0 | BeFree |
| Photoreceptor degeneration | 0.000271442 | 1 | 0 | BeFree |
| Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Nonalcoholic Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
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