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Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  转谷氨酰胺酶是催化蛋白质由小量,γ-谷氨酰赖氨酸异肽键交联的酶。而转谷氨酰胺酶的一级结构是不保守的,它们都具有相同的氨基酸序列在它们的活性位点和它们的活性是钙依赖性。由该基因编码的蛋白质用作单体,由视黄酸诱发的,并且似乎参与细胞凋亡。最后,所编码的蛋白质是在腹腔疾病牵连的自身抗原。已发现该基因编码不同亚型的两个转录变异体。 [由RefSeq的,2008年7月提供]
TGM2基因(以及对应的蛋白质)的细胞分布位置:
TGM2基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Celiac Disease | 0.153698518 | 89 | 0 | BeFree_CTD_human_LHGDN |
| Mammary Neoplasms | 0.137431869 | 10 | 0 | BeFree_CTD_human_LHGDN |
| Renal Cell Carcinoma | 0.121085767 | 5 | 0 | BeFree_CTD_human |
| Brain Neoplasms | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Glioblastoma | 0.120271442 | 3 | 0 | BeFree_CTD_human |
| Degenerative polyarthritis | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Esophageal Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Hypertensive disease | 0.12 | 1 | 0 | CTD_human |
| Maturity onset diabetes mellitus in young | 0.080542884 | 2 | 0 | BeFree_MGD |
| Left Ventricular Hypertrophy | 0.08 | 1 | 0 | RGD |
| Neoplasm Metastasis | 0.007338862 | 18 | 0 | BeFree_LHGDN |
| Huntington Disease | 0.006534468 | 5 | 0 | BeFree_LHGDN |
| Adenocarcinoma | 0.005991584 | 4 | 0 | BeFree_LHGDN |
| Dermatomyositis | 0.005720142 | 2 | 0 | BeFree_LHGDN |
| Polymyositis | 0.005720142 | 2 | 0 | BeFree_LHGDN |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.005634266 | 2 | 0 | BeFree_GAD_LHGDN |
| Malignant neoplasm of breast | 0.004885954 | 18 | 1 | BeFree |
| Breast Carcinoma | 0.004885954 | 18 | 1 | BeFree |
| ovarian neoplasm | 0.003810118 | 5 | 0 | BeFree_LHGDN |
| Dermatitis Herpetiformis | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| melanoma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Myeloid Leukemia, Chronic | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Meningioma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Schizophrenia | 0.002909916 | 2 | 0 | BeFree_GAD |
| Inflammation | 0.00272435 | 1 | 0 | LHGDN |
| Oral Submucous Fibrosis | 0.00272435 | 1 | 0 | LHGDN |
| Pancreatic Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Virus Diseases | 0.00272435 | 1 | 0 | LHGDN |
| Atrophic | 0.00272435 | 1 | 0 | LHGDN |
| Nephrogenic Fibrosing Dermopathy | 0.00272435 | 1 | 0 | LHGDN |
| Neuroblastoma | 0.002714419 | 10 | 0 | BeFree |
| Central neuroblastoma | 0.002714419 | 10 | 0 | BeFree |
| Exfoliation Syndrome | 0.002638474 | 2 | 0 | BeFree_GAD |
| Glaucoma, Open-Angle | 0.002367032 | 1 | 0 | GAD |
| Ovarian Carcinoma | 0.002171535 | 8 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.002171535 | 8 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.002171535 | 8 | 0 | BeFree |
| Diabetes Mellitus, Insulin-Dependent | 0.001900093 | 7 | 0 | BeFree |
| Pancreatic carcinoma | 0.001900093 | 7 | 0 | BeFree |
| Neurodegenerative Disorders | 0.001900093 | 7 | 0 | BeFree |
| Malignant neoplasm of lung | 0.001357209 | 5 | 0 | BeFree |
| Carcinoma of lung | 0.001357209 | 5 | 0 | BeFree |
| Glioma | 0.001085767 | 4 | 0 | BeFree |
| Amyotrophic Lateral Sclerosis | 0.000814326 | 3 | 1 | BeFree |
| Autoimmune Diseases | 0.000814326 | 3 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Diabetes | 0.000814326 | 3 | 0 | BeFree |
| Diabetes Mellitus | 0.000814326 | 3 | 0 | BeFree |
| Ischemia | 0.000814326 | 3 | 0 | BeFree |
| Cerebrovascular accident | 0.000814326 | 3 | 0 | BeFree |
| Aortic Aneurysm, Thoracic | 0.000814326 | 3 | 0 | BeFree |
| Tumor Progression | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000814326 | 3 | 0 | BeFree |
| Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Bipolar Disorder | 0.000542884 | 2 | 1 | BeFree |
| Squamous cell carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Cardiomyopathy, Dilated | 0.000542884 | 2 | 0 | BeFree |
| Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Dwarfism | 0.000542884 | 2 | 1 | BeFree |
| Fuchs Endothelial Dystrophy | 0.000542884 | 2 | 0 | BeFree |
| Glaucoma | 0.000542884 | 2 | 0 | BeFree |
| Intestinal Diseases | 0.000542884 | 2 | 0 | BeFree |
| Multiple Endocrine Neoplasia Type 2a | 0.000542884 | 2 | 0 | BeFree |
| Multiple Endocrine Neoplasia Type 2b | 0.000542884 | 2 | 0 | BeFree |
| Muscular Dystrophy | 0.000542884 | 2 | 1 | BeFree |
| Myositis | 0.000542884 | 2 | 0 | BeFree |
| Progressive supranuclear palsy | 0.000542884 | 2 | 0 | BeFree |
| Testicular Feminization | 0.000542884 | 2 | 0 | BeFree |
| Pancreatic Ductal Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
| Xenograft Model | 0.000542884 | 2 | 0 | BeFree |
| Colorectal Cancer | 0.000542884 | 2 | 0 | BeFree |
| Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Alcoholic Steatohepatitis | 0.000542884 | 2 | 0 | BeFree |
| Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Adrenal Gland Diseases | 0.000271442 | 1 | 0 | BeFree |
| Asthma | 0.000271442 | 1 | 0 | BeFree |
| Ataxia | 0.000271442 | 1 | 0 | BeFree |
| Mental disorders | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of prostate | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma, Transitional Cell | 0.000271442 | 1 | 0 | BeFree |
| Ulcerative Colitis | 0.000271442 | 1 | 0 | BeFree |
| Craniofacial Dysostosis | 0.000271442 | 1 | 0 | BeFree |
| Dry Eye Syndromes | 0.000271442 | 1 | 0 | BeFree |
| Duodenitis | 0.000271442 | 1 | 0 | BeFree |
| Fibrosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Gastrointestinal Diseases | 0.000271442 | 1 | 0 | BeFree |
| Globus Hystericus | 0.000271442 | 1 | 0 | BeFree |
| Graves Disease | 0.000271442 | 1 | 0 | BeFree |
| Hamartoma Syndrome, Multiple | 0.000271442 | 1 | 0 | BeFree |
| Von Hippel-Lindau Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Hypoglycemia | 0.000271442 | 1 | 0 | BeFree |
| Acute lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
| Acute Promyelocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| nervous system disorder | 0.000271442 | 1 | 0 | BeFree |
| Pheochromocytoma | 0.000271442 | 1 | 0 | BeFree |
| Precancerous Conditions | 0.000271442 | 1 | 0 | BeFree |
| Ectopic Pregnancy | 0.000271442 | 1 | 0 | BeFree |
| Seizures | 0.000271442 | 1 | 0 | BeFree |
| Hallopeau-Siemens Disease | 0.000271442 | 1 | 0 | BeFree |
| Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
| Plasmacytosis | 0.000271442 | 1 | 0 | BeFree |
| Cataract | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Medullary carcinoma of thyroid | 0.000271442 | 1 | 0 | BeFree |
| Fibrosis, Liver | 0.000271442 | 1 | 0 | BeFree |
| Proliferative vitreoretinopathy | 0.000271442 | 1 | 0 | BeFree |
| Xanthinuria, Type I | 0.000271442 | 1 | 0 | BeFree |
| Muscular Dystrophy, Oculopharyngeal | 0.000271442 | 1 | 0 | BeFree |
| Impaired glucose tolerance | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
| Metastatic melanoma | 0.000271442 | 1 | 0 | BeFree |
| Dryness of eye | 0.000271442 | 1 | 0 | BeFree |
| Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000271442 | 1 | 0 | BeFree |
| Amnesia, Transient Global | 0.000271442 | 1 | 0 | BeFree |
| Glaucoma, Primary Open Angle | 0.000271442 | 1 | 0 | BeFree |
| Endometriosis of uterus | 0.000271442 | 1 | 0 | BeFree |
| Multiple malignancy | 0.000271442 | 1 | 0 | BeFree |
| Disseminated Malignant Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Nuclear cataract | 0.000271442 | 1 | 0 | BeFree |
| Class III malocclusion | 0.000271442 | 1 | 0 | BeFree |
| Neuropathy | 0.000271442 | 1 | 0 | BeFree |
| Sleep Apnea, Obstructive | 0.000271442 | 1 | 0 | BeFree |
| Recurrent tumor | 0.000271442 | 1 | 0 | BeFree |
| Bilateral cataracts (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
| Brain Tumor, Primary | 0.000271442 | 1 | 0 | BeFree |
| Gluten sensitivity | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma, Pancreatic Ductal | 0.000271442 | 1 | 0 | BeFree |
| Stage IV Skin Melanoma | 0.000271442 | 1 | 0 | BeFree |
| Desmoplastic | 0.000271442 | 1 | 0 | BeFree |
| Hepatocarcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Tendinopathy | 0.000271442 | 1 | 0 | BeFree |
| Meningioma, benign, no ICD-O subtype | 0.000271442 | 1 | 0 | BeFree |
| CATARACT, ANTERIOR POLAR | 0.000271442 | 1 | 0 | BeFree |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
| Craniofacial dysostosis type 1 | 0.000271442 | 1 | 0 | BeFree |
| Nonalcoholic Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
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