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Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes an integral subunit of TFIID associated with all transcriptionally competent forms of that complex. This subunit interacts strongly with two TFIID subunits that show similarity to histones H3 and H4, and it may participate in forming a nucleosome-like core in the TFIID complex. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由RNA聚合酶II转录起始需要70多个多肽的活动。它协调这些活动的蛋白质是转录因子的IID(TFIID),其结合到核心启动子正确定位聚合酶,作为支架的转录复合物的其余部分的组件,并作为调节信号的信道。 TFIID是由TATA结合蛋白(TBP)和一组被称为TBP相关因子或TAFS进化保守的蛋白质的。 TAFS可能参与基础转录,作为共激活因子,功能的启动子识别或修改一般转录因子(基转移酶),以方便复杂的组装和转录起始。该基因编码与复杂的转录一切形式的主管相关TFIID的一个组成亚基。此亚基具有两个TFIID亚基,显示相似的组蛋白H3和H4强烈地相互作用,并且它可以参与形成在TFIID络合物的核小体样核心。 [由RefSeq的,2008年7月提供]
TAF5基因(以及对应的蛋白质)的细胞分布位置:
TAF5基因的本体(GO)信息:
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