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Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
[中文简述(自动翻译):]  硫酸乙酰肝素蛋白多糖(聚糖)作为辅助受体为许多肝素结合生长因子和细胞因子和涉及细胞信号传导。硫酸乙酰肝素6-O- endosulfatases,如SULF2,选择性地从硫酸乙酰肝素除去6-O-硫酸酯基团。此活动通过改变结合位点的信号分子(Dai等人,2005 [搜索PubMed 16192265])调制的硫酸乙酰肝素的影响。[由OMIM,2008年3月提供的]
SULF2基因(以及对应的蛋白质)的细胞分布位置:
SULF2基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Endometriosis | 0.12 | 2 | 0 | CTD_human |
| Degenerative polyarthritis | 0.003538676 | 3 | 1 | BeFree_LHGDN |
| Atrial Fibrillation | 0.002367032 | 1 | 1 | GAD |
| Inflammatory Bowel Diseases | 0.002367032 | 1 | 1 | GAD |
| Attention deficit hyperactivity disorder | 0.002367032 | 1 | 1 | GAD |
| Liver carcinoma | 0.001628651 | 6 | 0 | BeFree |
| Malignant neoplasm of breast | 0.001085767 | 4 | 0 | BeFree |
| Breast Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000814326 | 3 | 0 | BeFree |
| Neoplasm Metastasis | 0.000814326 | 3 | 0 | BeFree |
| Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
| Stomach Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Noninfiltrating Intraductal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.000542884 | 2 | 2 | BeFree |
| Invasive Ductal Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Hepatocarcinogenesis | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of skin | 0.000271442 | 1 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
| Glioma | 0.000271442 | 1 | 0 | BeFree |
| Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
| Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Obesity | 0.000271442 | 1 | 0 | BeFree |
| Pancreatitis | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of testis | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of brain | 0.000271442 | 1 | 0 | BeFree |
| Uveal melanoma | 0.000271442 | 1 | 0 | BeFree |
| Dyslipidemias | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Solid tumour | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of pancreas | 0.000271442 | 1 | 0 | BeFree |
| Comedocarcinoma, noninfiltrating | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of kidney | 0.000271442 | 1 | 0 | BeFree |
| Renal carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cardiomyopathy, Familial Idiopathic | 0.000271442 | 1 | 0 | BeFree |
| Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
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