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The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
[中文简述(自动翻译):]  由该基因编码的蛋白质是STAT蛋白家族的一个成员。响应于细胞因子和生长因子,STAT家族成员是由受体相关的激酶磷酸化,然后形成同源该转位到细胞核,其中它们作为转录激活剂或异二聚体。响应于干扰素(IFN),这种蛋白与STAT1和干扰素调节因子家族蛋白P48(ISGF3G),其中该蛋白质充当反式,但缺乏直接结合DNA的能力的复合物。转录适配器P300 / CBP(EP300 / CREBBP)已被证明与该蛋白质,这被认为是参与阻挡由腺病毒的IFN-α应答的过程特异性相互作用。已发现该基因编码不同亚型的多个抄本变形。 [由RefSeq的,2010年3月提供]
STAT2基因(以及对应的蛋白质)的细胞分布位置:
STAT2基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Psoriasis | 0.124734064 | 3 | 1 | GAD_GWASCAT |
| Inflammatory dermatosis | 0.12 | 1 | 1 | GWASCAT |
| Reperfusion Injury | 0.08 | 1 | 0 | RGD |
| Hepatitis C, Chronic | 0.007101096 | 3 | 0 | GAD |
| Asthma | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
| melanoma | 0.003538676 | 4 | 0 | BeFree_LHGDN |
| Cytomegalovirus Infections | 0.00272435 | 1 | 0 | LHGDN |
| Neutropenia | 0.002638474 | 1 | 0 | BeFree_GAD |
| Hepatitis C | 0.002367032 | 1 | 0 | GAD |
| Liver Cirrhosis | 0.002367032 | 1 | 0 | GAD |
| Multiple Sclerosis | 0.002367032 | 1 | 0 | GAD |
| Thrombocytopenia | 0.002367032 | 1 | 0 | GAD |
| Liver carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Liver neoplasms | 0.000814326 | 3 | 0 | BeFree |
| Virus Diseases | 0.000814326 | 3 | 0 | BeFree |
| Malignant tumor of colon | 0.000542884 | 2 | 0 | BeFree |
| HIV Infections | 0.000542884 | 2 | 0 | BeFree |
| Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Nasopharyngeal carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
| Myeloid Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Acute Promyelocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Leukopenia | 0.000271442 | 1 | 0 | BeFree |
| Lupus Erythematosus, Systemic | 0.000271442 | 1 | 0 | BeFree |
| Lymphocytic Choriomeningitis | 0.000271442 | 1 | 0 | BeFree |
| Measles | 0.000271442 | 1 | 0 | BeFree |
| Yellow Fever | 0.000271442 | 1 | 0 | BeFree |
| Non-arthropod borne lymphocytic choriomeningitis | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of nasopharynx | 0.000271442 | 1 | 0 | BeFree |
| Cancer of Nasopharynx | 0.000271442 | 1 | 0 | BeFree |
| Cervix carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| West Nile viral infection | 0.000271442 | 1 | 0 | BeFree |
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