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The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是Kunitz结构家族的一个成员丝氨酸蛋白酶抑制剂。该蛋白质是特异于HGF活化剂的强效抑制剂,并且被认为参与了在损伤组织的蛋白水解活化的HGF的调节。选择性剪接结果编码不同亚型多个变种。 [由RefSeq的,2008年7月提供]
SPINT1基因(以及对应的蛋白质)的细胞分布位置:
SPINT1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Liver Cirrhosis | 0.080542884 | 3 | 0 | BeFree_RGD |
| Malignant neoplasm of breast | 0.003452799 | 4 | 0 | BeFree_GAD |
| Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Gastrointestinal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Chronic Obstructive Airway Disease | 0.00272435 | 1 | 0 | LHGDN |
| Prostatic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Neoplasm Metastasis | 0.001357209 | 5 | 0 | BeFree |
| Breast Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Colorectal Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Influenza | 0.000814326 | 3 | 0 | BeFree |
| Pancreatic carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Glioblastoma | 0.000542884 | 2 | 0 | BeFree |
| Hepatitis, Chronic | 0.000542884 | 2 | 0 | BeFree |
| Liver diseases | 0.000542884 | 2 | 0 | BeFree |
| Liver neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
| Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
| Fibrosis, Liver | 0.000542884 | 2 | 0 | BeFree |
| MRSA - Methicillin resistant Staphylococcus aureus infection | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
| Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Mammary Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Cirrhosis | 0.000542884 | 2 | 0 | BeFree |
| Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Anaplasia | 0.000271442 | 1 | 0 | BeFree |
| Biliary Atresia | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of urinary bladder | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of endometrium | 0.000271442 | 1 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Fibroid Tumor | 0.000271442 | 1 | 0 | BeFree |
| Medulloblastoma | 0.000271442 | 1 | 0 | BeFree |
| Neonatal hepatitis | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Uterine Fibroids | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Leiomyosarcoma of uterus | 0.000271442 | 1 | 0 | BeFree |
| Endometrial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Hyperhomocysteinemia | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
| Colorectal cancer metastatic | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of large intestine | 0.000271442 | 1 | 0 | BeFree |
| Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
| LATERAL MENINGOCELE SYNDROME | 0.000271442 | 1 | 0 | BeFree |
| Uterine Corpus Cancer | 0.000271442 | 1 | 0 | BeFree |
| Homocysteinemia | 0.000271442 | 1 | 0 | BeFree |
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