SOST(sclerostin) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

17q12-q21
基因染色体位置图

基因简述

基因简述

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  硬化蛋白是分泌的糖蛋白具有C-末端半胱氨酸结状（CTCK）结构域和序列相似性的DAN（在神经母细胞瘤差异筛选选择的基因aberrative）家族的骨形态发生蛋白（BMP）的拮抗剂。在该基因失功能突变与常染色体隐性病症，sclerosteosis，这会导致渐进骨过度生长相关联。该基因下游的缺失，从而导致降低硬化的表达，与所谓的面包车Buchem疾病障碍的温和的形式有关。 [由RefSeq的，2008年7月提供]

OMIM数据库中对SOST基因的介绍     Wikipedia数据库中对SOST基因的介绍

基因序列

基因序列

SOST基因的碱基序列：[NCBI]

基因突变

基因突变

SOST基因的碱基突变：           显示全部snp
rs851054       rs851055       rs851056       rs851057       rs851058       rs865429       rs2023794       rs3840866       rs7218013       rs10534024       rs10570485       rs17881518       rs17881550       rs17881694       rs17882143       rs17883006       rs17883310       rs17883541       rs17885799       rs17885979       rs17886183       rs17886734       rs59613373       rs61105240       rs73987075       rs73987076       rs73987078       rs74252774       rs75335214       rs75901553       rs79715828       rs79801366       rs111517112       rs112432349       rs113282732       rs114609105       rs114649096      
rs115565514       rs116799821       rs117715527       rs117857467       rs138163431       rs138811654       rs139480227       rs139742713       rs139822050       rs139856590       rs140960915       rs141259365       rs141856582       rs143755073       rs144134625       rs144304911       rs144833747       rs145538043       rs146848252       rs147448439       rs147921758       rs148323719       rs149663855       rs149814744       rs150640883       rs181601571       rs181613562       rs181881406       rs182643322       rs182899606       rs184175301       rs184607277       rs184726172       rs185532695       rs185988382       rs187306825       rs187489473       rs187989203       rs188819432       rs189073125       rs189991563       rs190743758       rs191098508       rs191562646       rs192132325       rs192354269       rs199514554       rs199579218       rs200581535       rs200969597       rs201150181       rs201706408       rs202008449       rs368859310       rs369412479       rs370802051       rs372171070       rs372183197       rs372515234       rs373260820       rs373298182       rs373309667       rs373660644       rs374876678       rs375589560       rs375834623       rs376974878       rs377054180       rs377558637       rs527837408       rs527917782       rs528251296       rs528329212       rs528510211       rs529036881       rs529247271       rs529855408       rs530150336       rs530811324       rs531006039       rs531459585       rs531771821       rs531936529       rs532021059       rs532276883       rs532919179       rs533601769       rs533846497       rs534894684       rs535208721       rs535246550       rs536047250       rs536247580       rs536445057       rs536964359       rs537238041       rs537319507       rs538348855       rs538476059       rs538561928       rs539065995       rs540695176       rs541123476       rs541882343       rs541965749       rs543117630       rs543192940       rs543384494       rs544576964       rs544796683       rs545715854       rs545893576       rs546665002       rs547034446       rs547536465       rs547615326       rs548507577       rs548849329       rs549347014       rs549434148       rs550735926       rs551221381       rs552066454       rs552380815       rs552489183       rs553065290       rs553311570       rs553573065       rs553609722       rs553781758       rs554542634       rs555613374       rs556227666       rs556332429       rs556644658       rs557014006       rs557050891       rs558119181       rs558778966       rs559177656       rs560674342       rs560762158       rs561955467       rs562165886       rs563203122       rs563385804       rs563423661       rs564276814       rs564636896       rs564666086       rs565198357       rs565947524       rs566032455       rs566068510       rs566556646       rs566979130       rs567042194       rs567348306       rs567865956       rs568607117       rs568959017       rs569068334       rs569717795       rs569833162       rs570633794       rs570754792       rs570884296       rs570920774       rs571751431       rs571914609       rs572981380       rs573032909       rs573544796       rs573795078       rs574056302       rs574411567       rs574425420       rs574598851       rs575361229       rs576314735       rs576550945       rs577463916       rs577503071       rs745471377       rs745540785       rs745735992       rs745824050       rs745984085       rs746420274       rs746598589       rs747144219       rs747491535       rs748258858       rs748431546       rs748490190       rs748578329       rs749432078       rs749923821       rs749963792       rs750640400       rs750840300       rs750870565       rs751040168       rs751451296       rs751573030       rs751863307       rs751927402       rs752555928       rs752580629       rs752697751       rs753490012       rs753730764       rs754089115       rs754403710       rs754690446       rs754804430       rs754840151       rs754855270       rs755487430       rs755729396       rs755773799       rs756754655       rs757071365       rs757158654       rs757678737       rs757761235       rs758318134       rs758338208       rs758535976       rs758649526       rs758741179       rs758794256       rs759698795       rs759800041       rs759954368       rs760140099       rs760349365       rs760682674       rs760883576       rs760971779       rs761064355       rs761809165       rs762026765       rs762683331       rs762778690       rs763188625       rs763365891       rs763425001       rs763910005       rs764069360       rs764671012       rs764721527       rs765024136       rs765162616       rs765435662       rs765528807       rs765761966       rs765929030       rs766016242       rs766678124       rs766988755       rs767409909       rs767644132       rs767740445       rs768384322       rs769015314       rs769020735       rs769818192       rs769839504       rs769974877       rs770637509       rs770960308       rs770994134       rs771058284       rs771224470       rs771530778       rs771690252       rs772681644       rs772769296       rs772889204       rs773071580       rs773410182       rs773609684       rs773894662       rs774141032       rs774178766       rs774883248       rs774959099       rs775073017       rs775244532       rs775651591       rs775705851       rs776585836       rs776670653       rs776982277       rs777262002       rs777286638       rs777424828       rs778214957       rs778302663       rs778604094       rs779039644       rs779412432       rs779517966       rs779644262       rs779900257       rs779946635       rs780124333       rs780592378       rs781149929       rs781177812       rs781320035       rs781591110      

基因表达

基因表达

SOST基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GCTGGAGAACAACAAGACC
59
TACTCGGACACGTCTTTGG
60
AGAACAACAAGACCATGAACC
59
TACTCGGACACGTCTTTGG
60
GAGAACAACAAGACCATGAACC
60
TACTCGGACACGTCTTTGG
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

SOST基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

SOST基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0001503
Q9BQB4(UniProtKB)
IEA
GO:0005515
Q9BQB4(UniProtKB)
IPI
GO:0005515
Q9BQB4(UniProtKB)
IPI
GO:0005515
Q9BQB4(UniProtKB)
IPI
GO:0005515
Q9BQB4(UniProtKB)
IPI
GO:0005515
Q9BQB4(UniProtKB)
IPI
GO:0005515
Q9BQB4(UniProtKB)
IPI
GO:0005515
Q9BQB4(UniProtKB)
IPI
GO:0005515
Q9BQB4(UniProtKB)
IPI
GO:0005576
Q9BQB4(UniProtKB)
TAS
GO:0005578
Q9BQB4(UniProtKB)
IEA
GO:0005615
Q9BQB4(UniProtKB)
IEA
GO:0005794
Q9BQB4(UniProtKB)
IEA
GO:0008134
Q9BQB4(UniProtKB)
IDA
GO:0008201
Q9BQB4(UniProtKB)
IEA
GO:0009612
Q9BQB4(UniProtKB)
IEP
GO:0016055
Q9BQB4(UniProtKB)
IEA
GO:0030279
Q9BQB4(UniProtKB)
NAS
GO:0030279
Q9BQB4(UniProtKB)
NAS
GO:0030514
Q9BQB4(UniProtKB)
IDA
GO:0031333
Q9BQB4(UniProtKB)
IDA
GO:0045893
Q9BQB4(UniProtKB)
IMP
GO:0071374
Q9BQB4(UniProtKB)
IDA
GO:0090090
Q9BQB4(UniProtKB)
IDA
GO:0090090
Q9BQB4(UniProtKB)
TAS
GO:2000054
Q9BQB4(UniProtKB)
IDA
GO:0031012
Q9BQB4(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控SOST基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Sclerosteosis 0.563800186 14 3 BeFree_CLINVAR_CTD_human_MGD_ORPHANET_UNIPROT
CRANIODIAPHYSEAL DYSPLASIA, AUTOSOMAL DOMINANT (disorder) 0.240271442 1 1 BeFree_CLINVAR_UNIPROT
Craniodiaphyseal dysplasia 0.120271442 1 0 BeFree_ORPHANET
Osteochondrodysplasias 0.12 0 0 CTD_human
Van Buchem disease 0.08434307 16 0 BeFree_MGD
Osteoporosis 0.016349983 16 0 BeFree_GAD_LHGDN
Bone Diseases 0.00408156 5 0 BeFree_LHGDN
Degenerative polyarthritis 0.003181358 4 0 BeFree_GAD
Prostatic Neoplasms 0.00272435 1 0 LHGDN
Osteoarthritis, Knee 0.002638474 2 0 BeFree_GAD
Osteoarthritis of hip 0.002367032 1 0 GAD
Bone Diseases, Developmental 0.001628651 6 0 BeFree
Hyperostosis 0.001628651 6 0 BeFree
Osteosarcoma 0.000542884 2 0 BeFree
Syndactyly 0.000542884 2 0 BeFree
Osteosarcoma of bone 0.000542884 2 0 BeFree
OVERLAP CONNECTIVE TISSUE DISEASE 0.000542884 2 0 BeFree
Congenital Abnormality 0.000271442 1 0 BeFree
Diabetes 0.000271442 1 0 BeFree
Diabetes Mellitus 0.000271442 1 0 BeFree
Multiple Myeloma 0.000271442 1 0 BeFree
Osteitis Deformans 0.000271442 1 0 BeFree
Osteopetrosis 0.000271442 1 0 BeFree
Intervertebral Disc Degeneration 0.000271442 1 0 BeFree
Tumor Progression 0.000271442 1 0 BeFree
Squamous cell carcinoma of esophagus 0.000271442 1 0 BeFree
Worth disease 0.000271442 1 0 BeFree
Spondylarthritis 0.000271442 1 0 BeFree
Osteoarthritis, Spine 0.000271442 1 0 BeFree

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