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The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
[中文简述(自动翻译):]  由该基因编码的蛋白质属于酰基转移酶家族。它位于内质网,并催化脂肪酸胆固醇酯的形成。该基因已通过控制游离胆固醇和胞质胆甾醇酯之间的平衡中的β-淀粉样蛋白和动脉粥样硬化斑块的形成有关。另外剪接转录变体也发现了这种基因。 [由RefSeq的,2011年11月提供]
SOAT1基因(以及对应的蛋白质)的细胞分布位置:
SOAT1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Alzheimer's Disease | 0.010096888 | 4 | 0 | BeFree_GAD_LHGDN |
| Carcinogenesis | 0.004885954 | 18 | 0 | BeFree |
| Hyperlipidemia | 0.002909916 | 3 | 0 | BeFree_GAD |
| Anoxia | 0.00272435 | 1 | 0 | LHGDN |
| Renal Cell Carcinoma | 0.00272435 | 1 | 0 | LHGDN |
| Malignant neoplasm of breast | 0.002442977 | 9 | 0 | BeFree |
| Breast Carcinoma | 0.002442977 | 9 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.002171535 | 8 | 0 | BeFree |
| Myeloproliferative disease | 0.002171535 | 8 | 3 | BeFree |
| leukemia | 0.001900093 | 7 | 0 | BeFree |
| Lymphoma | 0.001900093 | 7 | 0 | BeFree |
| Liver carcinoma | 0.001900093 | 7 | 0 | BeFree |
| Arteriosclerosis | 0.001628651 | 6 | 0 | BeFree |
| Atherosclerosis | 0.001628651 | 6 | 0 | BeFree |
| HIV Infections | 0.001628651 | 6 | 0 | BeFree |
| Prostate carcinoma | 0.001628651 | 6 | 0 | BeFree |
| Rheumatoid Arthritis | 0.001357209 | 5 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.001357209 | 5 | 0 | BeFree |
| Adult T-Cell Lymphoma/Leukemia | 0.001085767 | 4 | 0 | BeFree |
| melanoma | 0.001085767 | 4 | 0 | BeFree |
| Multiple Myeloma | 0.001085767 | 4 | 0 | BeFree |
| Tumor Progression | 0.001085767 | 4 | 0 | BeFree |
| Carcinoma of lung | 0.001085767 | 4 | 0 | BeFree |
| Chronic myeloproliferative disorder | 0.001085767 | 4 | 0 | BeFree |
| Hepatocarcinogenesis | 0.001085767 | 4 | 0 | BeFree |
| Ataxia Telangiectasia | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of endometrium | 0.000814326 | 3 | 0 | BeFree |
| Hepatitis C | 0.000814326 | 3 | 0 | BeFree |
| Hodgkin Disease | 0.000814326 | 3 | 0 | BeFree |
| Myeloid Leukemia, Chronic | 0.000814326 | 3 | 0 | BeFree |
| Liver neoplasms | 0.000814326 | 3 | 0 | BeFree |
| Thrombocythemia, Essential | 0.000814326 | 3 | 0 | BeFree |
| Diffuse Large B-Cell Lymphoma | 0.000814326 | 3 | 0 | BeFree |
| Medullary carcinoma of thyroid | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000814326 | 3 | 0 | BeFree |
| Endometrial Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Leukemogenesis | 0.000814326 | 3 | 0 | BeFree |
| Uterine Corpus Cancer | 0.000814326 | 3 | 0 | BeFree |
| Brain Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Malignant tumor of colon | 0.000542884 | 2 | 0 | BeFree |
| Squamous cell carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant tumor of cervix | 0.000542884 | 2 | 0 | BeFree |
| Crohn Disease | 0.000542884 | 2 | 0 | BeFree |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.000542884 | 2 | 0 | BeFree |
| Down Syndrome | 0.000542884 | 2 | 0 | BeFree |
| Glioblastoma | 0.000542884 | 2 | 0 | BeFree |
| Hematological Disease | 0.000542884 | 2 | 0 | BeFree |
| Acute lymphocytic leukemia | 0.000542884 | 2 | 0 | BeFree |
| Leukemia, Lymphocytic, Acute, L1 | 0.000542884 | 2 | 0 | BeFree |
| Acute Promyelocytic Leukemia | 0.000542884 | 2 | 0 | BeFree |
| Leukemia, T-Cell | 0.000542884 | 2 | 0 | BeFree |
| Plasmacytoma | 0.000542884 | 2 | 0 | BeFree |
| Polycythemia Vera | 0.000542884 | 2 | 0 | BeFree |
| B-Cell Lymphomas | 0.000542884 | 2 | 0 | BeFree |
| Severe Combined Immunodeficiency | 0.000542884 | 2 | 0 | BeFree |
| Acute leukemia | 0.000542884 | 2 | 0 | BeFree |
| Fibrosis, Liver | 0.000542884 | 2 | 0 | BeFree |
| Cancer of Head and Neck | 0.000542884 | 2 | 0 | BeFree |
| Cervix carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000542884 | 2 | 0 | BeFree |
| Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.000542884 | 2 | 0 | BeFree |
| Leukemia, Large Granular Lymphocytic | 0.000542884 | 2 | 0 | BeFree |
| Nasopharyngeal carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Triple Negative Breast Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Primary Myelofibrosis | 0.000271442 | 1 | 0 | BeFree |
| Anemia | 0.000271442 | 1 | 0 | BeFree |
| Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Autistic Disorder | 0.000271442 | 1 | 0 | BeFree |
| Autoimmune Diseases | 0.000271442 | 1 | 0 | BeFree |
| Behcet Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Bone Diseases | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cardiovascular Diseases | 0.000271442 | 1 | 0 | BeFree |
| Cerebral Infarction | 0.000271442 | 1 | 0 | BeFree |
| Delirium | 0.000271442 | 1 | 0 | BeFree |
| Diabetes | 0.000271442 | 1 | 0 | BeFree |
| Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
| Dry Eye Syndromes | 0.000271442 | 1 | 0 | BeFree |
| Fanconi Anemia | 0.000271442 | 1 | 0 | BeFree |
| Giardiasis | 0.000271442 | 1 | 0 | BeFree |
| Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
| Immune System Diseases | 0.000271442 | 1 | 0 | BeFree |
| Influenza | 0.000271442 | 1 | 0 | BeFree |
| Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
| Leishmaniasis | 0.000271442 | 1 | 0 | BeFree |
| Myeloid Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Chronic Neutrophilic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Leukoencephalopathy, Progressive Multifocal | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma, Non-Hodgkin | 0.000271442 | 1 | 0 | BeFree |
| Meningioma | 0.000271442 | 1 | 0 | BeFree |
| Myelofibrosis | 0.000271442 | 1 | 0 | BeFree |
| Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
| Nephroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Polycythemia | 0.000271442 | 1 | 0 | BeFree |
| Psoriasis | 0.000271442 | 1 | 0 | BeFree |
| Rabies (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Rheumatic Heart Disease | 0.000271442 | 1 | 0 | BeFree |
| Sarcoidosis | 0.000271442 | 1 | 0 | BeFree |
| Staphylococcal Infections | 0.000271442 | 1 | 0 | BeFree |
| Synovitis | 0.000271442 | 1 | 0 | BeFree |
| Vascular Diseases | 0.000271442 | 1 | 0 | BeFree |
| Xanthomatosis | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma, T-Cell, Cutaneous | 0.000271442 | 1 | 0 | BeFree |
| Pancreatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Epstein-Barr Virus Infections | 0.000271442 | 1 | 0 | BeFree |
| Primary Sj�gren's syndrome | 0.000271442 | 1 | 0 | BeFree |
| Porphyria Cutanea Tarda | 0.000271442 | 1 | 0 | BeFree |
| Hepatoblastoma | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Female Pseudohermaphroditism | 0.000271442 | 1 | 0 | BeFree |
| T-cell adult acute lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Gallbladder adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Solid tumour | 0.000271442 | 1 | 0 | BeFree |
| Dryness of eye | 0.000271442 | 1 | 0 | BeFree |
| Tumor necrosis | 0.000271442 | 1 | 0 | BeFree |
| Impaired cognition | 0.000271442 | 1 | 0 | BeFree |
| Glaucoma, Primary Open Angle | 0.000271442 | 1 | 0 | BeFree |
| Eosinophilic esophagitis | 0.000271442 | 1 | 0 | BeFree |
| Breast Cancer, Familial | 0.000271442 | 1 | 0 | BeFree |
| Juvenile Myelomonocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
| Primary immune deficiency disorder | 0.000271442 | 1 | 0 | BeFree |
| Peritoneal Fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant Glioma | 0.000271442 | 1 | 0 | BeFree |
| Tumor Initiation | 0.000271442 | 1 | 0 | BeFree |
| Mitochondrial Diseases | 0.000271442 | 1 | 0 | BeFree |
| STUVE-WIEDEMANN SYNDROME | 0.000271442 | 1 | 0 | BeFree |
| Rhabdoid Tumor of the Kidney | 0.000271442 | 1 | 0 | BeFree |
| Cerebral Ischemia | 0.000271442 | 1 | 0 | BeFree |
| Metastatic Prostate Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Classical Hodgkin's Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Epithelioma | 0.000271442 | 1 | 0 | BeFree |
| Erythrocytosis | 0.000271442 | 1 | 0 | BeFree |
| Deficiency of acetyl-CoA acetyltransferase | 0.000271442 | 1 | 0 | BeFree |
| Meningioma, benign, no ICD-O subtype | 0.000271442 | 1 | 0 | BeFree |
| Promyelocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
| FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Experimental Organism Basal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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