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This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码的剪接因子3b的蛋白复合物的亚单位2。剪接因子3B,与剪接因子3a和12S RNA单元一起,构成复杂U2小核核糖(U2核蛋白)。剪接因子3b中/ 3A复合物结合mRNA前体中的序列无关的方式的内含子的分支点的上游,并且可以锚U2核蛋白的前mRNA。剪接因子3b是也轻微U12型剪接的组分。亚基2同伙与mRNA前体在锚固部位分支站点的上游。亚基2还直接与剪接因子3b的复杂的亚基4相互作用。亚基2是具有一个富含脯氨酸的N-末端和在C末端的富含谷氨酸 - 拉伸高度亲水蛋白质。 [由RefSeq的,2008年7月提供]
SF3B2基因(以及对应的蛋白质)的细胞分布位置:
SF3B2基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Chronic Lymphocytic Leukemia | 0.006514605 | 24 | 0 | BeFree |
| Preleukemia | 0.002714419 | 10 | 0 | BeFree |
| Uveal melanoma | 0.002442977 | 9 | 0 | BeFree |
| Refractory anemias | 0.002171535 | 8 | 2 | BeFree |
| Refractory anemia, without ringed sideroblasts, without excess blasts | 0.002171535 | 8 | 2 | BeFree |
| MYELODYSPLASTIC SYNDROME | 0.001628651 | 6 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.001085767 | 4 | 0 | BeFree |
| Leukemia, Myelomonocytic, Chronic | 0.001085767 | 4 | 0 | BeFree |
| melanoma | 0.001085767 | 4 | 0 | BeFree |
| Myelodysplasia | 0.001085767 | 4 | 0 | BeFree |
| Thrombocytosis | 0.000814326 | 3 | 2 | BeFree |
| Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
| Cutaneous Melanoma | 0.000542884 | 2 | 0 | BeFree |
| Myelodysplastic-Myeloproliferative Diseases | 0.000542884 | 2 | 0 | BeFree |
| Refractory anemia with excess blasts I | 0.000542884 | 2 | 0 | BeFree |
| RETINOSCHISIS 1, X-LINKED, JUVENILE | 0.000542884 | 2 | 0 | BeFree |
| Anemia, Macrocytic | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Mucinous Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Congenital chromosomal disease | 0.000271442 | 1 | 0 | BeFree |
| Heart Diseases | 0.000271442 | 1 | 0 | BeFree |
| Lymphocytosis | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Monosomy | 0.000271442 | 1 | 0 | BeFree |
| Chronic lymphocytic leukaemia refractory | 0.000271442 | 1 | 0 | BeFree |
| Cancer of Head and Neck | 0.000271442 | 1 | 0 | BeFree |
| Iron Overload | 0.000271442 | 1 | 0 | BeFree |
| Richter's syndrome | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
| Hematopoietic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Hematologic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
| Progressive Neoplastic Disease | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Chromosome 12, 12p trisomy | 0.000271442 | 1 | 0 | BeFree |
| myocardial hypoxia | 0.000271442 | 1 | 0 | BeFree |
| Refractory anemia with ringed sideroblasts | 0.000271442 | 1 | 0 | BeFree |
| Progressive cGVHD | 0.000271442 | 1 | 0 | BeFree |
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