更多...
收起
The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]
[中文简述(自动翻译):]  由该基因编码的蛋白质是几个钠通道β亚基之一。这些亚基与电压门控α亚相互作用改变钠通道动力学。所编码的跨膜蛋白形式间二硫键与SCN2A。这种基因缺陷是长QT综合征类型10(LQT10)的原因。三蛋白质编码和一个非编码转录变异也发现了这种基因。[由RefSeq的,2009年03月提供]
SCN4B基因(以及对应的蛋白质)的细胞分布位置:
SCN4B基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Long Qt Syndrome 10 | 0.36 | 2 | 1 | CLINVAR_CTD_human_UNIPROT |
| Romano-Ward Syndrome | 0.12 | 0 | 0 | ORPHANET |
| Sudden infant death syndrome | 0.12 | 0 | 1 | CLINVAR |
| Long QT Syndrome | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Atrial Fibrillation | 0.002367032 | 1 | 0 | GAD |
| Congenital long QT syndrome | 0.000271442 | 1 | 1 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。