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Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  核糖体,催化合成蛋白质复合物,由一个小40S亚基和60S大亚基。一起这些亚基组成的4 RNA种类和大约80结构不同的蛋白质。该基因编码一种核糖体蛋白,它是60S亚基的一个组成部分。该蛋白属于L3P家族核糖体蛋白,它是位于细胞质中。蛋白质可以结合到HIV-1的TAR的mRNA,并且它已经表明该蛋白质有助于达介导的反式激活。该基因共同转录与几个核仁小分子RNA基因,分别位于几个这种基因的内含子。备用转录剪接变体,编码不同同种型,已经表征。作为典型编码核糖体蛋白的基因,有该基因通过基因组分散的多个经处理的假基因。 [由RefSeq的,2008年7月提供]
RPL3基因(以及对应的蛋白质)的细胞分布位置:
RPL3基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Animal Mammary Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Mammary Neoplasms, Experimental | 0.12 | 1 | 0 | CTD_human |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Down Syndrome | 0.000271442 | 1 | 0 | BeFree |
| melanoma | 0.000271442 | 1 | 0 | BeFree |
| Mycoses | 0.000271442 | 1 | 0 | BeFree |
| Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
| Chagas Disease | 0.000271442 | 1 | 0 | BeFree |
| Tuberculosis | 0.000271442 | 1 | 0 | BeFree |
| Myopathies, Nemaline | 0.000271442 | 1 | 0 | BeFree |
| Gastrointestinal Stromal Tumors | 0.000271442 | 1 | 0 | BeFree |
| Q fever endocarditis | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| NIEMANN-PICK DISEASE, TYPE C2 | 0.000271442 | 1 | 0 | BeFree |
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