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This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]
[中文简述(自动翻译):]  这个基因编码转录阻遏该压制神经元基因非神经组织。它是Kruppel型锌指转录因子家族的一个成员。它通过结合被称为神经元限制性消声元件的DNA序列元件压制转录。该蛋白质是在未分化的神经元祖细胞也发现,它被认为是此阻遏可作为神经发生的一个主负定期采取行动。另外剪接转录变体已被描述[按RefSeq的,2010年7月提供]
REST基因(以及对应的蛋白质)的细胞分布位置:
REST基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Age related macular degeneration | 0.122638474 | 2 | 2 | BeFree_GAD_GWASCAT |
| Nephroblastoma | 0.12 | 1 | 0 | CTD_human |
| Seizures | 0.12 | 1 | 0 | CTD_human |
| Medulloblastoma | 0.007620235 | 8 | 0 | BeFree_LHGDN |
| Down Syndrome | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Mental Retardation, X-Linked | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Neuroblastoma | 0.001900093 | 7 | 0 | BeFree |
| Central neuroblastoma | 0.001628651 | 6 | 0 | BeFree |
| Malignant neoplasm of breast | 0.001357209 | 5 | 0 | BeFree |
| Glioma | 0.001357209 | 5 | 0 | BeFree |
| Huntington Disease | 0.001357209 | 5 | 0 | BeFree |
| Cerebrovascular accident | 0.001357209 | 5 | 0 | BeFree |
| Small cell carcinoma of lung | 0.001357209 | 5 | 0 | BeFree |
| Carcinogenesis | 0.001357209 | 5 | 0 | BeFree |
| Neurodegenerative Disorders | 0.001085767 | 4 | 0 | BeFree |
| Breast Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Glioblastoma | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000814326 | 3 | 0 | BeFree |
| Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Cerebral Infarction | 0.000542884 | 2 | 0 | BeFree |
| Heart Diseases | 0.000542884 | 2 | 0 | BeFree |
| Ischemia | 0.000542884 | 2 | 0 | BeFree |
| melanoma | 0.000542884 | 2 | 0 | BeFree |
| nervous system disorder | 0.000542884 | 2 | 0 | BeFree |
| Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Teratocarcinoma | 0.000542884 | 2 | 0 | BeFree |
| Cerebral Ischemia | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
| Alzheimer's Disease | 0.000271442 | 1 | 0 | BeFree |
| Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cardiomyopathy, Dilated | 0.000271442 | 1 | 0 | BeFree |
| Cerebellar Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Brain Ischemia | 0.000271442 | 1 | 0 | BeFree |
| Epilepsy | 0.000271442 | 1 | 0 | BeFree |
| Fragile X Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Hodgkin Disease | 0.000271442 | 1 | 0 | BeFree |
| Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
| Nervous System Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| oligodendroglioma | 0.000271442 | 1 | 0 | BeFree |
| Unipolar Depression | 0.000271442 | 1 | 0 | BeFree |
| Agitation | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of mouth | 0.000271442 | 1 | 0 | BeFree |
| Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
| Lip and Oral Cavity Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Anaplastic Oligodendroglioma | 0.000271442 | 1 | 0 | BeFree |
| Ewings sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Well Differentiated Oligodendroglioma | 0.000271442 | 1 | 0 | BeFree |
| latent infection | 0.000271442 | 1 | 0 | BeFree |
| Ischemic stroke | 0.000271442 | 1 | 0 | BeFree |
| Major Depressive Disorder | 0.000271442 | 1 | 0 | BeFree |
| Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
| MYOTILINOPATHY | 0.000271442 | 1 | 0 | BeFree |
| INTELLIGENCE QUANTITATIVE TRAIT LOCUS 1 | 0.000271442 | 1 | 0 | BeFree |
| Ischemic Cerebrovascular Accident | 0.000271442 | 1 | 0 | BeFree |
| Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
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