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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是蛋白质酪氨酸磷酸酶(PTP)家族的一个成员。的PTPs已知是信令调节多种细胞过程,包括细胞生长,分化,有丝分裂周期,和致癌性转化的分子。此PTP包含的胞外区,一个跨膜片段和两个串联胞质内催化域,并因此代表了受体型PTP。这种蛋白的胞外区是由多个样Ig和纤连蛋白III型样结构域的。在小鼠中相似的基因的研究表明,这PTP可在细胞 - 细胞相互作用,初级axonogenesis和轴突导向胚胎发育过程中的参与。这PTP也已牵涉到成年神经修复的分子控制。四可变剪接转录物变体,其编码不同的蛋白质,已经报道了。 [由RefSeq的,2008年7月提供]
PTPRS基因(以及对应的蛋白质)的细胞分布位置:
PTPRS基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.005091382 | 1 | 0 | GAD_LHGDN |
| Ulcerative Colitis | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Neoplastic Cell Transformation | 0.002367032 | 1 | 0 | GAD |
| Colorectal Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Microsatellite Instability | 0.002367032 | 1 | 0 | GAD |
| Congenital chromosomal disease | 0.000271442 | 1 | 0 | BeFree |
| Colitis | 0.000271442 | 1 | 0 | BeFree |
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