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This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. [provided by RefSeq, Aug 2011]
[中文简述(自动翻译):]  该基因编码定位于点状发生接近拼接斑点,被称为paraspeckles亚核结构的核仁蛋白。这些paraspeckles是由包含非编码RNA,利落/男性小量/β和蛋白质的果蝇行为人剪接家族,其包括本基因和P54NRB / NONO和PSF / SFPQ的产物RNA的蛋白质结构的蛋白质。 Paraspeckles可以通过一种RNA核保留机制的基因表达的控制作用。由该基因编码的蛋白质在转录活性细胞paraspeckles被发现,但它在核仁周边定位于独特帽结构时RNA聚合酶II的转录被抑制,或末期期间。这个基因的选择性剪接的结果在多个转录变体。一个相关的假基因,也位于13号染色体上,已被确定。 [由RefSeq的,2011年8月提供]
PSPC1基因(以及对应的蛋白质)的细胞分布位置:
PSPC1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Progressive supranuclear palsy | 0.000271442 | 1 | 0 | BeFree |
| Neurofibrillary degeneration (morphologic abnormality) | 0.000271442 | 1 | 0 | BeFree |
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