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This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
[中文简述(自动翻译):]  该基因编码的蛋白磷酸酶的恒定调节亚基2.蛋白质磷酸酶2是四大丝氨酸/苏氨酸磷酸酶的之一,它是在细胞生长和分裂的阴性对照牵连。它由一个共同的异核心酶,它是由一个催化亚基和一个常数调节亚基,即相关联的各种调节亚基组成。常数调节亚基一个用作脚手架分子坐标催化亚基和可变调节B亚单位的组装。该基因编码的常数调节亚基A.备选剪接转录变体已经描述的α-同种型。 [由RefSeq的,2010年4月提供]
PPP2R1A基因(以及对应的蛋白质)的细胞分布位置:
PPP2R1A基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Degenerative polyarthritis | 0.12 | 1 | 0 | CTD_human |
Stomach Neoplasms | 0.12 | 1 | 0 | CTD_human |
Disease Progression | 0.12 | 1 | 0 | CTD_human |
Malignant neoplasm of breast | 0.002638474 | 1 | 0 | BeFree_GAD |
Ovarian Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Carcinoma, Endometrioid | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of endometrium | 0.000542884 | 2 | 0 | BeFree |
Cystadenocarcinoma, Serous | 0.000542884 | 2 | 0 | BeFree |
Endometrial Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Uterine Corpus Cancer | 0.000542884 | 2 | 0 | BeFree |
Mucinous Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinosarcoma | 0.000271442 | 1 | 0 | BeFree |
Heart failure | 0.000271442 | 1 | 0 | BeFree |
Congestive heart failure | 0.000271442 | 1 | 0 | BeFree |
Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Nephroblastoma | 0.000271442 | 1 | 0 | BeFree |
Uterine Cancer | 0.000271442 | 1 | 0 | BeFree |
Undifferentiated carcinoma | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma, Clear Cell | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
hereditary Wilms' tumor (WT1) | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
ovarian neoplasm | 0.000271442 | 1 | 0 | BeFree |
Metastatic Prostate Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Breast Fibrocystic Change, Proliferative Type | 0.000271442 | 1 | 0 | BeFree |
Hepatocarcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
High grade serous carcinoma | 0.000271442 | 1 | 0 | BeFree |
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