PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha)

基因基本信息

基因基本信息

symbol:
PPP2R1A
locus group:
protein-coding gene
location:
19q13.41
gene_family:
Protein phosphatase 2 regulatory subunits
alias symbol:
PR65A|PP2A-Aalpha|PP2AA
alias name:
protein phosphatase 2A, regulatory…
entrez id:
5518
ensembl gene id:
ENSG00000105568
ucsc gene id:
uc002pyp.4
refseq accession:
NM_014225
hgnc_id:
HGNC:9302
approved reserved:
1993-01-25

基因染色体位置

基因染色体位置

19q13.41
基因染色体位置图

基因简述

基因简述

PPP2R1A是蛋白磷酸酶2A（PP2A）的一个调节亚基，属于PPP2R1基因家族。PP2A是一种重要的丝氨酸/苏氨酸蛋白磷酸酶，参与多种细胞过程，包括细胞周期调控、信号转导、代谢和凋亡。PPP2R1A编码的Aα亚基是PP2A全酶的核心支架结构，负责连接催化亚基（C亚基）和调节亚基（B亚基），从而形成具有不同底物特异性和功能的PP2A全酶复合物。PPP2R1A在维持细胞稳态中起关键作用，其突变或表达异常与多种疾病相关，尤其是癌症。例如，PPP2R1A的某些突变（如E64D、R183W）会导致PP2A功能丧失，进而促进细胞增殖和肿瘤发生，这些突变在子宫内膜癌、卵巢癌和肺癌中较为常见。PPP2R1A的过表达可能增强PP2A的抑癌功能，抑制肿瘤生长，而降低表达则可能导致PP2A活性下降，增加细胞异常增殖的风险。此外，PPP2R1A还参与调控Wnt、MAPK和PI3K/AKT等信号通路，影响细胞分化、迁移和存活。PPP2R1基因家族包括PPP2R1A和PPP2R1B，两者编码的Aα和Aβ亚基结构相似，但在组织和发育阶段的表达模式不同。PPP2R1A突变还与神经发育障碍和心血管疾病有关，突显其在多种生理和病理过程中的重要性。

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

该基因编码的蛋白磷酸酶的恒定调节亚基2.蛋白质磷酸酶2是四大丝氨酸/苏氨酸磷酸酶的之一，它是在细胞生长和分裂的阴性对照牵连。它由一个共同的异核心酶，它是由一个催化亚基和一个常数调节亚基，即相关联的各种调节亚基组成。常数调节亚基一个用作脚手架分子坐标催化亚基和可变调节B亚单位的组装。该基因编码的常数调节亚基A.备选剪接转录变体已经描述的α-同种型。 [由RefSeq的，2010年4月提供]

OMIM数据库中对PPP2R1A基因的介绍     Wikipedia数据库中对PPP2R1A基因的介绍

基因序列

基因序列

PPP2R1A基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

PPP2R1A基因的碱基突变：           仅显示部分snp
rs2162779       rs10413435       rs10414852       rs41275802       rs41275804       rs80257415       rs111484780       rs111741898       rs112316360       rs112479469       rs112586735       rs113187868       rs113447231       rs137872459       rs138066943       rs149542408       rs186098387      

基因表达

基因表达

PPP2R1A基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TGCCTTTCCTTACAGATACCA
59
AGGGTAGTGAAGGTTCCCA
60
TGCCTTTCCTTACAGATACCA
59
AGGGTAGTGAAGGTTCCCA
60
AAGCCCATCCTAGAGAAGC
59
AGAGACAGAACAGTCAGAGC
59
ATGAGGACGTTCAGAGACG
59
TAATTCCAACACTTTGGGAGG
58
AAGCCCATCCTAGAGAAGC
59
AGAGACAGAACAGTCAGAGC
59
GGACAACGTCAAGAGTGAG
58
ACTGCTTTCTGGAGCTCTG
60
GAGATCACCAAGACAGACCT
59
CACAGAACTCTTTGACCTTGTG
60
TCTGCATCAATGTGCTGTC
59
ACATTGAAGCGGACATTGG
59
TGCCTTTCCTTACAGATACCA
59
AGGGTAGTGAAGGTTCCCA
60
TGCCTTTCCTTACAGATACCA
59
AGGGTAGTGAAGGTTCCCA
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

PPP2R1A基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

PPP2R1A基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0006461
B3KQV6 (UniProtKB)
IEA
GO:0008601
B3KQV6 (UniProtKB)
IEA
GO:0034047
B3KQV6 (UniProtKB)
IEA
GO:0006461
C9J9C1 (UniProtKB)
IEA
GO:0008601
C9J9C1 (UniProtKB)
IEA
GO:0034047
C9J9C1 (UniProtKB)
IEA
GO:0000086
P30153 (UniProtKB)
TAS
GO:0000159
P30153 (UniProtKB)
TAS
GO:0000159
P30153 (UniProtKB)
IDA
GO:0000159
P30153 (UniProtKB)
IDA
GO:0000184
P30153 (UniProtKB)
TAS
GO:0000188
P30153 (UniProtKB)
NAS
GO:0000775
P30153 (UniProtKB)
IDA
GO:0003823
P30153 (UniProtKB)
IPI
GO:0003823
P30153 (UniProtKB)
IPI
GO:0004722
P30153 (UniProtKB)
IEA
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005515
P30153 (UniProtKB)
IPI
GO:0005634
P30153 (UniProtKB)
NAS
GO:0005739
P30153 (UniProtKB)
NAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0005829
P30153 (UniProtKB)
TAS
GO:0006275
P30153 (UniProtKB)
NAS
GO:0006355
P30153 (UniProtKB)
NAS
GO:0006461
P30153 (UniProtKB)
TAS
GO:0006470
P30153 (UniProtKB)
TAS
GO:0006672
P30153 (UniProtKB)
NAS
GO:0006915
P30153 (UniProtKB)
TAS
GO:0007059
P30153 (UniProtKB)
IDA
GO:0007084
P30153 (UniProtKB)
TAS
GO:0007143
P30153 (UniProtKB)
IEA
GO:0008380
P30153 (UniProtKB)
NAS
GO:0008601
P30153 (UniProtKB)
TAS
GO:0010033
P30153 (UniProtKB)
NAS
GO:0015630
P30153 (UniProtKB)
NAS
GO:0016020
P30153 (UniProtKB)
NAS
GO:0019932
P30153 (UniProtKB)
NAS
GO:0030111
P30153 (UniProtKB)
NAS
GO:0030155
P30153 (UniProtKB)
NAS
GO:0030308
P30153 (UniProtKB)
NAS
GO:0034047
P30153 (UniProtKB)
IEA
GO:0040008
P30153 (UniProtKB)
NAS
GO:0042518
P30153 (UniProtKB)
NAS
GO:0045595
P30153 (UniProtKB)
NAS
GO:0046982
P30153 (UniProtKB)
IPI
GO:0051232
P30153 (UniProtKB)
IEA
GO:0051306
P30153 (UniProtKB)
IEA
GO:0051754
P30153 (UniProtKB)
IEA
GO:0070062
P30153 (UniProtKB)
IDA
GO:0070262
P30153 (UniProtKB)
IEA
GO:1903538
P30153 (UniProtKB)
IEA
GO:2001241
P30153 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 PPP2R1A基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Degenerative polyarthritis 0.12 1 0 CTD_human
Disease Progression 0.12 1 0 CTD_human
Stomach Neoplasms 0.12 1 0 CTD_human
Malignant neoplasm of breast 0.002638474 1 0 BeFree_GAD
Ovarian Carcinoma 0.001357209 5 0 BeFree
Malignant neoplasm of ovary 0.000814326 3 0 BeFree
Carcinoma, Endometrioid 0.000814326 3 0 BeFree
Malignant neoplasm of endometrium 0.000542884 2 0 BeFree
Endometrial Carcinoma 0.000542884 2 0 BeFree
Uterine Corpus Cancer 0.000542884 2 0 BeFree

基因相关服务

基因相关服务

联系方式

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