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Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010 [PubMed 20813920]).[supplied by OMIM, Nov 2010]
[中文简述(自动翻译):]  压电的各种物种间保守的大跨膜蛋白,所有24和36之间有预测跨膜结构域。 “压电”来自希腊语“piesi,”意义“的压力。”所述FAM38A基因编码PIEZO1,诱导机械活化的在各种细胞类型(马萨诸塞州)的电流的蛋白质(科斯特等人,2010 [搜索PubMed 20813920])。[由OMIM,2010年11月供给]
PIEZO1基因(以及对应的蛋白质)的细胞分布位置:
PIEZO1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Xerocytosis | 0.241357209 | 6 | 10 | BeFree_CLINVAR_UNIPROT |
Disease Progression | 0.00272435 | 1 | 0 | LHGDN |
Rheumatoid Arthritis | 0.000542884 | 2 | 0 | BeFree |
Dehydration | 0.000542884 | 2 | 0 | BeFree |
Atrial Septal Defects | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Colorectal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Small cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Cervical Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
Senile Plaques | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Rash and Dermatitis Adverse Event Associated with Chemoradiation | 0.000271442 | 1 | 0 | BeFree |
Alport Syndrome | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
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