PFN1(profilin 1) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

17p13.2
基因染色体位置图

基因简述

基因简述

This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]

[中文简述(自动翻译):]  该基因编码的profilin的家庭小肌动蛋白结合蛋白的成员。所编码的蛋白质起着通过响应于细胞外信号调节肌动蛋白聚合的肌动蛋白动力学具有重要作用。该基因的缺失与米勒 - Dieker综合征相关联，并且所编码的蛋白质也可起到在Huntington疾病的作用。该基因的多个假都位于1号染色体上[由RefSeq的，2012年7月提供]

OMIM数据库中对PFN1基因的介绍     Wikipedia数据库中对PFN1基因的介绍

基因序列

基因序列

PFN1基因的碱基序列：[NCBI]

基因突变

基因突变

PFN1基因的碱基突变：           显示全部snp
rs238241       rs1065632       rs1065633       rs2238534       rs2283568       rs4790714       rs11538685       rs11650919       rs16954289       rs16954291       rs73343371       rs76811485       rs79435236       rs112008527       rs112089924       rs113460962       rs113676037       rs113707551       rs115138905       rs117337116       rs140177490       rs141179182       rs144759293       rs146306590       rs148770753       rs149463580       rs150748026       rs183149554       rs183266762       rs183617200       rs187934385       rs189947255       rs191391924       rs199706330       rs199787307       rs200502153       rs201523968      
rs369165495       rs371298008       rs371362753       rs372372740       rs372941826       rs372994613       rs374939304       rs375374801       rs376068871       rs376236042       rs376748384       rs377242789       rs377701305       rs527463457       rs527589018       rs527928127       rs528614399       rs530473403       rs531122494       rs531564000       rs531584914       rs531984133       rs532583939       rs534109953       rs534528956       rs535948862       rs536627685       rs537482317       rs537951181       rs538088963       rs540160669       rs540862459       rs541078523       rs543159338       rs543265055       rs544376701       rs544516680       rs545918527       rs546259262       rs546409934       rs547348951       rs547684573       rs547700724       rs548247465       rs550153667       rs552142869       rs552278267       rs552289472       rs552338350       rs553343580       rs553365734       rs553477407       rs554136339       rs554497197       rs554750350       rs554870372       rs554889021       rs555482993       rs556200393       rs556863440       rs557065762       rs557401653       rs558605085       rs559112186       rs559783649       rs560095953       rs560570082       rs561754079       rs561826954       rs561888119       rs562443624       rs562547327       rs562614159       rs564201500       rs565553056       rs566561832       rs566708384       rs566876439       rs567697940       rs568361414       rs568459277       rs568653631       rs568870586       rs569004633       rs569094456       rs569704822       rs570979193       rs572034415       rs573280992       rs574036296       rs574781075       rs574888149       rs574967310       rs575408832       rs575465945       rs575490646       rs576081112       rs746908706       rs747267179       rs748155601       rs748285727       rs748386489       rs748461370       rs749407067       rs749566386       rs749885405       rs749940619       rs751079083       rs752550133       rs753054048       rs753485046       rs755612577       rs755758083       rs756255421       rs756406576       rs756423757       rs756919408       rs758863313       rs759484888       rs759611551       rs760016635       rs760599883       rs761461782       rs761974632       rs762660380       rs763837842       rs763937089       rs764748440       rs764829202       rs765279496       rs765861109       rs767404914       rs767562590       rs767938035       rs768591425       rs768710883       rs768871076       rs769624538       rs769909149       rs769919606       rs771133577       rs772423398       rs772582282       rs773220228       rs773355109       rs775379304       rs775540892       rs775892680       rs777507874       rs778007949       rs778122726       rs778354888       rs779195721       rs781405356       rs781559312       rs6559       rs13204       rs238242       rs238243       rs1804220       rs1859433       rs2233655       rs2233656       rs2233657       rs2233658       rs11538691       rs73343369       rs73973665       rs77350166       rs77750855       rs78068573       rs78224458       rs79843668       rs112009460       rs113150784       rs113497606       rs113941832       rs116049647       rs118186761       rs138146121       rs138201218       rs140057352       rs140547520       rs141382214       rs142426330       rs142691610       rs143584292       rs143858310       rs143906754       rs145109002       rs148930718       rs150230974       rs151313170       rs186959375       rs200264388       rs200415929       rs200446760       rs201226862       rs202232499       rs367732620       rs369356618       rs369839911       rs370738769       rs370958423       rs370983267       rs371230805       rs371270380       rs372205846       rs374173136       rs374390147       rs375761904       rs376281419       rs527646073       rs528614399       rs529161805       rs529473892       rs532953047       rs534031352       rs535018428       rs535481129       rs536157904       rs539349648       rs539631944       rs541066743       rs541085947       rs542393726       rs543102997       rs543229238       rs543946907       rs546700179       rs547907008       rs548819256       rs549731266       rs550064446       rs550290912       rs552022721       rs552760995       rs552898299       rs555410283       rs556065443       rs556606297       rs556846271       rs557425154       rs557936205       rs558780106       rs559719601       rs561769619       rs563419469       rs563647031       rs563754184       rs565692021       rs566416022       rs568073725       rs569207666       rs570221126       rs570282853       rs570839359       rs571042585       rs572020634       rs572159626       rs572943612       rs573535209       rs574172293       rs577082565       rs577984048       rs746405043       rs746824934       rs747690632       rs747850206       rs748864924       rs749215794       rs749741600       rs750830676       rs751261956       rs751605549       rs752047667       rs752390915       rs753464610       rs754367238       rs754796691       rs754987286       rs755290841       rs755885373       rs756166331       rs757148904       rs758578095       rs758743725       rs759969693       rs760127827       rs760956250       rs762351868       rs763553380       rs763710875       rs763847154       rs764145549       rs765843737       rs766371231       rs766671137       rs768368624       rs770373552       rs771709608       rs772921326       rs773831175       rs774544158       rs774832087       rs775028140       rs775040024       rs776213636       rs776338580       rs777086740       rs778615999       rs778846806       rs779455081       rs779656325       rs780168473       rs781012923       rs781369153      

基因表达

基因表达

PFN1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CATGGATCTTCGTACCAAGAG
58
AGGACTAGCGTCTTGTCAG
59
TAGCATGGATCTTCGTACCA
58
AGGACTAGCGTCTTGTCAG
59
AGCATGGATCTTCGTACCA
59
AGGACTAGCGTCTTGTCAG
59
TAGCATGGATCTTCGTACCA
58
AGGACTAGCGTCTTGTCAG
59
AACGTTCGTCAACATCACG
59
AAACTTGACCGGTCTTTGC
59
AGCATGGATCTTCGTACCA
59
AGGACTAGCGTCTTGTCAG
59
AACGTTCGTCAACATCACG
59
CAAGTGTCAGCCCATTCAC
59
AAACGTTCGTCAACATCACG
60
AAACTTGACCGGTCTTTGC
59
CATGGATCTTCGTACCAAGAG
58
AGGACTAGCGTCTTGTCAG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

PFN1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

PFN1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0003779
I3L3D5(UniProtKB)
IEA
GO:0030036
I3L3D5(UniProtKB)
IEA
GO:0003779
K7EJ44(UniProtKB)
IEA
GO:0030036
K7EJ44(UniProtKB)
IEA
GO:0000774
P07737(UniProtKB)
IDA
GO:0001843
P07737(UniProtKB)
IEA
GO:0003779
P07737(UniProtKB)
IPI
GO:0003779
P07737(UniProtKB)
IPI
GO:0003785
P07737(UniProtKB)
IDA
GO:0005102
P07737(UniProtKB)
IEA
GO:0005515
P07737(UniProtKB)
IPI
GO:0005515
P07737(UniProtKB)
IPI
GO:0005515
P07737(UniProtKB)
IPI
GO:0005515
P07737(UniProtKB)
IPI
GO:0005515
P07737(UniProtKB)
IPI
GO:0005515
P07737(UniProtKB)
IPI
GO:0005546
P07737(UniProtKB)
IDA
GO:0005634
P07737(UniProtKB)
IDA
GO:0005737
P07737(UniProtKB)
IDA
GO:0005829
P07737(UniProtKB)
TAS
GO:0005856
P07737(UniProtKB)
IEA
GO:0005925
P07737(UniProtKB)
IDA
GO:0005938
P07737(UniProtKB)
IDA
GO:0010634
P07737(UniProtKB)
IMP
GO:0016020
P07737(UniProtKB)
IDA
GO:0017048
P07737(UniProtKB)
IEA
GO:0030036
P07737(UniProtKB)
IEA
GO:0030837
P07737(UniProtKB)
IDA
GO:0030838
P07737(UniProtKB)
IGI
GO:0032232
P07737(UniProtKB)
IMP
GO:0032233
P07737(UniProtKB)
IBA
GO:0032781
P07737(UniProtKB)
IDA
GO:0043005
P07737(UniProtKB)
IEA
GO:0044822
P07737(UniProtKB)
IDA
GO:0045202
P07737(UniProtKB)
IEA
GO:0045944
P07737(UniProtKB)
IEA
GO:0050434
P07737(UniProtKB)
IEA
GO:0050821
P07737(UniProtKB)
IDA
GO:0051054
P07737(UniProtKB)
IEA
GO:0051496
P07737(UniProtKB)
IEA
GO:0051497
P07737(UniProtKB)
IMP
GO:0060071
P07737(UniProtKB)
TAS
GO:0070062
P07737(UniProtKB)
IDA
GO:0070062
P07737(UniProtKB)
IDA
GO:0070062
P07737(UniProtKB)
IDA
GO:0070062
P07737(UniProtKB)
IDA
GO:0070064
P07737(UniProtKB)
IPI
GO:0071363
P07737(UniProtKB)
IEA
GO:0072562
P07737(UniProtKB)
IDA
GO:1900029
P07737(UniProtKB)
IMP

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控PFN1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
AMYOTROPHIC LATERAL SCLEROSIS 18 0.24 1 4 CLINVAR_UNIPROT
Amyotrophic Lateral Sclerosis 0.124614512 17 1 BeFree_ORPHANET
Keloid 0.12 1 0 CTD_human
Squamous cell carcinoma of esophagus 0.12 1 0 CTD_human
Glomerulonephritis, Membranoproliferative 0.08 1 0 RGD
Mammary Neoplasms 0.002995792 2 0 BeFree_LHGDN
Nasopharyngeal Neoplasms 0.00272435 1 0 LHGDN
Malignant neoplasm of breast 0.002442977 9 0 BeFree
Breast Carcinoma 0.002442977 9 0 BeFree
AMYOTROPHIC LATERAL SCLEROSIS 1 0.001357209 5 0 BeFree
Neoplasm Metastasis 0.001085767 4 0 BeFree
Pick Disease of the Brain 0.001085767 4 1 BeFree
Frontotemporal dementia 0.001085767 4 1 BeFree
Frontotemporal Lobar Degeneration 0.001085767 4 0 BeFree
Renal Cell Carcinoma 0.000814326 3 0 BeFree
Pancreatic carcinoma 0.000814326 3 0 BeFree
Malignant neoplasm of pancreas 0.000814326 3 0 BeFree
Adenocarcinoma 0.000542884 2 0 BeFree
Tumor Progression 0.000542884 2 0 BeFree
Neurodegenerative Disorders 0.000542884 2 0 BeFree
Amyotrophic Lateral Sclerosis, Sporadic 0.000542884 2 0 BeFree
Presenile dementia 0.000271442 1 0 BeFree
Liver neoplasms 0.000271442 1 0 BeFree
Malignant neoplasm of stomach 0.000271442 1 0 BeFree
Spinal Muscular Atrophy 0.000271442 1 0 BeFree
Wiskott-Aldrich Syndrome 0.000271442 1 0 BeFree
Motor Neuron Disease 0.000271442 1 0 BeFree
Carcinoma breast stage IV 0.000271442 1 0 BeFree
Adenocarcinoma of pancreas 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Dementia 0.000271442 1 0 BeFree
Carcinoma of larynx 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Stomach Carcinoma 0.000271442 1 0 BeFree
ABLEPHARON-MACROSTOMIA SYNDROME 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree
Triple Negative Breast Neoplasms 0.000271442 1 0 BeFree
GRN-related frontotemporal dementia 0.000271442 1 0 BeFree

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