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This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  这个基因编码,与外源凝集素分子伴侣钙网蛋白和钙联接蛋白相互作用,以调节新合成的糖蛋白的折叠的内质网的蛋白质。蛋白质曾经被认为是一种磷脂;然而,已经证实,该蛋白实际上具有蛋白二硫键异构酶活性。它被认为是外源凝集素的复合物和该蛋白通过促进它们的糖蛋白底物形成二硫键介导蛋白折叠。 [由RefSeq的,2008年7月提供]
PDIA3基因(以及对应的蛋白质)的细胞分布位置:
PDIA3基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Liver carcinoma | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Prostatic Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Acute Coronary Syndrome | 0.12 | 1 | 0 | CTD_human |
| SPINOCEREBELLAR ATAXIA 17 | 0.12 | 1 | 0 | CTD_human |
| Liver Cirrhosis | 0.080271442 | 2 | 0 | BeFree_RGD |
| Asphyxia Neonatorum | 0.08 | 1 | 0 | RGD |
| Dehydration | 0.08 | 1 | 0 | RGD |
| Pulmonary Hypertension | 0.08 | 1 | 0 | RGD |
| Irritable Bowel Syndrome | 0.08 | 1 | 0 | RGD |
| Myocardial Reperfusion Injury | 0.08 | 1 | 0 | RGD |
| Hepatitis, Autoimmune | 0.08 | 1 | 0 | RGD |
| Stomach Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Male infertility | 0.00272435 | 1 | 0 | LHGDN |
| Malignant neoplasm of prostate | 0.002638474 | 2 | 0 | BeFree_GAD |
| Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.000542884 | 2 | 0 | BeFree |
| Cervix carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
| Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of larynx | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
| Endometriosis | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
| melanoma | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Unipolar Depression | 0.000271442 | 1 | 0 | BeFree |
| Renal fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Recurrent pterygium | 0.000271442 | 1 | 0 | BeFree |
| Prion Diseases | 0.000271442 | 1 | 0 | BeFree |
| Cervical Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| stage, cervical cancer | 0.000271442 | 1 | 0 | BeFree |
| Chronic Kidney Insufficiency | 0.000271442 | 1 | 0 | BeFree |
| Mood Disorders | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of larynx | 0.000271442 | 1 | 0 | BeFree |
| Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
| airway disease | 0.000271442 | 1 | 0 | BeFree |
| Thrombocytosis | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
| Major Depressive Disorder | 0.000271442 | 1 | 0 | BeFree |
| Chronic Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
| Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
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