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This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  这个基因编码的相关构巢曲霉的NIMA(从未有丝分裂基因A)中的丝氨酸/ threionine蛋白激酶家族的一个成员。所编码的蛋白质可从G2在细胞周期进展中的作用为M相。在相关的小鼠基因突变与疾病表型非常类似于人类多囊肾病的少年常染色体隐性形式相关联。 [由RefSeq的,2008年7月提供]
NEK8基因(以及对应的蛋白质)的细胞分布位置:
NEK8基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| NEPHRONOPHTHISIS 9 | 0.24 | 1 | 1 | CLINVAR_UNIPROT |
| Kidney Diseases | 0.12 | 1 | 0 | CTD_human |
| RENAL-HEPATIC-PANCREATIC DYSPLASIA 2 | 0.12 | 0 | 1 | CLINVAR |
| Autosomal Recessive Polycystic Kidney Disease | 0.08 | 0 | 0 | MGD |
| Nephronophthisis | 0.001357209 | 5 | 0 | BeFree |
| Cystic kidney | 0.001085767 | 4 | 0 | BeFree |
| Cystic Kidney Diseases | 0.001085767 | 4 | 0 | BeFree |
| Congenital cystic kidney disease | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
| Hydrocephalus, Normal Pressure | 0.000542884 | 2 | 0 | BeFree |
| Pancreatic carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
| Polycystic Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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