NBL1(neuroblastoma 1, DAN family BMP antagonist) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

1p36.3-p36.2
基因染色体位置图

基因简述

基因简述

This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]

[中文简述(自动翻译):]  这种基因产品是进化上保守的CAN（地狱犬和DAN）家族蛋白，它含有域类似的CTCK（C端胱氨酸结等）在一些信号分子的发现母题的创始成员。这些蛋白质被分泌，并且通过结合到骨形成蛋白，并防止它们与它们的受体相互作用充当BMP（骨形态发生蛋白）拮抗剂。它们可以生长发育过程中从而起到了重要的作用。可变剪接转录物变体已被确定为这个基因。通读（GeneID 440574），该位点与上游线粒体内膜组织系统1基因的转录之间已经观察到。 [由RefSeq的，2013年5月提供]

OMIM数据库中对NBL1基因的介绍     Wikipedia数据库中对NBL1基因的介绍

基因序列

基因序列

NBL1基因的碱基序列：[NCBI]

基因突变

基因突变

NBL1基因的碱基突变：           显示全部snp
rs753612       rs753613       rs1049959       rs1050027       rs1115163       rs1894254       rs2254885       rs2294630       rs2314331       rs2745238       rs2745241       rs2854100       rs2854101       rs2854102       rs2854105       rs2854108       rs3020595       rs3087566       rs3748747       rs3762387       rs3762388       rs3790739       rs3790741       rs3790742       rs3790743       rs3790744       rs3790745       rs3828100       rs3828101       rs3833542       rs4912135       rs6426819       rs6669757       rs6702295       rs7522389       rs7522407       rs7522416      
rs7546665       rs7551544       rs10569237       rs10631531       rs10753570       rs10917507       rs10917508       rs11430584       rs11587840       rs11589378       rs11589390       rs11808455       rs11810271       rs12040294       rs12046364       rs12086418       rs12089208       rs12143032       rs12408663       rs12736790       rs28564005       rs35118801       rs35989027       rs36030380       rs36040394       rs41264093       rs41264095       rs55976853       rs56912210       rs58231562       rs58601674       rs59232326       rs60043590       rs60301848       rs60600249       rs60948101       rs61071252       rs61114955       rs61765157       rs71008199       rs71512950       rs71579812       rs71579813       rs71645456       rs71645457       rs72419091       rs72656078       rs72656079       rs72656086       rs72961714       rs72961716       rs72961720       rs72961731       rs74056943       rs74527909       rs74652341       rs76014377       rs77271599       rs77787313       rs77791778       rs78065427       rs78288976       rs78869581       rs78895165       rs79061523       rs79540600       rs111232153       rs111331264       rs111402009       rs111511364       rs111903141       rs111932135       rs111949284       rs112044925       rs112118255       rs112142723       rs112207580       rs112214724       rs112303475       rs112363848       rs112384235       rs112479984       rs112805738       rs112872860       rs112896382       rs112982388       rs112984228       rs113162075       rs113340482       rs113417255       rs113565150       rs113585754       rs113639275       rs113693320       rs113834819       rs114005845       rs114052989       rs114537358       rs114669249       rs114857251       rs114953974       rs115518777       rs115614639       rs115748095       rs115829688       rs115849191       rs115963039       rs115999325       rs116247768       rs116250449       rs116304476       rs116431883       rs137890123       rs137920907       rs138005780       rs138060702       rs138522416       rs138548140       rs139196947       rs139459537       rs139510360       rs140114169       rs140426006       rs140544840       rs140910882       rs140961737       rs141130080       rs141545984       rs142152951       rs142431554       rs142481240       rs142601488       rs143151300       rs143270944       rs143294488       rs143460920       rs143625024       rs143954563       rs144205506       rs144366484       rs144407941       rs144673479       rs144752855       rs145173852       rs145434189       rs145557056       rs145589139       rs145598890       rs145783966       rs145792674       rs145979227       rs146505927       rs146532449       rs147523987       rs147545185       rs148221802       rs148347719       rs148800383       rs149147572       rs149160377       rs149258105       rs149793933       rs150195265       rs150672442       rs150723530       rs151241899       rs180756074       rs180800545       rs180939046       rs181172691       rs181636152       rs181823870       rs181986223       rs182247253       rs182479213       rs182502169       rs183023887       rs183067758       rs183178340       rs183329609       rs183598746       rs183657795       rs183850650       rs183942930       rs184062970       rs184427249       rs184598127       rs184762853       rs184840429       rs185005011       rs185203446       rs185940040       rs186237538       rs186578866       rs186599165       rs186682356       rs187207590       rs187272421       rs187404869       rs187792325       rs187817660       rs187895122       rs188430696       rs188475661       rs188681333       rs188722922       rs188897316       rs189513582       rs189627985       rs189796544       rs189886164       rs190360783       rs190459695       rs190704998       rs190735476       rs190823805       rs191015959       rs191396402       rs191419888       rs191453207       rs191523472       rs191534769       rs191961593       rs192069871       rs192107904       rs192304668       rs192765046       rs192854260       rs193137902       rs199930955       rs200072488       rs200087124       rs200483320       rs200525019       rs201056089       rs201365345       rs201558270       rs201616380       rs201653889       rs202183847       rs367788510       rs367936061       rs368049579       rs368224136       rs368401173       rs368817501       rs368827659       rs369170734       rs369507602       rs369866044       rs369899885       rs371065967       rs371859192       rs371901214       rs371903407       rs372086277       rs372271081       rs372372469       rs372460291       rs372590199       rs372763348       rs373111147       rs373322514       rs373716922       rs374084909       rs374085720       rs374282010       rs375025222       rs375130730       rs375145976       rs376542517       rs376552112       rs376656347       rs377209511       rs377330810       rs377584402       rs377679649       rs397782630       rs527467787       rs527524427       rs527556917       rs527740659       rs527800439       rs528093345       rs528125919       rs528354236       rs528719789       rs528784207       rs529260960       rs529354018       rs529390871       rs529535662       rs529759492       rs529872391       rs529910841       rs530085436       rs530517160       rs530520910       rs531117777       rs531163910       rs531202543       rs531480574       rs531508163       rs531600284       rs531663542       rs531761062       rs532140819       rs532415759       rs532453038       rs532563346       rs532601834       rs532627116       rs532637554       rs532963625       rs533358775       rs533398510       rs533435348       rs533916479       rs533931561       rs533951915       rs533985303       rs533995290       rs534217383       rs534264904       rs534304673       rs534836507       rs534877367       rs535067794       rs535102868       rs535128036       rs535170481       rs535734381       rs535839822       rs536043701       rs536107521       rs536400021       rs536635988       rs537305493       rs537631145       rs537672127       rs537879309       rs537899037       rs537979274       rs538229217       rs538484238       rs538713986       rs538865618       rs539038204       rs539038673       rs539299237       rs539478196       rs539901318       rs540020287       rs540057030       rs540060837       rs540092579       rs540211957       rs540374009       rs540396919       rs540433536       rs540570936       rs540576630       rs540850207       rs540968159       rs541406106       rs541446673       rs541596538       rs541631806       rs541769534       rs541796376       rs541803573       rs542396414       rs542433201       rs542653529       rs543000457       rs543103269       rs543229066       rs543588199       rs543813474       rs543945043       rs544219302       rs544415437       rs544415473       rs544453274       rs544744040       rs544934320       rs545053608       rs545216480       rs545435945       rs545474491       rs545510315       rs545882096       rs546258589       rs546295292       rs546403014       rs546592129       rs546770044       rs546823377       rs546960352       rs546994885       rs547153114       rs547482510       rs547977667       rs548051235       rs548102832       rs548140953       rs548371403       rs548654339       rs548708702       rs548754435       rs548975232       rs549110958       rs549283946       rs549323158       rs549330282       rs549383781       rs549527988       rs549910984       rs549917969       rs550123674       rs550486883       rs550572240       rs550714795       rs550832312       rs550954899       rs551098689       rs551100607       rs551306555       rs551555324       rs551610627       rs552209183       rs552296252       rs552509856       rs552621026       rs552896981       rs553319655       rs553493536       rs553679569       rs554500887       rs554698497       rs554747206       rs554761646       rs554862645       rs555043458       rs555078819       rs555227629       rs555274164       rs555368059       rs555467039       rs555665154       rs555849762       rs555987636       rs556017184       rs556058618       rs556113441       rs556218494       rs556262925       rs556476903       rs556678731       rs556800454       rs556922424       rs557303526       rs557491512       rs557665526       rs557766573       rs557896820       rs558059225       rs558357600       rs558487108       rs558529900       rs558613282       rs558644005       rs558674999       rs559000198       rs559617108       rs559734662       rs559867685       rs560006489       rs560191240       rs560217634       rs560318598       rs560383676       rs560821793       rs561031132       rs561185014       rs561302169       rs561644197       rs561655286       rs561880775       rs562024271       rs562069029       rs562385650       rs562425020       rs562699478       rs562783224       rs562791082       rs562841453       rs562920305       rs563162958       rs563636026       rs563814372       rs564032324       rs564119898       rs564447678       rs564829079       rs564829384       rs565057560       rs565088845       rs565172110       rs565201588       rs565386579       rs565660068       rs565698446       rs566498738       rs566572714       rs566601860       rs566638370       rs566934843       rs567423778       rs567543812       rs567569124       rs567952713       rs568081272       rs568175693       rs568317596       rs568678433       rs568718368       rs568752535       rs569003417       rs569119168       rs569314855       rs569350995       rs569395102       rs569432471       rs569623459       rs569680126       rs569821428       rs569940206       rs570331566       rs570345949       rs570460196       rs570463273       rs570817625       rs571068790       rs571401664       rs571437992       rs571516753       rs571550884       rs571589047       rs571724155       rs571945298       rs571982024       rs572021035       rs572093366       rs572144246       rs572905251       rs573137570       rs573163840       rs573229974       rs573233681       rs573483195       rs573816332       rs573856405       rs573866057       rs574144415       rs574318212       rs574355802       rs574415719       rs575414973       rs575677450       rs575814344       rs575823900       rs575874944       rs575899864       rs575903486       rs576840509       rs576870136       rs577024104       rs577054470       rs577126028       rs577131443       rs577518338       rs578096941       rs745866345       rs746020093       rs746110765       rs746522320       rs746686819       rs746880468       rs747074342       rs747172237       rs747376473       rs747691945       rs747711299       rs748624953       rs748990782       rs749092380       rs749288127       rs749323652       rs749726493       rs749875570       rs750591766       rs750974701       rs751284678       rs751431326       rs751636272       rs752223440       rs752315145       rs752467940       rs752664341       rs752696086       rs752802378       rs753076569       rs753485771       rs753749134       rs753749974       rs754167547       rs754377247       rs754585959       rs754641009       rs754785157       rs754978370       rs755180124       rs755306139       rs755996613       rs756472856       rs756837366       rs757287257       rs757735439       rs757823454       rs758129048       rs758669412       rs758757270       rs759649214       rs760069960       rs760397890       rs760923430       rs761221368       rs761290655       rs761592651       rs761694876       rs763142069       rs763744695       rs763881820       rs763923820       rs764490791       rs765257995       rs765758691       rs765860187       rs765948448       rs766504658       rs766590259       rs766791857       rs767415373       rs767428488       rs768319754       rs768660778       rs768756805       rs769009180       rs769540977       rs769658008       rs769746888       rs769869045       rs769880816       rs770313889       rs770380450       rs770832411       rs770961935       rs771026603       rs771243421       rs771364944       rs771510556       rs772214809       rs772593662       rs773096865       rs773289675       rs773431028       rs773693467       rs774348089       rs774846005       rs775127851       rs775320456       rs775409340       rs775811354       rs776141684       rs776248573       rs776460594       rs776840933       rs777555673       rs777675093       rs777958738       rs778071969       rs778522323       rs778808881       rs779465735       rs779488898       rs779944158       rs779977622       rs780413916       rs780531015       rs780602241       rs780837203       rs780900032       rs781203048       rs781458245       rs781581627       rs3790742       rs145792674       rs555368059      

基因表达

基因表达

NBL1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TCCATGTGGGAGATTGTGAC
60
CAGGATCTTCTCCACCAGC
60
TCCATGTGGGAGATTGTGAC
60
GCAGGATCTTCTCCACCAG
60
GAACATCACCCAGATCGTG
58
GTAGCTGAAGCACTGTCCT
59
AACATCACCCAGATCGTGG
60
TGTAGCTGAAGCACTGTCC
60
CAAGTCCATCCAGAACAGG
58
CAGTGAACCAGGGACTCTG
60
CTTCCCACAGTCCACAGAG
60
ACTCCAGCGTCACAATCTC
60
TCCATGTGGGAGATTGTGAC
60
CAGGATCTTCTCCACCAGC
60
CTAGGACAGTGCTTCAGCT
59
ACTCCAGCGTCACAATCTC
60
TCCATGTGGGAGATTGTGAC
60
GCAGGATCTTCTCCACCAG
60
TCCATGTGGGAGATTGTGAC
60
CAGGATCTTCTCCACCAGC
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

NBL1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

NBL1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005515
P41271(UniProtKB)
IPI
GO:0005515
P41271(UniProtKB)
IPI
GO:0005515
P41271(UniProtKB)
IPI
GO:0005515
P41271(UniProtKB)
IPI
GO:0005615
P41271(UniProtKB)
IC
GO:0007399
P41271(UniProtKB)
ISS
GO:0016015
P41271(UniProtKB)
ISS
GO:0030514
P41271(UniProtKB)
IDA
GO:0035582
P41271(UniProtKB)
ISS
GO:0036122
P41271(UniProtKB)
ISS
GO:0038098
P41271(UniProtKB)
IDA
GO:0042803
P41271(UniProtKB)
IMP
GO:0045666
P41271(UniProtKB)
ISS
GO:0048263
P41271(UniProtKB)
ISS
GO:0048812
P41271(UniProtKB)
ISS
GO:0090027
P41271(UniProtKB)
ISS

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控NBL1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Neuroblastoma 0.001085767 4 0 BeFree
Central neuroblastoma 0.001085767 4 0 BeFree
Pancreatic carcinoma 0.000814326 3 0 BeFree
Malignant neoplasm of pancreas 0.000542884 2 0 BeFree

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