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This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  这个基因倒在5q13染色体复制一个500 KB的一部分。这种重复区域包含至少四个基因和重复元件,这使得它易于重排和缺失。序列的重复性和复杂性也确定该基因组区域的组织造成的困难。该基因的这个副本全长;以截断和内部缺失额外的副本也存在于5q13染色体的这个区域。据认为,这种基因是在邻近的基因,SMN1突变引起的脊髓性肌萎缩的改性剂。由该基因编码的蛋白质中包含同源的区域,以抑制细胞凋亡蛋白两种杆状病毒,并且还能够抑制细胞凋亡的各种信号诱导。已发现该基因编码不同亚型选择性剪接转录变异体。 [由RefSeq的,2008年7月提供]
NAIP基因(以及对应的蛋白质)的细胞分布位置:
NAIP基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| HMN (Hereditary Motor Neuropathy) Proximal Type I | 0.120814326 | 3 | 0 | BeFree_ORPHANET |
| Juvenile Spinal Muscular Atrophy | 0.12 | 0 | 0 | ORPHANET |
| Muscular Atrophy, Spinal, Type II | 0.12 | 0 | 0 | ORPHANET |
| Brain Ischemia | 0.08 | 1 | 0 | RGD |
| Spinal Muscular Atrophy | 0.033732194 | 68 | 0 | BeFree_GAD_LHGDN |
| Spinal Muscular Atrophies of Childhood | 0.005091382 | 2 | 0 | GAD_LHGDN |
| Fabry Disease | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Muscular Atrophy | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| leukemia | 0.00272435 | 1 | 0 | LHGDN |
| Multiple Sclerosis | 0.00272435 | 1 | 0 | LHGDN |
| Mammary Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Amyotrophic Lateral Sclerosis | 0.001085767 | 4 | 0 | BeFree |
| Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Arthrogryposis | 0.000271442 | 1 | 0 | BeFree |
| Bacterial Infections | 0.000271442 | 1 | 0 | BeFree |
| Atrial Septal Defects | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis, Alcoholic | 0.000271442 | 1 | 0 | BeFree |
| Ischemia | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma, Follicular | 0.000271442 | 1 | 0 | BeFree |
| Impaired cognition | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
| Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Inflammatory disorder | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
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