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DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
[中文简述(自动翻译):]  DNA甲基化是真核基因组的主要修改,并播放在哺乳动物发育中起重要作用。此基因属于核蛋白的家族,其特征是一个甲基-CpG结合结构域(MBD)的存在。所编码的蛋白质是NURD,含有核小体重构和组蛋白脱乙酰活动多亚基复合物的亚基。不像其他家庭成员,所编码的蛋白质是不能够结合甲基化DNA。蛋白质介导转移相关蛋白2与核心组蛋白脱乙酰复杂的关联。选择性剪接的结果在该基因的多个转录物变体。 [由RefSeq的,2013年7月提供]
MBD3基因(以及对应的蛋白质)的细胞分布位置:
MBD3基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Autistic Disorder | 0.12 | 1 | 0 | CTD_human |
| Transient Ischemic Attack | 0.08 | 1 | 0 | RGD |
| Seizures | 0.08 | 1 | 0 | RGD |
| Acute Promyelocytic Leukemia | 0.00272435 | 1 | 0 | LHGDN |
| Malignant neoplasm of lung | 0.000814326 | 3 | 0 | BeFree |
| Carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Gastritis | 0.000271442 | 1 | 0 | BeFree |
| Lupus Erythematosus, Subacute Cutaneous | 0.000271442 | 1 | 0 | BeFree |
| Pemphigus Vulgaris | 0.000271442 | 1 | 0 | BeFree |
| Vitiligo | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | 0.000271442 | 1 | 0 | BeFree |
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