LTB基因详情-基因数据库-基因云馆

LTB(lymphotoxin beta (TNF superfamily, member 3)) 转至新版数据库

基因简称(symbol)

LTB [HGNC] [GeneCards] [NCBI]

基因种类(locus group)

protein-coding gene

同源简称(alias symbol)

p33|TNFSF3

基因家族代码(gene_family_id)

781 [HGNC] [GenScript]

omim代码

600978

entrez码

4050 [Vega]

vega基因码

OTTHUMG00000031136

ensembl基因码

ENSG00000227507 [Ensembl]

基因家族(gene family)

Tumor necrosis factor (ligand) superfamily

refseq数据库代号

NM_002341

更多...

基因种类(locus_type)

gene with protein product

基因名称状态(status)

Approved

location_sortable

06p21.3

同源基因名称(alias name)

基因名称批准使用时间(date_approved_reserved)

1995-11-22T00:00:00Z

基因简称更名时间(date_symbol_changed)

基因名称更名时间(date_name_changed)

更新时间(date_modified)

2014-11-18T00:00:00Z

ucsc码

uc003nuk.3

ena

L11015

ccds数据码

CCDS4703|CCDS4704

uniprot数据码

Q06643

pubmed代码

7916655|1714477

mgd码

MGI:104796

rgd码

RGD:1303162

生命科学数据库(lsdb)

更新时间(date modified)

2014-11-18T00:00:00Z

cosmic

LTB

mirbase

基因曾用简称(prev symbol)

TNFC

基因曾用名称(prev name)

homeodb

cosmic

LTB

snornabase

bioparadigms slc

orphanet

假基因信息(pseudogeneorg)

horde id

merops

imgt

iuphar

kznf基因类别

mamit-trnadb

cd

LncRNA数据库

酶代码

中间纤维数据库

收起

6p21.3

Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):] 淋巴毒素测试是TNF家族的II型膜蛋白。它通过异源三聚形成锚淋巴毒素-α向细胞表面上。淋巴细胞表面上的主要形式是淋巴-α1 / Beta 2的复合物（例如1分子的α/ 2分子测试版），这是复杂的淋巴毒素β受体的主要配体。次要复杂的是淋巴毒素α - 2 /测试1. LTB是炎症反应系统的诱导和参与淋巴组织的正常发展。淋巴毒素-β同种型b为不能与淋巴毒素-α暗示为淋巴毒素-β的函数是独立lympyhotoxin-α的复合物。在多个转录剪接变异体导致编码不同亚型。 [由RefSeq的，2008年7月提供]

OMIM数据库中对LTB基因的介绍 Wikipedia数据库中对LTB基因的介绍

LTB基因的碱基序列：[NCBI]

LTB基因的碱基突变：显示全部snp

rs116646885 rs185171624 rs199696143 rs533381190 rs536057655 rs540049272 rs544723785 rs574049707 rs769174 rs769175 rs2022045 rs2229698 rs2229699 rs3093549 rs3093550 rs3093551 rs3093552 rs3093553 rs3093554 rs3093555 rs3093556 rs3093557 rs3093562 rs3093563 rs4248165 rs4645846 rs4647173 rs4647174 rs4647175 rs4647176 rs4647177 rs4647178 rs4647179 rs4647180 rs4647181 rs4647182 rs4647183

rs4647185 rs4647186 rs4647187 rs4647188 rs7766988 rs11574937 rs28993446 rs61761329 rs72847273 rs111928720 rs112508585 rs112978613 rs113048856 rs115773593 rs116012195 rs137958291 rs138010841 rs138680740 rs139528542 rs140734819 rs140984421 rs143260958 rs145227210 rs145800710 rs146263569 rs146590429 rs147118182 rs147687880 rs148698319 rs148973682 rs149139835 rs149833445 rs181617527 rs182320786 rs183262541 rs183510030 rs184485821 rs185251429 rs186288832 rs188898001 rs189710917 rs189982676 rs191194850 rs191324201 rs192441465 rs192699700 rs192935963 rs200589720 rs201767749 rs367597516 rs368062974 rs369223933 rs370654316 rs371205199 rs371392111 rs371717567 rs373114079 rs373924525 rs374715643 rs375282274 rs375959608 rs376604338 rs527252991 rs527383173 rs527721339 rs527986770 rs528241609 rs528561107 rs529088558 rs530635529 rs530682179 rs531161090 rs531885432 rs532177689 rs532552573 rs532757438 rs533313224 rs533565882 rs534349570 rs534416162 rs534717676 rs535107236 rs535812294 rs536122305 rs536474367 rs536720537 rs536733696 rs537190570 rs537728367 rs538180237 rs538795548 rs538858213 rs539140775 rs539329812 rs539375712 rs539650569 rs540038900 rs540186001 rs541039297 rs541177858 rs541235925 rs541371875 rs541787102 rs542279471 rs543043879 rs543181955 rs543196679 rs543486002 rs543725873 rs543806412 rs544081396 rs544256611 rs545155588 rs545502086 rs545532207 rs545602578 rs546580317 rs547739890 rs548359966 rs549662357 rs549725707 rs549758820 rs549778866 rs550114281 rs550621149 rs550691999 rs550826374 rs551098549 rs551211007 rs551494547 rs552024407 rs552223075 rs552426688 rs552983134 rs553120309 rs553202953 rs553997400 rs554258732 rs555062699 rs555196393 rs555259726 rs556082388 rs556454123 rs556679693 rs556812665 rs557178688 rs557400970 rs557525918 rs558384302 rs558646836 rs558709918 rs558908557 rs558947212 rs559500401 rs559690698 rs560484795 rs560512361 rs560780179 rs561522036 rs561526636 rs561587978 rs561802689 rs562950629 rs562961152 rs563458164 rs563979837 rs564236919 rs564851224 rs565323051 rs565596357 rs565846321 rs565926974 rs566098575 rs566235016 rs567175785 rs567302751 rs567843528 rs568071028 rs568160727 rs568424902 rs569397869 rs569462305 rs569798966 rs570146198 rs570480191 rs570615074 rs571318566 rs571521242 rs571847945 rs572443884 rs572578191 rs572733705 rs572807966 rs573476205 rs573864094 rs574347851 rs574383971 rs574727222 rs575140707 rs575439940 rs575774556 rs576076186 rs576316691 rs576331800 rs576419715 rs576862768 rs577005429 rs577795781 rs745342101 rs745496226 rs745632598 rs745861894 rs746032169 rs746154946 rs746474704 rs746783589 rs746871696 rs746890037 rs747146913 rs747747033 rs747802092 rs748277200 rs748549211 rs748760498 rs748778397 rs748892009 rs749006755 rs749356097 rs749364985 rs749537484 rs749649327 rs749707085 rs749816841 rs750491976 rs750545997 rs750720058 rs750985995 rs751117037 rs751402678 rs751489672 rs751622453 rs751889844 rs751997573 rs752118549 rs752120570 rs752287469 rs752344375 rs752684862 rs753030483 rs753714925 rs753879029 rs754031108 rs754199753 rs754493378 rs754534730 rs754586202 rs755175031 rs755539032 rs755798731 rs756014417 rs756030008 rs756320691 rs756484322 rs756494348 rs757044134 rs757175031 rs757398909 rs757614993 rs757889756 rs758126945 rs758551748 rs758559042 rs758603951 rs758699441 rs759278792 rs759356743 rs759586959 rs759857394 rs759969846 rs760487691 rs760535967 rs761208149 rs761297790 rs761424698 rs761615561 rs761793331 rs761813329 rs762064139 rs762268761 rs762518936 rs763229141 rs763579832 rs763660526 rs763751199 rs764191828 rs764564215 rs764607003 rs764758435 rs764915610 rs764980924 rs765133451 rs765370402 rs765766320 rs765945616 rs766109943 rs766346248 rs766714578 rs766804237 rs766850960 rs767079533 rs767445083 rs767458880 rs767488608 rs767612196 rs767882226 rs767989636 rs768097986 rs768265451 rs768328850 rs768498333 rs768674004 rs768712112 rs768807517 rs769131084 rs769538375 rs769689253 rs769694557 rs770076727 rs770228387 rs770282624 rs770457212 rs770693455 rs771169298 rs771177108 rs771306687 rs771510355 rs771741120 rs772102869 rs772262931 rs772436170 rs772617554 rs773073256 rs773170624 rs773275519 rs773330649 rs773644231 rs773699696 rs773826252 rs773880151 rs773988157 rs774039337 rs774206101 rs774369588 rs774553384 rs774898008 rs775163349 rs775174983 rs775344697 rs776020976 rs776586567 rs776753743 rs776818298 rs776875834 rs777247583 rs777281236 rs777955797 rs777963449 rs778324461 rs778494063 rs778583395 rs778691458 rs779091722 rs779144669 rs779144854 rs779325903 rs779459157 rs779671727 rs779677170 rs779722936 rs779840486 rs779842279 rs779860052 rs780178658 rs780308657 rs780982679 rs781235062 rs781264928 rs781543258 rs781720215

LTB基因在不同组织中的表达： [UniProt]

正向引物序列

正向引物Tm值

反向引物序列

反向引物Tm值

rank

CAGAAACAGATCTCAGCCC

57

GGTAATAGAGGCCGTCCTG

59

GAGGACTGGTAACGGAGAC

59

AGATCTGTTTCTGGCTCCTC

59

CCAGAAACAGATCTCAGCC

57

GGTAATAGAGGCCGTCCTG

59

GAGGACTGGTAACGGAGAC

59

ATCTGTTTCTGGCTCCTCC

59

CAGAAACAGATCTCAGCCC

57

AGGTAATAGAGGCCGTCCT

59

GAGGACTGGTAACGGAGAC

59

GAGATCTGTTTCTGGCTCCT

59

尚未收录相关数据

LTB基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

溶酶体
内涵体
细胞核
细胞质
液泡
细胞膜
细胞外基质
内质网
线粒体
高尔基体
细胞骨架

LTB基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0005102

Q06643(UniProtKB)

TAS

GO:0005125

Q06643(UniProtKB)

IEA

GO:0005164

Q06643(UniProtKB)

IEA

GO:0005575

Q06643(UniProtKB)

ND

GO:0005615

Q06643(UniProtKB)

IEA

GO:0005886

Q06643(UniProtKB)

TAS

GO:0005886

Q06643(UniProtKB)

TAS

GO:0005886

Q06643(UniProtKB)

TAS

GO:0005886

Q06643(UniProtKB)

TAS

GO:0005886

Q06643(UniProtKB)

TAS

GO:0006955

Q06643(UniProtKB)

IEA

GO:0007165

Q06643(UniProtKB)

TAS

GO:0007267

Q06643(UniProtKB)

TAS

GO:0010467

Q06643(UniProtKB)

IEA

GO:0016021

Q06643(UniProtKB)

IEA

GO:0033209

Q06643(UniProtKB)

TAS

GO:0033209

Q06643(UniProtKB)

TAS

GO:0043588

Q06643(UniProtKB)

IEA

GO:0045084

Q06643(UniProtKB)

ISS

GO:0048535

Q06643(UniProtKB)

IEA

序号	作用方式	资源库来源/分值	基因名称	基因名称

可能调控LTB基因的相关microRNA：

hsa-miR-122 hsa-miR-148b hsa-miR-146a

通路基因列表

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Rheumatoid Arthritis	0.005634266	3	0	BeFree_GAD_LHGDN
Asthma	0.003452799	4	0	BeFree_GAD
Atherosclerosis	0.002638474	2	0	BeFree_GAD
Malaria	0.002638474	2	0	BeFree_GAD
Myocardial Infarction	0.002638474	2	0	BeFree_GAD
Intracranial Arteriosclerosis	0.002367032	1	0	GAD
Brain Ischemia	0.002367032	1	0	GAD
Lupus Erythematosus, Systemic	0.002367032	1	0	GAD
Malaria, Falciparum	0.002367032	1	0	GAD
Cerebrovascular accident	0.002367032	1	0	GAD
Vasculitis	0.002367032	1	0	GAD
Coronary Artery Disease	0.002367032	1	0	GAD
Malignant neoplasm of breast	0.000542884	2	0	BeFree
Crohn Disease	0.000542884	2	0	BeFree
Myeloid Leukemia, Chronic	0.000542884	2	0	BeFree
Lymphoma	0.000542884	2	0	BeFree
Malignant neoplasm of pancreas	0.000542884	2	0	BeFree
Breast Carcinoma	0.000542884	2	0	BeFree
Arthritis	0.000271442	1	0	BeFree
Bronchitis, Chronic	0.000271442	1	0	BeFree
Shigella Infections	0.000271442	1	0	BeFree
HIV Infections	0.000271442	1	0	BeFree
Hodgkin Disease	0.000271442	1	0	BeFree
Huntington Disease	0.000271442	1	0	BeFree
Inflammatory Bowel Diseases	0.000271442	1	0	BeFree
leukemia	0.000271442	1	0	BeFree
Chronic Lymphocytic Leukemia	0.000271442	1	0	BeFree
Acute lymphocytic leukemia	0.000271442	1	0	BeFree
Leukemia, Myelocytic, Acute	0.000271442	1	0	BeFree
Liver neoplasms	0.000271442	1	0	BeFree
Chronic Obstructive Airway Disease	0.000271442	1	0	BeFree
Peritonitis	0.000271442	1	0	BeFree
Pneumonia	0.000271442	1	0	BeFree
Pulmonary Emphysema	0.000271442	1	0	BeFree
Tuberculosis	0.000271442	1	0	BeFree
Tumor Progression	0.000271442	1	0	BeFree
Pancreatic carcinoma	0.000271442	1	0	BeFree
Oedema auricular	0.000271442	1	0	BeFree
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	0.000271442	1	0	BeFree
Sleep Apnea, Obstructive	0.000271442	1	0	BeFree
Leukemogenesis	0.000271442	1	0	BeFree
airway disease	0.000271442	1	0	BeFree
Small Lymphocytic Lymphoma	0.000271442	1	0	BeFree
Chronic graft-versus-host disease	0.000271442	1	0	BeFree
Liver regeneration disorder	0.000271442	1	0	BeFree
Leprosy, Multibacillary	0.000271442	1	0	BeFree
Precursor Cell Lymphoblastic Leukemia Lymphoma	0.000271442	1	0	BeFree
Liver carcinoma	0.000271442	1	0	BeFree